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Protein structure similarity search (PSSS), which tries to search proteins with similar structures, plays a crucial role across diverse domains from drug design to protein function prediction and molecular evolution. Traditional…

Machine Learning · Computer Science 2024-11-14 Jin Han , Wu-Jun Li

Robotic and animal mapping systems share many challenges and characteristics: they must function in a wide variety of environmental conditions, enable the robot or animal to navigate effectively to find food or shelter, and be…

Robotics · Computer Science 2017-12-25 Litao Yu , Adam Jacobson , Michael Milford

Images have become an important data source in many scientific and commercial domains. Analysis and exploration of image collections often requires the retrieval of the best subregions matching a given query. The support of such…

Databases · Computer Science 2010-03-09 Vishwakarma Singh , Arnab Bhattacharya , Ambuj K. Singh

Strong Lensing is a powerful probe of the matter distribution in galaxies and clusters and a relevant tool for cosmography. Analyses of strong gravitational lenses with Deep Learning have become a popular approach due to these astronomical…

Redescription mining is a data analysis technique that has found applications in diverse fields. The most used redescription mining approaches involve two phases: finding matching pairs among data attributes and extending the pairs. This…

Machine Learning · Computer Science 2024-11-22 Maiju Karjalainen , Esther Galbrun , Pauli Miettinen

In this work, we introduce CPLASS (Continuous Piecewise-Linear Approximation via Stochastic Search), an algorithm for detecting changes in velocity within multidimensional data. The one-dimensional version of this problem is known as the…

Methodology · Statistics 2026-01-15 Linh Do , Dat Do , Keisha J. Cook , Scott A. McKinley

Several modern genomic technologies, such as DNA-Methylation arrays, measure spatially registered probes that number in the hundreds of thousands across multiplechromosomes. The measured probes are by themselves less interesting…

Applications · Statistics 2016-11-16 John Nagorski , Genevera I. Allen

Applying machine learning to sensitive time-series data is often bottlenecked by the iteration loop: Performance depends strongly on preprocessing and architecture, yet training often has to run on-premise under strict data-local…

Indexing is an effective way to support efficient query processing in large databases. Recently the concept of learned index, which replaces or complements traditional index structures with machine learning models, has been actively…

Databases · Computer Science 2022-08-01 Yao Tian , Tingyun Yan , Xi Zhao , Kai Huang , Xiaofang Zhou

Machine learning methods are used to discover complex nonlinear relationships in biological and medical data. However, sophisticated learning models are computationally unfeasible for data with millions of features. Here we introduce the…

Metagenome assembly is the process of transforming a set of short, overlapping, and potentially erroneous DNA segments from environmental samples into the accurate representation of the underlying microbiomes's genomes. State-of-the-art…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-09-20 Evangelos Georganas , Rob Egan , Steven Hofmeyr , Eugene Goltsman , Bill Arndt , Andrew Tritt , Aydin Buluc , Leonid Oliker , Katherine Yelick

Identifying trendline visualizations with desired patterns is a common and fundamental data exploration task. Existing visual analytics tools offer limited flexibility and expressiveness for such tasks, especially when the pattern of…

Databases · Computer Science 2020-01-31 Tarique Siddiqui , Zesheng Wang , Paul Luh , Karrie Karahalios , Aditya Parameswaran

Spatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current analysis methods often struggle with…

Improving the mathematical reasoning capabilities of Large Language Models (LLMs) is critical for advancing artificial intelligence. However, access to extensive, diverse, and high-quality reasoning datasets remains a significant challenge,…

Computation and Language · Computer Science 2025-05-28 Yuyang Ding , Xinyu Shi , Xiaobo Liang , Juntao Li , Zhaopeng Tu , Qiaoming Zhu , Min Zhang

The identification of homologous gene families across multiple genomes is a central task in bacterial pangenomics traditionally requiring computationally demanding all-against-all comparisons. PanDelos addresses this challenge with an…

Genomics · Quantitative Biology 2025-10-29 Simone Colli , Emiliano Maresi , Vincenzo Bonnici

While scaling training compute has led to remarkable improvements in large language models (LLMs), scaling inference compute has not yet yielded analogous gains. We hypothesize that a core missing component is a lack of diverse LLM outputs,…

Machine Learning · Computer Science 2024-10-22 Evan Wang , Federico Cassano , Catherine Wu , Yunfeng Bai , Will Song , Vaskar Nath , Ziwen Han , Sean Hendryx , Summer Yue , Hugh Zhang

We propose a new approach for clustering DNA features using array CGH data from multiple tumor samples. We distinguish data-collapsing: joining contiguous DNA clones or probes with extremely similar data into regions, from clustering:…

Applications · Statistics 2010-12-21 Kyung In Kim , Etienne Roquain , Mark Van De Wiel

Post-training weight quantization is crucial for reducing the memory and inference cost of large language models (LLMs), yet pushing the average precision below 4 bits remains challenging due to highly non-uniform weight sensitivity and the…

Machine Learning · Computer Science 2026-02-23 Xinlin Li , Timothy Chou , Josh Fromm , Zichang Liu , Yunjie Pan , Christina Fragouli

Modern cloud databases present scaling as a binary decision: scale-out by adding nodes or scale-up by increasing per-node resources. This one-dimensional view is limiting because database performance, cost, and coordination overhead emerge…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-05 Shahir Abdullah , Syed Rohit Zaman

This paper provides a new similarity detection algorithm. Given an input set of multi-dimensional data points, where each data point is assumed to be multi-dimensional, and an additional reference data point for similarity finding, the…

Artificial Intelligence · Computer Science 2017-07-12 Yariv Aizenbud , Amir Averbuch , Gil Shabat , Guy Ziv