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Biological diversity has evolved despite the essentially infinite complexity of protein sequence space. We present a hierarchical approach to the efficient searching of this space and quantify the evolutionary potential of our approach with…

Statistical Mechanics · Physics 2009-10-31 Leonard D. Bogarad , Michael W. Deem

The formation of a collectively moving group benefits individuals within a population in a variety of ways such as ultra-sensitivity to perturbation, collective modes of feeding, and protection from environmental stress. While some…

Biological Physics · Physics 2014-10-28 Shashi Thutupalli , Mingzhai Sun , Filiz Bunyak , Kannappan Palaniappan , Joshua. W. Shaevitz

The problem of organizing data that evolves over time into clusters is encountered in a number of practical settings. We introduce evolutionary subspace clustering, a method whose objective is to cluster a collection of evolving data points…

Computer Vision and Pattern Recognition · Computer Science 2019-01-30 Abolfazl Hashemi , Haris Vikalo

The observed properties of young star clusters, such as the core radius and luminosity profile, change rapidly during the early evolution of the clusters. Here we present observations of 6 young clusters in M51 where we derive their sizes…

Astrophysics · Physics 2009-11-13 N. Bastian , M. Gieles , S. P. Goodwin , G. Trancho , L. J. Smith , I. Konstantopoulos , Yu. Efremov

We study gravitational clustering of mass points in three dimensions with random initial positions and periodic boundary conditions (no expansion) by numerical simulations. Correlation properties are well defined in the system and a sort of…

Statistical Mechanics · Physics 2009-11-07 M. Bottaccio , A. Amici , P. Miocchi , R. Capuzzo Dolcetta , M. Montuori , L. Pietronero

The conceptual landscape of convection has two simple gateways: optimal function and random form. Optimal convection adjusts toward a univariate ideal called neutrality. Convection form involves elements (parcels, bubbles, drafts) whose…

Adaptation and Self-Organizing Systems · Physics 2025-04-02 Brian E. Mapes

Cellular nutrient consumption is influenced by both the nutrient uptake kinetics of an individual cell and the cells' spatial arrangement. Large cell clusters or colonies have inhibited growth at the cluster's center due to the shielding of…

Biological Physics · Physics 2013-06-14 Maxim O. Lavrentovich , John H. Koschwanez , David R. Nelson

Recent models and simulations of cluster formation within molecular clumps consider multi-scale, hierarchical accretion, which leads to clump mass growth over time. This mode of mass accumulation could have implications regarding the…

Astrophysics of Galaxies · Physics 2026-03-11 Nicholas Larose , C. R. Kerton , Kathryn Devine , Grace Wolf-Chase

Context. Galaxy evolution and the effect of environment are most often studied using scaling relations or some regression analyses around some given property. These approaches however do not take into account the complexity of the physics…

Astrophysics of Galaxies · Physics 2019-09-25 Didier Fraix-Burnet , Mauro d'Onofrio , Paola Marziani

Biologists have long observed periodic-like oxygen consumption oscillations in yeast populations under certain conditions and several unsatisfactory explanations for this phenomenon have been proposed. These "autonomous oscillations" have…

Dynamical Systems · Mathematics 2011-12-02 Erik M. Boczko , Tomas Gedeon , Chris C. Stowers , Todd Young

Despite the greater functional importance of protein levels, our knowledge of gene expression evolution is based almost entirely on studies of mRNA levels. In contrast, our understanding of how translational regulation evolves has lagged…

Genomics · Quantitative Biology 2013-12-02 Carlo G. Artieri , Hunter B. Fraser

The sequence of a protein is not only constrained by its physical and biochemical properties under current selection, but also by features of its past evolutionary history. Understanding the extent and the form that these evolutionary…

Populations and Evolution · Quantitative Biology 2015-06-22 Mathieu Hemery , Olivier Rivoire

At what level does selective pressure effectively act? When considering the reproductive dynamics of interacting and mutating agents, it has long been debated whether selection is better understood by focusing on the individual or if…

Populations and Evolution · Quantitative Biology 2023-11-02 Hardik Rajpal , Clem von Stengel , Pedro A. M. Mediano , Fernando E. Rosas , Eduardo Viegas , Pablo A. Marquet , Henrik J. Jensen

We study the clustering of a model cyanobacterium \textit{Synechocystis} into microcolonies. The bacteria are allowed to diffuse onto surfaces of different hardness, and interact with the others by aggregation and detachment. We find that…

Biological Physics · Physics 2020-03-04 Thomas Vourc'h , Julien Léopoldès , Hassan Peerhossaini

Cooperation is ubiquitous in nature, but explaining its existence remains a central interdisciplinary challenge. Cooperation is most difficult to explain in the Prisoner's Dilemma game, where cooperators always lose in direct competition…

Populations and Evolution · Quantitative Biology 2013-11-13 J. David Van Dyken , Melanie J. I. Muller , Keenan M. L. Mack , Michael M. Desai

The budding yeast {\it Saccharomyces cerevisiae} is the first eukaryote whose genome has been completely sequenced. It is also the first eukaryotic cell whose proteome (the set of all proteins) and interactome (the network of all mutual…

Disordered Systems and Neural Networks · Physics 2009-11-10 A. R. Mashaghi , A. Ramezanpour , V. Karimipour

The evolutionary success of bacteria lies in their ability to form complex surface-associated communities in diverse biophysical settings. However, it remains poorly understood how compliance of soft surfaces, measured in terms of their…

Soft Condensed Matter · Physics 2025-08-05 Garima Rani , Anupam Sengupta

Many examples of cooperation exist in biology. In chemical systems however, which can sometimes be quite complex, we do not appear to observe intricate cooperative interactions. A key question for the origin of life, is then how can…

Populations and Evolution · Quantitative Biology 2018-02-23 Omer Markovitch , Olaf Witkowski , Nathaniel Virgo

Gene regulatory dynamics is governed by molecular processes and therefore exhibits an inherent stochasticity. However, for the survival of an organism it is a strict necessity that this intrinsic noise does not prevent robust functioning of…

Molecular Networks · Quantitative Biology 2007-05-23 Stefan Braunewell , Stefan Bornholdt

The problem of unicellular-multicellular transition is one of the main issues that is discussing in evolutionary biology. In [1] the fitness of a colony of cells is considered in terms of its two basic components, viability and fecundity.…

Populations and Evolution · Quantitative Biology 2015-06-08 Fuad Aleskerov , Denis Tverskoy