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We present a stochastic computational model to study the mechanism of signalling between a source and a target ionic transporter, both localized on the plasma membrane (PM) and in intracellular nanometre-scale subplasmalemmal signalling…
We have developed a quantitative model for the creation of cytoplasmic Ca2+ gradients near the inner surface of the plasma membrane (PM). In particular we simulated the refilling of the sarcoplasmic reticulum (SR) via PM-SR junctions during…
Accurate regulation of calcium release is essential for cellular signaling, with the spatial distribution of ryanodine receptors (RyRs) playing a critical role. In this study, we present a nonlinear spatial network model that simulates RyR…
A new paradigm has recently emerged in brain science whereby communications between glial cells and neuron-glia interactions should be considered together with neurons and their networks to understand higher brain functions. In particular,…
The strong coupling of plasmonic resonance modes in conductive pyramidal nanoparticles leads to an increase in the density of free charges on the surface. By ensuring plasmonic coupling in the pyramidal nanoparticle lattice, the achieved…
Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signalling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ from ryanodine receptors (RyRs) for cellular contraction,…
Two-dimensional transition metal dichalcogenides (TMDCs), as promising alternative plasmonics supporting materials to graphene, exhibit potential applications in sensing. Here, we propose an ultrasensitive, accurate long-range surface…
Phase separation of saturated micellar network, as a result of cross-linking of branched micelles is established in mixed solutions of the anionic surfactant sodium laurylethersulfate (SLES) and the zwitterionic cocamidopropyl betaine…
Plasmonic surface lattice resonance (SLR) is a phenomenon in which individual localized surface plasmon resonances (LSPRs) excited in periodically-arranged plasmonic nanoparticles couple through the interaction with propagating diffracted…
It is shown, by means of numerical simulations, that intercellular spiral waves of calcium can be initiated in a network of coupled cells as a result of a de-synchronization between Ca2+ oscillations in two domains. No artificial…
CT and MRI are the two most widely used imaging modalities in healthcare, each with its own merits and drawbacks. Combining these techniques in one machine could provide unprecedented resolution and sensitivity in a single scan, and serve…
Projection neurons in the dorsal horn relay nociceptive input to supraspinal centers. During central sensitization, a subset of them switches from tonic firing to plateau potentials with sustained afterdischarges, a change that requires…
Calcium (Ca2+) signalling is one of the most important mechanisms of information propagation in the body. In embryogenesis the interplay between Ca2+ signalling and mechanical forces is critical to the healthy development of an embryo but…
It is demonstrated that velocity selective optical pumping/saturation resonances of reduced absorption in a Rb vapor nanocell with thickness \textit{L=} $\lambda $, 2$\lambda $, and 3$\lambda $ (resonant wavelength $\lambda $ = 780 nm)…
We develop a spatially explicit biophysical model of the hippocampal CA3-CA1 presynaptic bouton to study local calcium dynamics leading to vesicle fusion. A kinetic model with two calcium sensors is formulated specifically for the CA3-CA1…
The influence of calcium channel distribution and geometry of the thalamocortical cell upon its tonic firing and the low threshold spike (LTS) generation was studied in a 3-compartment model, which represents soma, proximal and distal…
The calcium (Ca$^{2+}$) signalling system is important for many cellular processes within the human body. Signals are transmitted within the cell by releasing Ca$^{2+}$ from the endoplasmic reticulum (ER) into the cytosol via clusters of…
Serotonergic neurons of the dorsal raphe nuclei, with their extensive innervation of nearly the whole brain have important modulatory effects on many cognitive and physiological processes. They play important roles in clinical depression…
Understanding the interaction of kilojoule, picosecond laser pulse with long-scale length preplasma or homogeneous near critical density (NCD) plasma is crucial for guiding experiments at national short-pulse laser facilities. Using full…
We demonstrate that tunneling spectra in deeply underdoped Bi$_{2}$Sr$_{2}$CuO$_{6+\delta}$ (Bi2201) and Ca$_2$CuO$_2$Cl$_2$ (CCOC) provide clear evidence for nanoscale phase separation (NPS), causing the gap to fill with doping rather than…