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We report a realization of an associative memory signal/information processing system based on simple enzyme-catalyzed biochemical reactions. Optically detected chemical output is always obtained in response to the triggering input, but the…

Molecular Networks · Quantitative Biology 2013-04-23 Vera Bocharova , Kevin MacVittie , Soujanya Chinnapareddy , Jan Halamek , Vladimir Privman , Evgeny Katz

A famous biologically inspired hierarchical model firstly proposed by Riesenhuber and Poggio has been successfully applied to multiple visual recognition tasks. The model is able to achieve a set of position- and scale-tolerant recognition,…

Artificial Intelligence · Computer Science 2013-07-05 Qiao Hong , Li Yinlin , Tang Tang , Wang Peng

Associative learning is one of the key mechanisms displayed by living organisms in order to adapt to their changing environments. It was early recognized to be a general trait of complex multicellular organisms but also found in "simpler"…

Cell Behavior · Quantitative Biology 2017-01-24 Javier Macia , Blai Vidiella , Ricard Sole

We consider possible designs and experimental realiza-tions in synthesized rather than naturally occurring bio-chemical systems of a selection of basic bio-inspired information processing steps. These include feed-forward loops, which have…

Molecular Networks · Quantitative Biology 2015-02-09 Vladimir Privman , Evgeny Katz

Active systems across scales, ranging from molecular machines to human crowds, are usually modeled as assemblies of self-propelled particles driven by internally generated forces. However, these models often assume memoryless dynamics and…

Statistical Mechanics · Physics 2025-12-10 Marc Besse , Raphaël Voituriez

Understanding the binding dynamics of liquid molecules is of fundamental importance in physical and life sciences. However, nanoscale fast dynamics pose great challenges for experimental characterization. Conventionally, the binding…

Chemical Physics · Physics 2024-10-28 Shiyi Qin , Zhi Yang , Huimin Liu , Xiaoli Wang , Shangguo Hou , Kai Huang

Several abilities of biological systems, such as adaptation to natural environment, or of animals to learn patterns when appropriately trained, are features that are extremely useful, if emulated by electronic circuits, in applications…

Neurons and Cognition · Quantitative Biology 2011-12-22 M. Di Ventra , Y. V. Pershin

Multienzyme cascaded reactions are widely utilized because they can generate value-added biomaterials and biodevices from simple raw materials. However, how to promote the catalytic efficiency and synergistic effect of the multienzyme…

Biological Physics · Physics 2021-01-27 Zhexu Xi

Memories are stored, retained, and recollected through complex, coupled processes operating on multiple timescales. To understand the computational principles behind these intricate networks of interactions we construct a broad class of…

Neurons and Cognition · Quantitative Biology 2015-07-29 Marcus K. Benna , Stefano Fusi

We report the first study of a network of connected enzyme-catalyzed reactions, with added chemical and enzymatic processes that incorporate the recently developed biochemical filtering steps into the functioning of this biocatalytic…

Molecular Networks · Quantitative Biology 2013-12-17 Vladimir Privman , Oleksandr Zavalov , Lenka Halamkova , Fiona Moseley , Jan Halamek , Evgeny Katz

The majority of mammalian genomic transcripts do not directly code for proteins and it is currently believed that most of these are not under evolutionary constraint. However given the abundance non-coding RNA (ncRNA) and its strong…

Molecular Networks · Quantitative Biology 2016-08-22 J. M. Deutsch

Adaptive response to a varying environment is a common feature of biological organisms. Reproducing such features in electronic systems and circuits is of great importance for a variety of applications. Here, we consider memory models…

Cell Behavior · Quantitative Biology 2013-10-29 Fabio Lorenzo Traversa , Yuriy V. Pershin , Massimiliano Di Ventra

The entropic associative memory (EAM) is a computational model of natural memory incorporating some of its putative properties of being associative, distributed, declarative, abstractive and constructive. Previous experiments satisfactorily…

Machine Learning · Computer Science 2024-05-22 Noé Hernández , Rafael Morales , Luis A. Pineda

We introduce a near-term experimental platform for realizing an associative memory. It can simultaneously store many memories by using spinful bosons coupled to a degenerate multimode optical cavity. The associative memory is realized by a…

Large language models lack persistent, structured memory for long-term interaction and context-sensitive retrieval. Expanding context windows does not solve this: recent evidence shows that context length alone degrades reasoning by up to…

Computation and Language · Computer Science 2026-04-01 Diego C. Lerma-Torres

We review enzymatic systems which involve biocatalytic reactions utilized for information processing (biocomputing). Extensive ongoing research in biocomputing, mimicking Boolean logic gates has been motivated by potential applications in…

Biological Physics · Physics 2010-10-12 Evgeny Katz , Vladimir Privman

Alzheimer's Disease (AD) research has shifted to focus on biomarker trajectories and their potential use in understanding the underlying AD-related pathological process. A conceptual framework was proposed in modern AD research that…

Applications · Statistics 2024-09-12 Zhuojun Tang , Yuxin Zhu , Kexin Zhang , Zheyu Wang

Humans learn and form memories in stochastic environments. Auto-associative memory systems model these processes by storing patterns and later recovering them from corrupted versions. Here, memories are learned by associating each pattern…

Systems and Control · Electrical Eng. & Systems 2026-04-02 Qin He , Jing Shuang Li

A mechanism of memories, especially biological memories, is studied in terms of quantum fluids. Two-dimensional flows in central potentials $V_a(\rho)=-a^2g_a\rho^{2(a-1)}$ ($a\not=0$ and $\rho=\sqrt{x^2+y^2}$) have zero-energy eigenstates…

Biological Physics · Physics 2016-09-08 Tsunehiro Kobayashi

The brain has computational capabilities that surpass those of modern systems, being able to solve complex problems efficiently in a simple way. Neuromorphic engineering aims to mimic biology in order to develop new systems capable of…

Neural and Evolutionary Computing · Computer Science 2023-10-10 Daniel Casanueva-Morato , Alvaro Ayuso-Martinez , Juan P. Dominguez-Morales , Angel Jimenez-Fernandez , Gabriel Jimenez-Moreno
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