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We introduce a continuous-time Markov chain describing dynamic allelic partitions which extends the branching process construction of the Pitman sampling formula in Pitman (2006) and the birth-and-death process with immigration studied in…

Probability · Mathematics 2020-03-17 Matteo Giordano , Pierpaolo De Blasi , Matteo Ruggiero

Understanding patterns of selectively neutral genetic variation is essential in order to model deviations from neutrality, caused for example by different forms of selection. Best understood is neutral genetic variation at a single locus,…

Populations and Evolution · Quantitative Biology 2012-06-13 E. Schaper , A. Eriksson , M. Rafajlovic , S. Sagitov , B. Mehlig

Conventional population genetics considers the evolution of a limited number of genotypes corresponding to phenotypes with different fitness. As model phenotypes, in particular RNA secondary structure, have become computationally tractable,…

Populations and Evolution · Quantitative Biology 2008-04-22 Gergely J. Szollosi , Imre Derenyi

We investigate recurrence and transience of Branching Markov Chains (BMC) in discrete time. Branching Markov Chains are clouds of particles which move (according to an irreducible underlying Markov Chain) and produce offspring…

Probability · Mathematics 2016-09-07 Nina Gantert , Sebastian Mueller

A number of studies have suggested using comparisons between DNA sequences of closely related bacterial isolates to estimate the relative rate of recombination to mutation for that bacterial species. We consider such an approach which uses…

Applications · Statistics 2015-06-03 Paul Fearnhead , Shoukai Yu , Patrick Biggs , Barbara Holland , Nigel French

In many natural synchronization phenomena, communication between individual elements occurs not directly, but rather through the environment. One of these instances is bacterial quorum sensing, where bacteria release signaling molecules in…

Dynamical Systems · Mathematics 2015-05-18 Giovanni Russo , Jean-Jacques E. Slotine

This contribution is concerned with mathematical models for the dynamics of the genetic composition of populations evolving under recombination. Recombination is the genetic mechanism by which two parent individuals create the mixed type of…

Populations and Evolution · Quantitative Biology 2011-01-12 Ellen Baake

Consider a haploid population of fixed finite size with a finite number of allele types and having Cannings exchangeable genealogy with neutral mutation. The stationary distribution of the Markov chain of allele counts in each generation is…

Probability · Mathematics 2016-12-09 H. L. Gan , Adrian Röllin , Nathan Ross

In this article, we study branching random walks on graphs modeling division-mutation processes inspired by adaptive immunity. We apply the theory of expander graphs on mutation rules in evolutionary processes and obtain estimates for the…

Probability · Mathematics 2016-07-05 Irene Balelli , Vuk Milisic , Gilles Wainrib

Ordinary differential equation (ODE) models used in mathematical epidemiology assume explicitly or implicitly large populations. For the study of infections in a hospital this is an extremely restrictive assumption as typically a hospital…

Populations and Evolution · Quantitative Biology 2023-08-21 Fabio A. C. C. Chalub , Antonio Gómez-Corral , Martín López-García , Fátima Palacios-Rodríguez

In the human genomes, recombination frequency between homologous chromosomes during meiosis is highly correlated with their physical length while it differs significantly when their coding density is considered. Furthermore, it has been…

Populations and Evolution · Quantitative Biology 2010-02-01 Dorota Mackiewicz , Marta Zawierta , Wojciech Waga , Stanislaw Cebrat

We model the growth of a cell population using a piecewise deterministic Markov branching tree. In this model, each cell splits into two offspring at a division rate $B(x)$, which depends on its size $x$. The size of each cell increases…

Probability · Mathematics 2024-09-06 Nathalie Krell

Fluctuating environments pose tremendous challenges to bacterial populations. It is observed in numerous bacterial species that individual cells can stochastically switch among multiple phenotypes for the population to survive in rapidly…

Molecular Networks · Quantitative Biology 2015-01-20 Chen Jia , Min-Ping Qian , Yu Kang , Da-Quan Jiang

In this paper we introduce and discuss kinetic equations for the evolution of the probability distribution of the number of particles in a population subject to binary interactions. The microscopic binary law of interaction is assumed to be…

Probability · Mathematics 2015-01-13 Federico Bassetti , Giuseppe Toscani

Bacteria and their bacteriophages are the most abundant, widespread and diverse groups of biological entities on the planet. In an attempt to understand how the interactions between bacteria, virulent phages and temperate phages might…

Populations and Evolution · Quantitative Biology 2009-11-13 Martin Rosvall , Ian B. Dodd , Sandeep Krishna , Kim Sneppen

In this paper, we consider the evolution of an (infinitely large) population under recombination and additional evolutionary forces, modelled by a measure-valued ordinary differential equation. We provide a stochastic representation for the…

Probability · Mathematics 2024-10-03 Frederic Alberti

In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can…

Populations and Evolution · Quantitative Biology 2013-12-19 D. B. Weissman , O. Hallatschek

If we follow an asexually reproducing population through time, then the amount of time that has passed since the most recent common ancestor (MRCA) of all current individuals lived will change as time progresses. The resulting "MRCA age"…

Probability · Mathematics 2010-01-13 Steven N. Evans , Peter L. Ralph

In many complex systems, the dynamic processes that take place on a network and the changes in the network topology are intertwined. Here, we propose a model of coevolutionary dynamics of information spreading which is accompanied with link…

Physics and Society · Physics 2023-11-01 Jeehye Choi , Byungjoon Min

We consider a stationary continuous model of random size population with non-neutral mutations using a continuous state branching process with non-homogeneous immigration. We assume the type (or mutation) of the immigrants is random given…

Probability · Mathematics 2013-07-26 Hongwei Bi , Jean-François Delmas