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The spread of infectious disease and the evolution of antigenically distinct strains are often modeled separately, despite strong feedbacks mediated by host immune memory and heterogeneous contacts. To tackle this challenging problem, we…

Populations and Evolution · Quantitative Biology 2026-04-01 Davide Zanchetta , Vittoria Bettio , Sandro Azaele , Manlio De Domenico

Horizontal gene transfer (HGT) is an important process in bacterial evolution. Current phylogeny-based approaches to capture it cannot however appropriately account for the fact that HGT can occur between bacteria living in different…

Populations and Evolution · Quantitative Biology 2025-03-31 Katharina T. Huber , Darren Overman

Recent single molecule experiments probing the passage process of a short single-stranded DNA (ssDNA) through a membrane channel (translocation) allow to measure the passage time distribution. Building on a recent modelling approach (D. K.…

Statistical Mechanics · Physics 2009-11-10 Ralf Metzler , Joseph Klafter

The structure of molecular networks derives from dynamical processes on evolutionary time scales. For protein interaction networks, global statistical features of their structure can now be inferred consistently from several…

Statistical Mechanics · Physics 2007-05-23 Johannes Berg , Michael Lässig , Andreas Wagner

Textual analysis of typical microbial genomes reveals that they have the statistical characteristics of a DNA sequence of a much shorter length. This peculiar property supports an evolutionary model in which a genome evolves by random…

Biological Physics · Physics 2009-11-07 L. C. Hsieh , L. F. Luo , F. M. Ji , H. C. Lee

The homogeneous reconstructed evolutionary process is a birth-death process without observed extinct lineages. Each species evolves independently with the same diversification rates (speciation rate $\lambda(t)$ and extinction rate…

Populations and Evolution · Quantitative Biology 2014-02-12 Sebastian Höhna

Source-sink systems are metapopulations of patches that can be of variable habitat quality. They can be seen as graphs, where vertices represent the patches, and the weighted oriented edges give the probability of dispersal from one patch…

Probability · Mathematics 2011-11-11 Vincent Bansaye , Amaury Lambert

Ideas, behaviors, and opinions spread through social networks. If the probability of spreading to a new individual is a non-linear function of the fraction of the individuals' affected neighbors, such a spreading process becomes a "complex…

Physics and Society · Physics 2023-08-30 Julian Kates-Harbeck , Michael M. Desai

Human communication systems, such as language, evolve culturally; their components undergo reproduction and variation. However, a role for selection in cultural evolutionary dynamics is less clear. Often neutral evolution (also known as…

Social and Information Networks · Computer Science 2014-07-01 Nicolas Fay , Monica Tamariz , T Mark Ellison , Dale Barr

The propagation of infectious diseases and its impact on individuals play a major role in disease dynamics, and it is important to incorporate population heterogeneity into efforts to study diseases. As a simplistic but illustrative…

Populations and Evolution · Quantitative Biology 2019-07-24 Juan G. Calvo , Alberto Hernández , Mason A. Porter , Fabio Sanchez

Pathogenic bacteria present a large disease burden on human health. Control of these pathogens is hampered by rampant lateral gene transfer, whereby pathogenic strains may acquire genes conferring resistance to common antibiotics. Here we…

Populations and Evolution · Quantitative Biology 2014-06-06 Kevin J. Emmett , Raul Rabadan

The Moran model with recombination is considered, which describes the evolution of the genetic composition of a population under recombination and resampling. There are $n$ sites (or loci), a finite number of letters (or alleles) at every…

Probability · Mathematics 2018-11-01 Mareike Esser , Sebastian Probst , Ellen Baake

This article partakes of the PEGASE project the goal of which is a better understanding of the mechanisms explaining the behaviour of species living in a network of forest patches linked by ecological corridors (hedges for instance).…

Probability · Mathematics 2021-09-15 Gauthier Delvoye , Olivier Goubet , Frédéric Paccaut

Some species exhibit very high levels of DNA sequence variability; there is also evidence for the existence of heritable epigenetic variants that experience state changes at a much higher rate than sequence variants. In both cases, the…

Populations and Evolution · Quantitative Biology 2016-01-13 Brian Charlesworth , Kavita Jain

Natural selection and random drift are competing phenomena for explaining the evolution of populations. Combining a highly fit mutant with a population structure that improves the odds that the mutant spreads through the whole population…

Populations and Evolution · Quantitative Biology 2009-08-14 Valmir C. Barbosa , Raul Donangelo , Sergio R. Souza

Solving the recombination equation has been a long-standing challenge of \emph{deterministic} population genetics. We review recent progress obtained by introducing ancestral processes, as traditionally used in the context of…

Probability · Mathematics 2021-06-30 Ellen Baake , Michael Baake

Related groups of microbes are widely distributed across Earth's habitats, implying numerous dispersal and adaptation events over evolutionary time. However, to date, relatively little is known about the characteristics and mechanisms of…

Populations and Evolution · Quantitative Biology 2023-02-02 Alexander L. Jaffe , Cindy J. Castelle , Jillian F. Banfield

Phylogenetics uses alignments of molecular sequence data to learn about evolutionary trees. Substitutions in sequences are modelled through a continuous-time Markov process, characterised by an instantaneous rate matrix, which standard…

Populations and Evolution · Quantitative Biology 2020-07-20 Naomi E. Hannaford , Sarah E. Heaps , Tom M. W. Nye , Tom A. Williams , T. Martin Embley

To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare. But if…

Populations and Evolution · Quantitative Biology 2014-03-25 Richard A. Neher

Many seemingly disparate Markov chains are unified when viewed as random walks on the set of chambers of a hyperplane arrangement. These include the Tsetlin library of theoretical computer science and various shuffling schemes. If only…

Combinatorics · Mathematics 2010-02-08 Christos A. Athanasiadis , Persi Diaconis
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