Related papers: Capillary Network, Cancer and Kleiber Law
We present in silico simulations and mathematical analyses supporting several hypotheses that explain the saturation expressed in the fractional cell kill law that governs the lysis of tumor cells by cytotoxic CD8 + T cells (CTLs). In order…
For a substance diffusing on a curved surface, we obtain an explicit relation valid for very small values of the time, between the local concentration, the diffusion coefficient, the intrinsic spatial curvature and the time. We recover the…
A macroscopic model of the tumor Gompertzian growth is proposed. The new approach is based on the energetic balance among the different cell activities, described by methods of statistical mechanics and related to the growth inhibitor…
We study pattern-forming dissipative systems in growing domains. We characterize classes of boundary conditions that allow for defect-free growth and derive universal scaling laws for the wavenumber in the bulk of the domain. Scalings are…
We derive diffusive macroscopic equations for the particle and energy density of a system whose time evolution is described by a kinetic equation for the one particle position and velocity function f(r,v,t) that consists of a part that…
We propose a new model for the emergence of blood capillary networks. We assimilate the tissue and extra cellular matrix as a porous medium, using Darcy's law for describing both blood and intersticial fluid flows. Oxygen obeys a…
In this paper we present a study of local dynamics of the growth of cancer tumor and healthy cells considering the presence of nutrients in the system. We also analyze the evolution of system if we take indirectly into account the level of…
We study the diffusion equation with a position-dependent, power-law diffusion coefficient. The equation possesses the Riesz-Weyl fractional operator and includes a memory kernel. It is solved in the diffusion limit of small wave numbers.…
In this paper we study and extend the mechanistic mean field theory of growth of cellular populations proposed by Mombach et al in (Mombach J. C. M. et al., Europhysics Letter, 59 (2002) 923) (MLBI model), and we demonstrate that the…
Initiation and development of a malignant tumor is a complex phenomenon that has critical stages determining its long time behavior. This phenomenon is mathematically described by means of various models: from simple heuristic models to…
In this paper, a distributed optimal control problem is studied for a diffuse interface model of tumor growth which was proposed in [A. Hawkins-Daruud, K.G. van der Zee, J.T. Oden, Numerical simulation of a thermodynamically consistent…
Cancer is viewed as a multistep process whereby a normal cell is transformed into a cancer cell through the acquisition of mutations. We reduce the complexities of cancer progression to a simple set of underlying rules that govern the…
We consider a mathematical model for the evolutionary dynamics of tumour cells in vascularised tumours under chemotherapy. The model comprises a system of coupled partial integro-differential equations for the phenotypic distribution of…
We consider a (degenerate) cross-diffusion model of tumor growth structured by phenotypic trait. We prove the existence of weak solutions and the incompressible limit as the pressure becomes stiff extending methods recently introduced in…
A two-dimensional free boundary model for the growth of multi-layer tumors has been proposed in [S. Cui, J. Escher: ARMA 191 (2009) 173-193] where the authors derive well-posedness in a functional analytic setting, the stationary solutions…
We consider a (1+1)-dimensional ballistic deposition process with next-nearest neighbor interaction, which belongs to the KPZ universality class, and introduce for this discrete model a variational formulation similar to that for the…
We analyze a phase field model for tumor growth consisting of a Cahn-Hilliard-Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The…
We study the spatial evolutionary dynamics of solid tumors as they obtain additional driver mutations. We start with a cancer clone that expands uniformly in three dimensions giving rise to a spherical shape. We assume that cell division…
Cancer progression and monotonic accumulation models were developed to discover dependencies in the irreversible acquisition of binary traits from cross-sectional data. They have been used in computational oncology and virology but also in…
We investigate the evolution of tumor growth relying on a nonlinear model of partial differential equations which incorporates mechanical laws for tissue compression combined with rules for nutrients availability and drug application.…