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Optimal Bayesian design techniques provide an estimate for the best parameters of an experiment in order to maximize the value of measurements prior to the actual collection of data. In other words, these techniques explore the space of…

Computational Physics · Physics 2020-08-11 Alexander Tarakanov , Ahmed H. Elsheikh

Many chemical and biological experiments involve multiple treatment factors and often it is convenient to fit a nonlinear model in these factors. This nonlinear model can be mechanistic, empirical or a hybrid of the two. Motivated by…

Computation · Statistics 2018-10-09 Yuanzhi Huang , Steven Gilmour , Kalliopi Mylona , Peter Goos

In discrete choice experiments, the information matrix depends on the model parameters. Therefore designing optimally informative experiments for arbitrary initial parameters often yields highly nonlinear optimization problems and makes…

Statistics Theory · Mathematics 2025-07-18 Frank Röttger , Thomas Kahle , Rainer Schwabe

Efficient algorithms for convex optimization, such as the ellipsoid method, require an a priori bound on the radius of a ball around the origin guaranteed to contain an optimal solution if one exists. For linear and convex quadratic…

Data Structures and Algorithms · Computer Science 2025-11-06 Lucas Slot , David Steurer , Manuel Wiedmer

We propose a computational approach to constructing exact designs on finite design spaces that are optimal for multiresponse regression experiments under a combination of the standard linear and specific 'sparsity' constraints. The linear…

Methodology · Statistics 2026-02-13 Lenka Filová , Pál Somogyi , Radoslav Harman

We present an exactly solvable random-subcube model inspired by the structure of hard constraint satisfaction and optimization problems. Our model reproduces the structure of the solution space of the random k-satisfiability and k-coloring…

Computational Complexity · Computer Science 2008-05-23 Thierry Mora , Lenka Zdeborova

In multi-response regression models, the error covariance matrix is never known in practice. Thus, there is a need for optimal designs which are robust against possible misspecification of the error covariance matrix. In this paper, we…

Methodology · Statistics 2019-10-03 Lucy L. Gao , Julie Zhou

Let $G$ be a finite subgroup of $\mbox{GL}(2)$ acting on $\mathbf{A}^2\setminus\{0\}$ freely. The $G$-orbit Hilbert scheme $G\mbox{-Hilb}(\mathbf{A}^2)$ is a minimal resolution of the quotient $\mathbf{A}^2/G$. We determine the generator…

Algebraic Geometry · Mathematics 2016-09-15 Akira Ishii , Iku Nakamura

Physical design refers to mathematical optimization of a desired objective (e.g. strong light--matter interactions, or complete quantum state transfer) subject to the governing dynamical equations, such as Maxwell's or Schrodinger's…

Optics · Physics 2023-04-03 Shai Gertler , Zeyu Kuang , Colin Christie , Owen D. Miller

Complete reliance on the fitted model in response surface experiments is risky and relaxing this assumption, whether out of necessity or intentionally, requires an experimenter to account for multiple conflicting objectives. This work…

Methodology · Statistics 2023-06-16 Olga Egorova , Steven G. Gilmour

The purpose of this short note is to show that the Christoffel-Darboux polynomial, useful in approximation theory and data science, arises naturally when deriving the dual to the problem of semi-algebraic D-optimal experimental design in…

Optimization and Control · Mathematics 2020-12-09 Yohann de Castro , Fabrice Gamboa , Didier Henrion , Jean Lasserre

We consider optimal experimental design (OED) for Bayesian inverse problems, where the experimental design variables have a certain multiway structure. Given $d$ different experimental variables with $m_i$ choices per design variable $1 \le…

Numerical Analysis · Mathematics 2025-06-03 Hugo Díaz , Arvind K. Saibaba , Srinivas Eswar , Vishwas Rao , Zichao Wendy Di

We typically construct optimal designs based on a single objective function. To better capture the breadth of an experiment's goals, we could instead construct a multiple objective optimal design based on multiple objective functions. While…

Methodology · Statistics 2023-03-09 Lucy L. Gao , Jane J. Ye , Shangzhi Zeng , Julie Zhou

In this paper optimal designs for regression problems with spherical predictors of arbitrary dimension are considered. Our work is motivated by applications in material sciences, where crystallographic textures such as the missorientation…

Statistics Theory · Mathematics 2017-10-31 Holger Dette , Maria Konstantinou , Kirsten Schorning , Josua Gösmann

We develop and analyse a first-order algorithm for the A-optimal experimental design problem. The problem is first presented as a special case of a parametric family of optimal design problems for which duality results and optimality…

Computation · Statistics 2013-11-12 Selin Damla Ahipasaoglu

We consider the problem of designing experiments for the comparison of two regression curves describing the relation between a predictor and a response in two groups, where the data between and within the group may be dependent. In order to…

Statistics Theory · Mathematics 2021-01-15 Kirsten Schorning , Holger Dette

In the one-parameter regression model with AR(1) and AR(2) errors we find explicit expressions and a continuous approximation of the optimal discrete design for the signed least square estimator. The results are used to derive the optimal…

Statistics Theory · Mathematics 2016-02-12 Holger Dette , Andrey Pepelyshev , Anatoly Zhigljavsky

We address the problem of the best uniform approximation by linear combinations of a finite system of functions. If the system is Chebyshev and the problem is unconstrained, then the classical Remez algorithm provides a fast and precise…

Numerical Analysis · Mathematics 2025-07-08 Vladimir Yu. Protasov , Rinat Kamalov

We present a random-subspace variant of cubic regularization algorithm that chooses the size of the subspace adaptively, based on the rank of the projected second derivative matrix. Iteratively, our variant only requires access to…

Optimization and Control · Mathematics 2025-01-09 Edward Tansley , Coralia Cartis

We construct $\varepsilon$-approximate unitary $k$-designs on $n$ qubits in circuit depth $O(\log k \log \log n k / \varepsilon)$. The depth is exponentially improved over all known results in all three parameters $n$, $k$, $\varepsilon$.…

Quantum Physics · Physics 2025-07-22 Laura Cui , Thomas Schuster , Fernando Brandao , Hsin-Yuan Huang
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