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Following Fisher, it is widely believed that randomization "relieves the experimenter from the anxiety of considering innumerable causes by which the data may be disturbed." In particular, it is said to control for known and unknown…

Methodology · Statistics 2017-10-02 Uwe Saint-Mont

Meta-analysis is an important tool for combining results from multiple studies and has been widely used in evidence-based medicine for several decades. This paper reports, for the first time, an interesting and valuable paradox in…

Applications · Statistics 2019-05-15 Jiandong Shi , Aimin Wu , Tiejun Tong

In experimental and observational data settings, researchers often have limited knowledge of the reasons for missing outcomes. To address this uncertainty, we propose bounds on causal effects for missing outcomes, accommodating the scenario…

Methodology · Statistics 2026-03-19 Max Rubinstein , Denis Agniel , Larry Han , Marcela Horvitz-Lennon , Sharon-Lise Normand

The Jeffreys-Lindley paradox stands as the most profound divergence between frequentist and Bayesian approaches to hypothesis testing. Yet despite more than six decades of discussion, this paradox remains frequently misunderstood--even in…

Statistics Theory · Mathematics 2025-12-01 Miodrag M. Lovric

Statistical insignificance does not suggest the absence of effect, yet scientists must often use null results as evidence of negligible (near-zero) effect size to falsify scientific hypotheses. Doing so must assess a result's null strength,…

This paper considers how to classify the effects of interventions in causal models for outcomes and exposures observed over time. First, we demonstrate the limitations of the most common uses of potential outcomes and causal directed…

Methodology · Statistics 2026-05-29 Russell Steele , Naftali Weinberger , Tess Baker , Ian Shrier

Understanding causal mechanisms across different populations is essential for designing effective public health interventions. Recently, difference graphs have been introduced as a tool to visually represent causal variations between two…

Artificial Intelligence · Computer Science 2025-02-18 Charles K. Assaad

This paper concerns the probabilistic evaluation of the effects of actions in the presence of unmeasured variables. We show that the identification of causal effect between a singleton variable X and a set of variables Y can be accomplished…

Artificial Intelligence · Computer Science 2013-02-21 David Galles , Judea Pearl

Retrospective causal questions ask what would have happened to an observed individual had they received a different treatment. We study the problem of estimating $\mu(x,y)=\mathbb{E}[Y(1)\mid X=x,Y(0)=y]$, the expected counterfactual…

Methodology · Statistics 2026-03-31 Juraj Bodik

The primary objective of this paper is to revisit Simpson's paradox using a statistical misspecification perspective. It is argued that the reversal of statistical associations is sometimes spurious, stemming from invalid probabilistic…

Methodology · Statistics 2016-05-16 Aris Spanos

Observational studies are the primary source of data for causal inference, but it is challenging when existing unmeasured confounding. Missing data problems are also common in observational studies. How to obtain the causal effects from the…

Methodology · Statistics 2023-05-15 Renzhong Zheng

This paper discusses the fundamental principles of causal inference - the area of statistics that estimates the effect of specific occurrences, treatments, interventions, and exposures on a given outcome from experimental and observational…

Methodology · Statistics 2021-12-03 Francesca Dominici , Falco J. Bargagli-Stoffi , Fabrizia Mealli

We describe and contrast two distinct problem areas for statistical causality: studying the likely effects of an intervention ("effects of causes"), and studying whether there is a causal link between the observed exposure and outcome in an…

Statistics Theory · Mathematics 2021-04-02 A. Philip Dawid , Monica Musio

A century ago, Neyman showed how to evaluate the efficacy of treatment using a randomized experiment under a minimal set of assumptions. This classical repeated sampling framework serves as a basis of routine experimental analyses conducted…

Methodology · Statistics 2024-04-29 Michael Lingzhi Li , Kosuke Imai

For obtaining causal inferences that are objective, and therefore have the best chance of revealing scientific truths, carefully designed and executed randomized experiments are generally considered to be the gold standard. Observational…

Applications · Statistics 2008-11-12 Donald B. Rubin

A central aim of physics education research is to understand the processes of learning and use that understanding to inform instruction. To this end, researchers often conduct studies to measure the effect of classroom interventions on…

Physics Education · Physics 2018-10-25 Luke D. Conlin , Eric Kuo , Nicole R. Hallinen

Statistics has made tremendous advances since the times of Fisher, Neyman, Jeffreys, and others, but the fundamental and practically relevant questions about probability and inference that puzzled our founding fathers remain unanswered. To…

Statistics Theory · Mathematics 2019-09-25 Ryan Martin

The moments of random variables are fundamental statistical measures for characterizing the shape of a probability distribution, encompassing metrics such as mean, variance, skewness, and kurtosis. Additionally, the product moments,…

Methodology · Statistics 2025-05-09 Yuta Kawakami , Jin Tian

We propose a new test to address the nonparametric Behrens-Fisher problem involving different distribution functions in the two samples. Our procedure tests the null hypothesis $\mathcal{H}_0: \theta = \frac{1}{2}$, where $\theta = P(X<Y) +…

Methodology · Statistics 2025-04-09 Stephen Schüürhuis , Frank Konietschke , Edgar Brunner

A popular framework for false discovery control is the random effects model in which the null hypotheses are assumed to be independent. This paper generalizes the random effects model to a conditional dependence model which allows…

Statistics Theory · Mathematics 2008-12-18 Wei Biao Wu