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This paper is placed at the intersection-point between the study of theoretical computational models aimed at capturing the essence of genetic regulatory networks and the field of Artificial Embryology (or Computational Development). A…

Adaptation and Self-Organizing Systems · Physics 2016-10-12 Alessandro Fontana

Experimental results in recent years have shown that adult neurogenesis is a significant phenomenon in the mammalian brain. Little is known, however, about the functional role played by the generation and destruction of neurons in the…

Neurons and Cognition · Quantitative Biology 2009-11-10 Guillermo A. Cecchi , Marcelo O. Magnasco

Preterm birth disrupts the typical trajectory of cortical neurodevelopment, increasing the risk of cognitive and behavioral difficulties. However, outcomes vary widely, posing a significant challenge for early prediction. To address this,…

Neurons and Cognition · Quantitative Biology 2025-09-19 Zhenshan Xie , Levente Baljer , M. Jorge Cardoso , Emma Robinson

This work simulates the developmental process of cortical neurogenesis, initiating from a single stem cell and governed by gene regulatory rules derived from mouse single-cell transcriptomic data. The developmental process spontaneously…

Neural and Evolutionary Computing · Computer Science 2026-04-17 Duan Zhou

Neuronal circuits arise as axons and dendrites extend, navigate, and connect to target cells. Axonal growth, in particular, integrates deterministic guidance from substrate mechanics and geometry with stochastic fluctuations generated by…

Biological Physics · Physics 2025-10-10 Cristian Staii

Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally and functionally diverse, they accomplish a central role in determining the delays and reliability with which neuronal ensembles communicate. By…

Neurons and Cognition · Quantitative Biology 2019-05-07 Pepe Alcami , Ahmed El Hady

Neuromorphic engineering is essentially the development of artificial systems, such as electronic analog circuits that employ information representations found in biological nervous systems. Despite being faster and more accurate than the…

Neural and Evolutionary Computing · Computer Science 2022-09-07 Arvind Subramaniam

This paper considers neural representation through the lens of active inference, a normative framework for understanding brain function. It delves into how living organisms employ generative models to minimize the discrepancy between…

Neurons and Cognition · Quantitative Biology 2023-10-24 Giovanni Pezzulo , Leo D'Amato , Francesco Mannella , Matteo Priorelli , Toon Van de Maele , Ivilin Peev Stoianov , Karl Friston

We introduce NeuralOS, a neural framework that simulates graphical user interfaces (GUIs) of operating systems by directly predicting screen frames in response to user inputs such as mouse movements, clicks, and keyboard events. NeuralOS…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Luke Rivard , Sun Sun , Hongyu Guo , Wenhu Chen , Yuntian Deng

Big science initiatives are trying to reconstruct and model the brain by attempting to simulate brain tissue at larger scales and with increasingly more biological detail than previously thought possible. The exponential growth of parallel…

Performance · Computer Science 2020-06-25 Francesco Cremonesi , Georg Hager , Gerhard Wellein , Felix Schürmann

Although Deep Neural Networks have seen great success in recent years through various changes in overall architectures and optimization strategies, their fundamental underlying design remains largely unchanged. Computational neuroscience on…

Machine Learning · Computer Science 2019-12-17 Paul Bertens , Seong-Whan Lee

Artificial neural networks and computational neuroscience models have made tremendous progress, allowing computers to achieve impressive results in artificial intelligence (AI) applications, such as image recognition, natural language…

Neural and Evolutionary Computing · Computer Science 2019-11-05 Giacomo Indiveri , Yulia Sandamirskaya

Artificial Intelligence has looked into biological systems as a source of inspiration. Although there are many aspects of the brain yet to be discovered, neuroscience has found evidence that the connections between neurons continuously grow…

Neural and Evolutionary Computing · Computer Science 2020-10-29 Javier Lopez Randulfe , Leon Bonde Larsen

Deciphering the underpinnings of the dynamical processes leading to information transmission, processing, and storing in the brain is a crucial challenge in neuroscience. An inspiring but speculative theoretical idea is that such dynamics…

Statistical Mechanics · Physics 2023-07-21 Guillermo B. Morales , Serena Di Santo , Miguel A. Muñoz

Biological nervous systems consist of networks of diverse, sophisticated information processors in the form of neurons of different classes. In most artificial neural networks (ANNs), neural computation is abstracted to an activation…

Neural and Evolutionary Computing · Computer Science 2023-06-12 Joachim Winther Pedersen , Sebastian Risi

Over the past decade there has been a growing interest in the development of parallel hardware systems for simulating large-scale networks of spiking neurons. Compared to other highly-parallel systems, GPU-accelerated solutions have the…

Neurons and Cognition · Quantitative Biology 2021-02-22 Bruno Golosio , Gianmarco Tiddia , Chiara De Luca , Elena Pastorelli , Francesco Simula , Pier Stanislao Paolucci

Living neural networks emerge through a process of growth and self-organization that begins with a single cell and results in a brain, an organized and functional computational device. Artificial neural networks, however, rely on…

Neural and Evolutionary Computing · Computer Science 2019-06-05 Guruprasad Raghavan , Matt Thomson

This paper deals with the cellular biological network analysis of the tumor-growth model, consisting of multiple spaces and time scales. In this paper, we present a model in graph simulation using ABM for tumor growth. In particular, we…

Multiagent Systems · Computer Science 2019-09-05 Ghazal Tashakor , Remo Suppi

Denoising diffusion models represent a recent emerging topic in computer vision, demonstrating remarkable results in the area of generative modeling. A diffusion model is a deep generative model that is based on two stages, a forward…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Florinel-Alin Croitoru , Vlad Hondru , Radu Tudor Ionescu , Mubarak Shah

Computational modeling is becoming a widely used methodology in modern neuroscience. However, as the complexity of the phenomena under study increases, the analysis of the results emerging from the simulations concomitantly becomes more…

Neurons and Cognition · Quantitative Biology 2020-03-16 Sergio E. Galindo , Pablo Toharia , Oscar D. Robles , Eduardo Ros , Luis Pastor , Jesús A. Garrido