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Automated classification methods for disease diagnosis are currently in the limelight, especially for imaging data. Classification does not fully meet a clinician's needs, however: in order to combine the results of multiple tests and…

Quantitative Methods · Quantitative Biology 2018-05-07 PierGianLuca Porta Mana , Claudia Bachmann , Abigail Morrison

Firth-type logistic regression has become a standard approach for the analysis of binary outcomes with small samples. Whereas it reduces the bias in maximum likelihood estimates of coefficients, bias towards 1/2 is introduced in the…

Methodology · Statistics 2021-01-20 Rainer Puhr , Georg Heinze , Mariana Nold , Lara Lusa , Angelika Geroldinger

Recently Hui et al. (2018) use F tests for testing a subset of random effect, demonstrating its computational simplicity and exactness when the first two moment of the random effects are specified. We extended the investigation of the F…

Methodology · Statistics 2018-12-11 P. Y. O'Shaughnessy , Francis Hui , Samuel Muller , A. H. Welsh

The design of optimal test statistics is a key task in frequentist statistics and for a number of scenarios optimal test statistics such as the profile-likelihood ratio are known. By turning this argument around we can find the profile…

Methodology · Statistics 2022-03-25 Lukas Heinrich

Dispersion is a fundamental concept in statistics, yet standard approaches - especially via stochastic orders - face limitations in the discrete setting. In particular, the classical dispersive order, well-established for continuous…

Methodology · Statistics 2025-11-11 Andreas Eberl , Bernhard Klar , Alfonso Suárez-Llorens

Traditionally, the Dirichlet-multinomial distribution has been recognized as a key model for contingency tables generated by cluster sampling schemes. There are, however, other possible distributions appropriate for these contingency…

Methodology · Statistics 2016-09-26 Juana M. Alonso-Revenga , Nirian Martin , Leandro Pardo

This work is motivated by learning the individualized minimal clinically important difference, a vital concept to assess clinical importance in various biomedical studies. We formulate the scientific question into a high-dimensional…

Methodology · Statistics 2023-03-28 Huijie Feng , Jingyi Duan , Yang Ning , Jiwei Zhao

This paper introduces a test for fractional integration in a model that possibly contains smooth deterministic trends. We model the trend component using a Chebyshev polynomial and specify the short-run dynamics semi-parametrically,…

Econometrics · Economics 2026-03-27 Mustafa R. Kılınç , Michael Massmann

The quality of consequences in a decision making problem under (severe) uncertainty must often be compared among different targets (goals, objectives) simultaneously. In addition, the evaluations of a consequence's performance under the…

Artificial Intelligence · Computer Science 2022-12-15 Christoph Jansen , Georg Schollmeyer , Thomas Augustin

Alignments provide sophisticated diagnostics that pinpoint deviations in a trace with respect to a process model and their severity. However, approaches based on trace alignments use crisp process models as reference and recent…

Databases · Computer Science 2021-07-09 Giacomo Bergami , Fabrizio Maria Maggi , Marco Montali , Rafael Peñaloza

Calibration is a vital aspect of the performance of risk prediction models, but research in the context of ordinal outcomes is scarce. This study compared calibration measures for risk models predicting a discrete ordinal outcome, and…

Statistical matching methods are widely used in the social and health sciences to estimate causal effects using observational data. Often the objective is to find comparable groups with similar covariate distributions in a dataset, with the…

Applications · Statistics 2021-01-19 Felix Bestehorn , Maike Bestehorn , Christian Kirches

This paper reviews and compares methods to assess treatment effect heterogeneity in the context of parametric regression models. These methods include the standard likelihood ratio tests, bootstrap likelihood ratio tests, and Goeman's…

Applications · Statistics 2026-02-06 Yao Chen , Sophie Sun , Konstantinos Sechidis , Cong Zhang , Torsten Hothorn , Björn Bornkamp

Industrial control applications require detecting system anomalies as accurately and quickly as possible to enable prompt maintenance. In this context, it is common to consider several possible plant models, each linked to a different…

Systems and Control · Electrical Eng. & Systems 2026-04-14 Alejandro Penacho Riveiros , Matthieu Barreau , Nicola Bastianello

The effects of an aperiodic order or a random disorder on phase transitions in statistical mechanics are discussed. A heuristic relevance criterion based on scaling arguments as well as specific results for Ising models with random disorder…

Statistical Mechanics · Physics 2007-05-23 Uwe Grimm

One fundamental statistical question for research areas such as precision medicine and health disparity is about discovering effect modification of treatment or exposure by observed covariates. We propose a semiparametric framework for…

Methodology · Statistics 2020-08-04 Muxuan Liang , Menggang Yu

In this paper we discuss how to evaluate the differences between fitted logistic regression models across sub-populations. Our motivating example is in studying computerized diagnosis for learning disabilities, where sub-populations based…

Methodology · Statistics 2023-03-24 Guy Ashiri-Prossner , Yuval Benjamini

Simulation-based inference methods that feature correct conditional coverage of confidence sets based on observations that have been compressed to a scalar test statistic require accurate modeling of either the p-value function or the…

Machine Learning · Statistics 2025-08-18 Ali Al Kadhim , Harrison B. Prosper

Probabilistic models are often trained by maximum likelihood, which corresponds to minimizing a specific f-divergence between the model and data distribution. In light of recent successes in training Generative Adversarial Networks,…

Machine Learning · Statistics 2024-12-17 Mingtian Zhang , Thomas Bird , Raza Habib , Tianlin Xu , David Barber

Experiments often yield non-identically distributed data for statistical analysis. Tests of hypothesis under such set-ups are generally performed using the likelihood ratio test, which is non-robust with respect to outliers and model…

Statistics Theory · Mathematics 2017-07-25 Abhik Ghosh , Ayanendranath Basu