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Cryo-Electron Microscopy (Cryo-EM) is a Nobel prize-winning technology for determining the 3D structure of particles at near-atomic resolution. A fundamental step in the recovering of the 3D single-particle structure is to align its 2D…

Image and Video Processing · Electrical Eng. & Systems 2021-01-12 Koby Bibas , Gili Weiss-Dicker , Dana Cohen , Noa Cahan , Hayit Greenspan

Motivated by the task of 2-D classification in single particle reconstruction by cryo-electron microscopy (cryo-EM), we consider the problem of heterogeneous multireference alignment of images. In this problem, the goal is to estimate a…

Image and Video Processing · Electrical Eng. & Systems 2019-10-03 Chao Ma , Tamir Bendory , Nicolas Boumal , Fred Sigworth , Amit Singer

Cryogenic electron microscopy (cryo-EM) is an invaluable technique for determining high-resolution three-dimensional structures of biological macromolecules using transmission particle images. The inherent symmetry in these macromolecules…

Optimization and Control · Mathematics 2024-11-06 Qi Zhang , Chenglong Bao , Hai Lin , Mingxu Hu

Extracting discriminative local features that are invariant to imaging variations is an integral part of establishing correspondences between images. In this work, we introduce a self-supervised learning framework to extract discriminative…

Computer Vision and Pattern Recognition · Computer Science 2023-03-29 Jongmin Lee , Byungjin Kim , Seungwook Kim , Minsu Cho

In photon-limited imaging, the pixel intensities are affected by photon count noise. Many applications, such as 3-D reconstruction using correlation analysis in X-ray free electron laser (XFEL) single molecule imaging, require an accurate…

Computer Vision and Pattern Recognition · Computer Science 2019-12-18 Zhizhen Zhao , Lydia T. Liu , Amit Singer

Principal component analysis (PCA) plays an important role in the analysis of cryo-EM images for various tasks such as classification, denoising, compression, and ab-initio modeling. We introduce a fast method for estimating a compressed…

Numerical Analysis · Mathematics 2022-11-01 Nicholas F. Marshall , Oscar Mickelin , Yunpeng Shi , Amit Singer

In many computer vision and shape analysis tasks, practitioners are interested in learning from the shape of the object in an image, while disregarding the object's orientation. To this end, it is valuable to define a rotation-invariant…

Image and Video Processing · Electrical Eng. & Systems 2025-11-26 Adele Myers , Nina Miolane

PCA can be used for rotation invariant features, describing a shape with its $p_{ab}=E[(x_i-E[x_a])(x_b-E[x_b])]$ covariance matrix approximating shape by ellipsoid, allowing for rotation invariants like its traces of powers. However, real…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Jarek Duda

We introduce a framework for recovering an image from its rotationally and translationally invariant features based on autocorrelation analysis. This work is an instance of the multi-target detection statistical model, which is mainly used…

Image and Video Processing · Electrical Eng. & Systems 2022-03-03 Nicholas F. Marshall , Ti-Yen Lan , Tamir Bendory , Amit Singer

Cryo-electron microscopy nowadays often requires the analysis of hundreds of thousands of 2D images as large as a few hundred pixels in each direction. Here we introduce an algorithm that efficiently and accurately performs principal…

Computer Vision and Pattern Recognition · Computer Science 2015-12-16 Zhizhen Zhao , Yoel Shkolnisky , Amit Singer

Cryo-electron microscopy (cryo-EM) is capable of producing reconstructed 3D images of biomolecules at near-atomic resolution. As such, it represents one of the most promising imaging techniques in structural biology. However, raw cryo-EM…

Quantitative Methods · Quantitative Biology 2021-05-25 Nina Miolane , Frédéric Poitevin , Yee-Ting Li , Susan Holmes

We propose a new set of rotationally and translationally invariant features for image or pattern recognition and classification. The new features are cubic polynomials in the pixel intensities and provide a richer representation of the…

Computer Vision and Pattern Recognition · Computer Science 2011-11-09 Risi Kondor

Automatic image rotation estimation is a key preprocessing step in many vision pipelines. This task is challenging because angles have circular topology, creating boundary discontinuities that hinder standard regression methods. We present…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Maximilian Woehrer

We present an efficient and accurate algorithm for principal component analysis (PCA) of a large set of two dimensional images, and, for each image, the set of its uniform rotations in the plane and its reflection. The algorithm starts by…

Computer Vision and Pattern Recognition · Computer Science 2014-02-17 Zhizhen Zhao , Amit Singer

Magnetic resonance imaging (MRI) is a non-invasive medical imaging technique offering high-resolution 3D images and valuable insights into human tissue conditions. Even at present, the refinement of denoising methods for MRI remains a…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Shiao Li

In single-particle cryo-electron microscopy (cryo-EM), the efficient determination of orientation parameters for 2D projection images poses a significant challenge yet is crucial for reconstructing 3D structures. This task is complicated by…

Image and Video Processing · Electrical Eng. & Systems 2025-09-30 Szu-Chi Chung

The use of local detectors and descriptors in typical computer vision pipelines work well until variations in viewpoint and appearance change become extreme. Past research in this area has typically focused on one of two approaches to this…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Udit Singh Parihar , Aniket Gujarathi , Kinal Mehta , Satyajit Tourani , Sourav Garg , Michael Milford , K. Madhava Krishna

Semantic segmentation is an important branch of image processing and computer vision. With the popularity of deep learning, various convolutional neural networks have been proposed for pixel-level classification and segmentation tasks. In…

Computer Vision and Pattern Recognition · Computer Science 2025-05-01 Xinyu Xu , Huazhen Liu , Tao Zhang , Huilin Xiong , Wenxian Yu

A crucial step in single particle analysis (SPA) of cryogenic electron microscopy (Cryo-EM), 2D classification and alignment takes a collection of noisy particle images to infer orientations and group similar images together. Averaging…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Supawit Chockchowwat , Chandrajit L. Bajaj

A common task in single particle electron cryomicroscopy (cryo-EM) is the rigid alignment of images and/or volumes. In the context of images, a rigid alignment involves estimating the inner-product between one image of $N\times N$ pixels…

Numerical Analysis · Mathematics 2022-12-07 Aaditya V. Rangan
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