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We investigate the global dynamics of a renewal-type epidemic model with variable susceptibility. We show that in this extended model there exists a unique endemic equilibrium and prove that it is globally asymptotically stable when $R_0 >…

Dynamical Systems · Mathematics 2020-07-24 Michael T. Meehan , Daniel G. Cocks , Emma S. McBryde

Dengue and Zika incidence data and the latest research have raised questions about how dengue vaccine strategies might be impacted by the emergence of Zika virus. Existing antibodies to one virus might temporarily protect or promote…

Populations and Evolution · Quantitative Biology 2023-03-14 Lorena C. Bulhosa , Juliane F. Oliveira

Multi-strain competition on networks is observed in many contexts, including infectious disease ecology, information dissemination or behavioral adaptation to epidemics. Despite a substantial body of research has been developed considering…

Evolution has fascinated quantitative and physical scientists for decades: how can the random process of mutation, recombination, and duplication of genetic information generate the diversity of life? What determines the rate of evolution?…

Populations and Evolution · Quantitative Biology 2018-04-23 Richard A. Neher , Aleksandra M. Walczak

We study a diffusive SIS epidemic model with the mass-action transmission mechanism and show, under appropriate assumptions on the parameters, the existence of multiple endemic equilibria (EE). Our results answer some open questions on…

Analysis of PDEs · Mathematics 2023-11-07 Keoni Castellano , Rachidi B. Salako

The shape of an epidemic wave in simple epidemic models applies to a homogeneous distribution of infected people in the population. In large inhomogeneous systems, at country-scale for instance, the wave shape is similar except for the…

Chemical Physics · Physics 2022-11-21 L. Vanel

We study the impact of contact heterogeneity on epidemic dynamics. A system characterized by multiple susceptible populations is considered. The description of the spread of an infectious disease is obtained through the study of a system of…

Physics and Society · Physics 2021-11-11 Andrea Medaglia , Mattia Zanella

Among various possible causes of autoimmune disease, an important role is played by infections that can result in a breakdown of immune tolerance, primarily through the mechanism of "molecular mimicry". In this paper we propose and analyse…

Tissues and Organs · Quantitative Biology 2018-05-21 F. Fatehi , S. N. Kyrychko , A. Ross , Y. N. Kyrychko , K. B. Blyuss

A single-column model run under the weak temperature gradient approximation, a parameterization of large-scale dynamics appropriate for the tropical atmosphere, is shown to have multiple stable equilibria. Under conditions permitting…

Atmospheric and Oceanic Physics · Physics 2015-05-13 Adam H. Sobel , Gilles Bellon , Julio T. Bacmeister

Understanding and modelling the complexity of the immune system is a challenge that is shared by the ImmunoComplexiT$^1$ thematic network from the RNSC. The immune system is a complex biological, adaptive, highly diversified, self-organized…

Quantitative Methods · Quantitative Biology 2020-08-27 Véronique Thomas-Vaslin

The persistence of biodiversity of species is a challenging proposition in ecological communities in the face of Darwinian selection. The present article investigates beyond the pairwise competitive interactions and provides a novel…

Populations and Evolution · Quantitative Biology 2022-11-09 Sourin Chatterjee , Sayantan Nag Chowdhury , Dibakar Ghosh , Chittaranjan Hens

System dynamics and agent based simulation models can both be used to model and understand interactions of entities within a population. Our modeling work presented here is concerned with understanding the suitability of the different types…

Computational Engineering, Finance, and Science · Computer Science 2013-06-27 Grazziela P. Figueredo , Uwe Aickelin

Disease awareness in infection dynamics can be modeled with adaptive contact networks whose rewiring rules reflect the attempt by susceptibles to avoid infectious contacts. Simulations of this type of models show an active phase with…

Adaptation and Self-Organizing Systems · Physics 2012-12-06 Stefan Wieland , Tomas Aquino , Ana Nunes

Understanding the interplay of different traits in a co-infection system with multiple strains has many applications in ecology and epidemiology. Because of high dimensionality and complex feedbacks between traits manifested in infection…

Dynamical Systems · Mathematics 2021-04-16 Thi Minh Thao Le , Erida Gjini , Sten Madec

We extend a recent investigation by Meehan et al. (2019) regarding the global stability properties of the general Kermack-McKendrick (renewal) model to the multi-strain case. We demonstrate that the basic reproduction number of each strain…

Populations and Evolution · Quantitative Biology 2019-07-03 Michael T. Meehan , Daniel G. Cocks , Emma S. McBryde

We consider an aggregation model for two interacting species. The coupling between the species is via their velocities, that incorporate self- and cross-interactions. Our main interest is categorizing the possible steady states of the…

Analysis of PDEs · Mathematics 2016-12-26 Joep H. M. Evers , Razvan C. Fetecau , Theodore Kolokolnikov

A compartment epidemic model for infectious disease spreading is investigated, where movement of individuals is governed by spatial diffusion. The model includes infection age of the infected individuals and assumes a logistic growth of the…

Analysis of PDEs · Mathematics 2023-06-28 Christoph Walker

This article is concerned with the long time behavior of neutral genetic population models, with fixed population size. We design an explicit, finite, exact, genealogical tree based representation of stationary populations that holds both…

Probability · Mathematics 2007-05-23 Pierre Del Moral , Laurent Miclo , Frédéric Patras , Sylvain Rubenthaler

There has been interest in the interactions between infectious disease dynamics and behaviour for most of the history of mathematical epidemiology. This has included consideration of which mathematical models best capture each phenomenon,…

Populations and Evolution · Quantitative Biology 2025-12-09 Matthew Ryan , Roslyn I. Hickson , Edward M. Hill , Thomas House , Valerie Isham , Dongni Zhang , Mick G. Roberts

In this paper, we study the number of equilibria of the replicator-mutator dynamics for both deterministic and random multi-player two-strategy evolutionary games. For deterministic games, using Decartes' rule of signs, we provide a formula…

Dynamical Systems · Mathematics 2019-10-14 Manh Hong Duong , The Anh Han
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