Related papers: Linearized eigenvalues for a free boundary problem…
This paper is devoted to the proof of the existence of the principal eigenvalue and related eigenfunctions for fully nonlinear degenerate or singular uniformly elliptic equations posed in a punctured ball, in presence of a singular…
In the present work, we develop a comprehensive and rigorous analytical framework for a non-local phase-field model that describes tumour growth dynamics. The model is derived by coupling a non-local Cahn-Hilliard equation with a parabolic…
A considerable number of research works has been devoted to the study of tumor models. Several biophysical factors, such as cell proliferation, apoptosis, chemotaxis, angiogenesis and necrosis, have been discovered to have an impact on the…
The nonlinear Schroedinger model is a prototypical dispersive wave equation that features finite time blowup, either for supercritical exponents (for fixed dimension) or for supercritical dimensions (for fixed nonlinearity exponent). Upon…
We study the rate of convergence for (variational) eigenvalues of several non-linear problems involving oscillating weights and subject to different kinds of boundary conditions in bounded domains.
We develop numerical algorithms to approximate positive solutions of elliptic boundary value problems with superlinear subcritical nonlinearity on the boundary of the form $-\Delta u + u = 0$ in $\Omega$ with $\frac{\partial u}{\partial…
We study a tumor growth model in two space dimensions, where proliferation of the tumor cells leads to expansion of the tumor domain and migration of surrounding normal tissues into the exterior vacuum. The model features two moving…
We present a complete description on the spectrum and eigenfunctions of the following two point boundary value problem $$(p(x)f')'-(q(x)-\lambda r(x))f=0\;, \;\; 0<x<L \quad ; \quad f'(0)=(\alpha_{1} \lambda + \alpha_{2}) f(0) \quad ; \quad…
In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…
In the paper we develop a general theory of solvability of linear inhomogeneous boundary-value problems for systems of first-order ordinary differential equations in spaces of smooth functions on a finite interval. This problems are set…
In this paper, we study a nonlinearly coupled initial-boundary value problem describing the evolution of brain tumor growth including lactate metabolism. In our modeling approach, we also take into account the viscoelastic properties of the…
In this paper, we investigate the tumor instability by employing both analytical and numerical techniques to validate previous results and extend the analytical findings presented in a prior study by Feng et al 2023. Building upon the…
We capture optimal decay for the Mullins-Sekerka evolution, a nonlocal, parabolic free boundary problem from materials science. Our main result establishes convergence of BV solutions to the planar profile in the physically relevant case of…
In this paper, we study an optimal control problem for a nonlinear system of reaction-diffusion equations that constitutes a simplified and relaxed version of a thermodynamically consistent phase field model for tumor growth originally…
This paper treats a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis. The evolution of the tumor fraction is governed by a variational inequality corresponding to a double obstacle…
In this paper we consider generalized eigenvalue problems for a family of operators with a quadratic dependence on a complex parameter. Our model is $L(\lambda)=-\triangle +(P(x)-\lambda)^2$ in $L^2(\R^d)$ where $P$ is a positive elliptic…
We consider the linear eigenvalue problem \tag{1} -u" = \lambda u, \quad \text{on $(-1,1)$}, where $\lambda \in \mathbb{R}$, together with the general multi-point boundary conditions \tag{2} \alpha_0^\pm u(\pm 1) + \beta_0^\pm u'(\pm 1) =…
A highly nonlinear eigenvalue problem is studied in a Sobolev space with variable exponent. The Euler-Lagrange equation for the minimization of a Rayleigh quotient of two Luxemburg norms is derived. The asymptotic case with a "variable…
We consider a free boundary tumor model under the presence of angiogenesis and time delays in the process of proliferation, in which the cell location is incorporated. It is assumed that the tumor attracts blood vessels at a rate…
We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…