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Clustering is a common technique for statistical data analysis, Clustering is the process of grouping the data into classes or clusters so that objects within a cluster have high similarity in comparison to one another, but are very…

Machine Learning · Computer Science 2012-03-12 T Soni Madhulatha

Region-based methods have proven necessary for improving segmentation accuracy of neuronal structures in electron microscopy (EM) images. Most region-based segmentation methods use a scoring function to determine region merging. Such…

Computer Vision and Pattern Recognition · Computer Science 2018-04-04 Ting Liu , Miaomiao Zhang , Mehran Javanmardi , Nisha Ramesh , Tolga Tasdizen

We present a geometry-aware method for heterogeneous single-particle cryogenic electron microscopy (cryo-EM) reconstruction that predicts atomic backbone conformations. To incorporate protein-structure priors, we represent the backbone as a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Jonathan Krook , Axel Janson , Joakim Andén , Melanie Weber , Ozan Öktem

In single particle reconstruction (SPR) from cryo-electron microscopy (cryo-EM), the 3D structure of a molecule needs to be determined from its 2D projection images taken at unknown viewing directions. Zvi Kam showed already in 1980 that…

Computer Vision and Pattern Recognition · Computer Science 2016-02-24 Tejal Bhamre , Teng Zhang , Amit Singer

X-ray as well as electron diffraction are powerful tools for structure determination of molecules. Studies on randomly oriented molecules in the gas-phase address cases in which molecular crystals cannot be generated or the interaction-free…

Cryo-electron microscopy (cryo-EM) is a powerful imaging technique for reconstructing three-dimensional molecular structures from noisy tomographic projection images of randomly oriented particles. We introduce a new data fusion framework,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-15 Joe Kileel , Oscar Mickelin , Amit Singer , Sheng Xu

While the contents of Euclid's Elements are well-known these days, some characters of the original text have been overlooked due to interpretation by modern mathematical languages. The lens of modern mathematics once anachronistically…

History and Overview · Mathematics 2025-06-16 Byungchang So

In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Jiakai Zhang , Qihe Chen , Yan Zeng , Wenyuan Gao , Xuming He , Zhijie Liu , Jingyi Yu

Motivation: Structural heterogeneity in single-particle cryo-electron microscopy (cryo-EM) data represents a major challenge for high-resolution structure determination. Unsupervised classification may serve as the first step in the…

Data Analysis, Statistics and Probability · Physics 2017-11-01 Jiayi Wu , Yong-Bei Ma , Charles Congdon , Bevin Brett , Shuobing Chen , Qi Ouyang , Youdong Mao

Some key notions of line geometry are recalled, along with their application to mechanics. It is then shown that most of the basic structures that one introduces in the pre-metric formulation of electromagnetism can be interpreted directly…

General Relativity and Quantum Cosmology · Physics 2013-09-13 D. H. Delphenich

Diagram semigroups are interesting algebraic and combinatorial objects, several types of them originating from questions in computer science and in physics. Here we describe diagram semigroups in a general framework and extend our…

Group Theory · Mathematics 2015-02-27 James East , Attila Egri-Nagy , Andrew R. Francis , James D. Mitchell

We construct a class of microscopic electron models with exact SO(5) symmetry between antiferromagnetic and d-wave superconducting ground states. There is an exact one-to-one correspondence between both single-particle and collective…

Superconductivity · Physics 2009-01-23 Silvio Rabello , Hiroshi Kohno , Eugene Demler , Shou-Cheng Zhang

Atomic-resolution imaging with scanning transmission electron microscopy is a powerful tool for characterizing the nanoscale structure of materials, in particular features such as defects, local strains, and symmetry-breaking distortions.…

Cryo-Electron Microscopy (cryo-EM) has become an extremely powerful method for resolving structural details of large biomolecular complexes. However, challenging problems in single-particle methods remain open because of (1) the low…

Biomolecules · Quantitative Biology 2019-08-12 Shengnan Lyu , Christian Wülker , Yuqing Pan , Amitesh S. Jayaraman , Jianhao Zheng , Yilin Cai , Gregory S. Chirikjian

Scanning Electron Microscopy (SEM) is indispensable in modern materials science, enabling high-resolution imaging across a wide range of structural, chemical, and functional investigations. However, SEM imaging remains constrained by…

After the discovery of GMR by Fert and Gr\"unberg, electronics had a breakthrough with the birth of a new branch called spintronics. This discipline, while still young, exploits the spin of electrons. Most quantum devices exploiting this…

Mesoscale and Nanoscale Physics · Physics 2015-01-27 Yann Claveau

Modern nanomaterials contain complexity that spans all three dimensions - from multigate semiconductors to clean energy nanocatalysts to complex block copolymers. For nanoscale characterization, it has been a long-standing goal to observe…

Applied Physics · Physics 2020-06-03 Robert Hovden , David A. Muller

Four-dimensional scanning transmission electron microscopy (4D-STEM) provides rich, atomic-scale insights into materials structures. However, extracting specific physical properties - such as polarization directions essential for…

Predicting interactions between small molecules and proteins is a crucial ingredient of the drug discovery process. In particular, accurate predictive models are increasingly used to preselect potential lead compounds from large molecule…

Quantitative Methods · Quantitative Biology 2007-09-26 Laurent Jacob , Jean-Philippe Vert

Cryo-electron microscopy (cryo-EM) is an indispensable technique for determining the 3D structures of dynamic biomolecular complexes. While typically applied to image a single molecular species, cryo-EM has the potential for structure…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Jeffrey Gu , Minkyu Jeon , Ambri Ma , Serena Yeung-Levy , Ellen D. Zhong