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Large volume of Genomics data is produced on daily basis due to the advancement in sequencing technology. This data is of no value if it is not properly analysed. Different kinds of analytics are required to extract useful information from…

Other Quantitative Biology · Quantitative Biology 2017-07-25 M. Usman Ali , Shahzad Ahmed , Javed Ferzund , Atif Mehmood , Abbas Rehman

Test-time adaptation (TTA) aims to improve model generalizability when test data diverges from training distribution, offering the distinct advantage of not requiring access to training data and processes, especially valuable in the context…

Machine Learning · Computer Science 2024-02-28 Yige Yuan , Bingbing Xu , Liang Hou , Fei Sun , Huawei Shen , Xueqi Cheng

As sequencing technologies become more affordable and genomic databases expand continuously, the reuse of publicly available sequencing data emerges as a powerful strategy for studying microbial pathogens. Indeed, raw sequencing reads…

Quantitative Methods · Quantitative Biology 2025-05-16 Damien Richard , Nils Poulicard

Principal stratification (PS) is a commonly used approach for understanding the mechanisms through which a treatment affects an outcome. The goal of this work is to extend the PS framework to studies with continuous treatments, which…

Methodology · Statistics 2025-05-20 Joseph Antonelli , Minxuan Wu , Fabrizia Mealli , Brenden Beck , Alessandra Mattei

There is growing interest in using the close connection between differential geometry and statistics to model smooth manifold-valued data. In particular, much work has been done recently to generalize principal component analysis (PCA), the…

Other Statistics · Statistics 2016-10-07 Drew Lazar , Lizhen Lin

Identifying patient subgroups with different treatment responses is an important task to inform medical recommendations, guidelines, and the design of future clinical trials. Existing approaches for treatment effect estimation primarily…

Methodology · Statistics 2025-12-10 Vincent Jeanselme , Chang Ho Yoon , Fabian Falck , Brian Tom , Jessica Barrett

Routinely collected clinical blood tests are an emerging molecular data source for large-scale biomedical research but inherently feature irregular sampling and informative observation. Traditional approaches rely on imputation, which can…

Quantitative Methods · Quantitative Biology 2025-03-20 Andrea Zerio , Maya Bechler-Speicher , Tine Jess , Aleksejs Sazonovs

The difference-in-differences (DID) method identifies the average treatment effects on the treated (ATT) under mainly the so-called parallel trends (PT) assumption. The most common and widely used approach to justify the PT assumption is…

Econometrics · Economics 2023-08-23 Kyunghoon Ban , Désiré Kédagni

The sensitivity of ongoing searches for gravitational wave (GW) sources in the ultra-low frequency regime ($10^{-9}$ Hz to $10^{-7}$ Hz) using Pulsar Timing Arrays (PTAs) will continue to increase in the future as more well-timed pulsars…

Instrumentation and Methods for Astrophysics · Physics 2022-07-22 Yi-Qian Qian , Soumya D. Mohanty , Yan Wang

Speech-based Parkinson's disease (PD) detection has gained attention for its automated, cost-effective, and non-intrusive nature. As research studies usually rely on data from diagnostic-oriented speech tasks, this work explores the…

Audio and Speech Processing · Electrical Eng. & Systems 2025-08-29 Terry Yi Zhong , Esther Janse , Cristian Tejedor-Garcia , Louis ten Bosch , Martha Larson

Principal Component Analysis (PCA) is a dimensionality reduction technique widely used to reduce the computational cost associated with numerical simulations of combustion phenomena. However, PCA, which transforms the thermo-chemical state…

Test-time adaptation (TTA) is the problem of updating a pre-trained source model at inference time given test input(s) from a different target domain. Most existing TTA approaches assume the setting in which the target domain is stationary,…

Machine Learning · Computer Science 2023-04-05 Dhanajit Brahma , Piyush Rai

Topological data analysis (TDA) is a versatile tool that can be used to extract scientific knowledge from complex pattern formation processes. However, the physics correspondence between the features obtained from TDA and pattern dynamics…

Pattern Formation and Solitons · Physics 2024-07-09 Yoh-ichi Mototake , Masaichiro Mizumaki , Kazue Kudo , Kenji Fukumizu

ChatGPT is an advanced natural language processing tool with growing applications across various disciplines in medical research. Thematic analysis, a qualitative research method to identify and interpret patterns in data, is one…

Computation and Language · Computer Science 2025-05-08 V Vien Lee , Stephanie C. C. van der Lubbe , Lay Hoon Goh , Jose M. Valderas

Traditional machine learning methods face two main challenges in dealing with healthcare predictive analytics tasks. First, the high-dimensional nature of healthcare data needs labor-intensive and time-consuming processes to select an…

Machine Learning · Computer Science 2022-09-16 Mohammad Amin Morid , Olivia R. Liu Sheng , Joseph Dunbar

Predicting clinical outcome is remarkably important but challenging. Research efforts have been paid on seeking significant biomarkers associated with the therapy response or/and patient survival. However, these biomarkers are generally…

Machine Learning · Computer Science 2020-10-09 Jiancheng Yang , Jiajun Chen , Kaiming Kuang , Tiancheng Lin , Junjun He , Bingbing Ni

Recently popularized randomized methods for principal component analysis (PCA) efficiently and reliably produce nearly optimal accuracy --- even on parallel processors --- unlike the classical (deterministic) alternatives. We adapt one of…

Computation · Statistics 2011-12-23 Nathan Halko , Per-Gunnar Martinsson , Yoel Shkolnisky , Mark Tygert

Timed automata are the formal model for real-time systems. Extensions with discrete probabilistic branching have been considered in the literature and successfully applied. Probabilistic timed automata (PTA) do require all branching…

Logic in Computer Science · Computer Science 2024-03-05 Darion Haase , Joost-Pieter Katoen

We employ the recently introduced Geometric Phase Propagator Approach (GPPA) [Phys. Rev. A85, 062110 (2012)] to develop an improved perturbative scheme for the calculation of life times in driven quantum systems. This incorporates a…

Quantum Physics · Physics 2018-07-06 G. E. Pavlou , A. I. Karanikas , F. K. Diakonos

With the advance of modern technology, more and more data are being recorded continuously during a time interval or intermittently at several discrete time points. They are both examples of "functional data", which have become a prevailing…

Methodology · Statistics 2015-07-21 Jane-Ling Wang , Jeng-Min Chiou , Hans-Georg Mueller