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Until recently, transcriptomics was limited to bulk RNA sequencing, obscuring the underlying expression patterns of individual cells in favor of a global average. Thanks to technological advances, we can now profile gene expression across…

Quantitative Methods · Quantitative Biology 2018-11-30 Miriam Shiffman , William T. Stephenson , Geoffrey Schiebinger , Jonathan Huggins , Trevor Campbell , Aviv Regev , Tamara Broderick

The interplay of biological, social, structural and random factors makes disease forecasting extraordinarily complex. The course of an epidemic exhibits average growth dynamics determined by features of the pathogen and the population, yet…

Populations and Evolution · Quantitative Biology 2022-02-24 Andrea J. Allen , Mariah C. Boudreau , Nicholas J. Roberts , Antoine Allard , Laurent Hébert-Dufresne

The analysis of contagion-diffusion processes in metapopulations is a powerful theoretical tool to study how mobility influences the spread of communicable diseases. Nevertheless, many metapopulation approaches use indistinguishable agents…

Physics and Society · Physics 2022-04-20 Pablo Valgañón , David Soriano-Paños , Alex Arenas , Jesús Gómez-Gardeñes

Understanding age-group dynamics of infectious diseases is a fundamental issue for both scientific study and policymaking. Age-structure epidemic models were developed in order to study and improve our understanding of these dynamics. By…

Populations and Evolution · Quantitative Biology 2019-11-22 Rami Yaari , Amit Huppert , Itai Dattner

Because of its relevance to everyday life, the spreading of viral infections has been of central interest in a variety of scientific communities involved in fighting, preventing and theoretically interpreting epidemic processes. Recent…

The epidemic threshold of a social system is the ratio of infection and recovery rate above which a disease spreading in it becomes an epidemic. In the absence of pharmaceutical interventions (i.e. vaccines), the only way to control a given…

In the present work the spread of epidemic is studied over complex networks which are characterized by power law degree distribution of links and heterogeneous rate of disease transmission. The random allocation of epidemic transmission…

Physics and Society · Physics 2016-07-19 Vikram Sagar , Yi Zhao

We propose an epidemic model for the spread of vector-borne diseases. The model, which is built extending the classical susceptible-infected-susceptible model, accounts for two populations -- humans and vectors -- and for cross-contagion…

Systems and Control · Electrical Eng. & Systems 2025-10-21 Lorenzo Zino , Alessandro Casu , Alessandro Rizzo

The understanding of epidemics on networks has greatly benefited from the recent application of message-passing approaches, which allow to derive exact results for irreversible spreading (i.e. diseases with permanent acquired immunity) in…

Statistical Mechanics · Physics 2018-12-05 Claudio Castellano , Romualdo Pastor-Satorras

The study of infectious disease epidemiology for multi-type disease pathogens requires modelling techniques that account for the complex interactions existing between strains across geography and time. In this paper, we propose a novel…

Methodology · Statistics 2026-05-06 Matthew Adeoye , Simon E. F. Spencer , Xavier Didelot

Models of disease spreading are critical for predicting infection growth in a population and evaluating public health policies. However, standard models typically represent the dynamics of disease transmission between individuals using…

Physics and Society · Physics 2022-06-07 Christopher A. Browne , Daniel B. Amchin , Joanna Schneider , Sujit S. Datta

Infectious diseases are studied to understand their spreading mechanisms, to evaluate control strategies and to predict the risk and course of future outbreaks. Because people only interact with a small number of individuals, and because…

Applications · Statistics 2018-09-05 Ritabrata Dutta , Antonietta Mira , Jukka-Pekka Onnela

The ability to directly record human face-to-face interactions increasingly enables the development of detailed data-driven models for the spread of directly transmitted infectious diseases at the scale of individuals. Complete coverage of…

Pathogen genome data offers valuable structure for spatial models, but its utility is limited by incomplete sequencing coverage. We propose a probabilistic framework for inferring genetic distances between unsequenced cases and known…

Genomics · Quantitative Biology 2025-09-10 Haley Stone , Jing Du , Hao Xue , Matthew Scotch , David Heslop , Andreas Züfle , Chandini Raina MacIntyre , Flora Salim

Epidemic spreading of infectious diseases is ubiquitous and has often considerable impact on public health and economic wealth. The large variability in spatio-temporal patterns of epidemics prohibits simple interventions and demands for a…

Populations and Evolution · Quantitative Biology 2010-11-25 Christel Kamp

The structure of heterogeneous networks and human mobility patterns profoundly influence the spreading of endemic diseases. In small-scale communities, individuals engage in social interactions within confined environments, such as homes…

Physics and Society · Physics 2025-05-20 Yusheng Li , Yichao Yao , Minyu Feng , Tina P. Benko , Matjaž Perc , Jernej Završnik

The time variation of contacts in a networked system may fundamentally alter the properties of spreading processes and affect the condition for large-scale propagation, as encoded in the epidemic threshold. Despite the great interest in the…

Physics and Society · Physics 2015-04-14 Eugenio Valdano , Luca Ferreri , Chiara Poletto , Vittoria Colizza

We present a methodology providing a one-directional link from within-host individual heterogeneity to population-level disease transmission dynamics. The methodology works in several steps. A within-host model is investigated numerically…

Populations and Evolution · Quantitative Biology 2026-05-19 Julien Arino , Morgan Craig , Clotilde Djuikem , Kang-Ling Liao , Stéphanie Portet

Contacts between individuals play an important role in determining how infectious diseases spread. Various methods to gather data on such contacts co-exist, from surveys to wearable sensors. Comparisons of data obtained by different methods…

Physics and Society · Physics 2016-04-18 Julie Fournet , Alain Barrat

We couple a multi-type stochastic epidemic process with a directed random graph, where edges have random lengths. This random graph representation is used to characterise the fractions of individuals infected by the different types of…

Probability · Mathematics 2018-01-29 Tom Britton , Ka Yin Leung , Pieter Trapman