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Background: Tumour budding is an independent predictor of metastasis and prognosis in colorectal cancer and is a vital part of the pathology specification report. In a conventional pathological section observation process, pathologists have…

Medical Physics · Physics 2025-03-21 Yiyan Su , Ruiqing Sun , Yajing Wang , Yanfeng xi , Shaohui Zhang

The computational imaging technique of Fourier Ptychographic Microscopy (FPM) enables high-resolution imaging with a wide field of view and can serve as an extremely valuable tool, e.g. in the classification of cells in medical…

Image and Video Processing · Electrical Eng. & Systems 2025-08-25 Navya Sonal Agarwal , Jan Philipp Schneider , Kanchana Vaishnavi Gandikota , Syed Muhammad Kazim , John Meshreki , Ivo Ihrke , Michael Moeller

Ptychography is a popular imaging technique that combines diffractive imaging with scanning microscopy. The technique consists of a coherent beam that is scanned across an object in a series of overlapping positions, leading to reliable and…

Numerical Analysis · Mathematics 2024-08-08 Ricardo Parada , Samy Wu Fung , Stanley Osher

We study an approach to solving the phase retrieval problem as it arises in a phase-less imaging modality known as ptychography. In ptychography, small overlapping sections of an unknown sample (or signal, say $x_0\in \mathbb{C}^d$) are…

Numerical Analysis · Mathematics 2019-10-09 Brian Preskitt , Rayan Saab

Achieving high spatial resolution is the goal of many imaging systems. Designing a high-resolution lens with diffraction-limited performance over a large field of view remains a difficult task in imaging system design. On the other hand,…

Quantitative phase imaging (QPI) is a label-free computational imaging technique used in various fields, including biology and medical research. Modern QPI systems typically rely on digital processing using iterative algorithms for phase…

Optics · Physics 2023-06-28 Yuhang Li , Yi Luo , Deniz Mengu , Bijie Bai , Aydogan Ozcan

High-resolution imaging in the terahertz (THz) spectral range remains fundamentally constrained by the limited numerical apertures of currently existing state-of-the-art imagers, which restricts its applicability across many fields, such as…

This paper presents a microscopic imaging technique that uses variable-angle illumination to recover the complex polarimetric properties of a specimen at high resolution and over a large field-of-view. The approach extends Fourier…

This paper reported a general noninterferometric high-accuracy quantitative phase imaging (QPI) method for arbitrary complex valued objects. Given by a typical 4f optical configuration as the imaging system, three frames of small-window…

Image and Video Processing · Electrical Eng. & Systems 2021-05-05 Jianhui Huang , An Pan , Huiliang Jin , Guoxiang Meng , Qian Ye

Quantitative phase imaging (QPI) is important in many applications such as microscopy and crystallography. To quantitatively reveal phase information, people could either employ interference to map phase distribution into intensity fringes,…

Optics · Physics 2020-11-11 Xianye Li , Yafei sun , Yikang He , Xun Li , Baoqing Sun

Fourier ptychography is a recently explored imaging method for overcoming the diffraction limit of conventional cameras with applications in microscopy and yielding high-resolution images. In order to splice together low-resolution images…

Image and Video Processing · Electrical Eng. & Systems 2020-03-18 Yican Chen , Zhi Luo , Xia Wu , Huidong Yang , Bo Huang

Fourier Ptychography (FP) is a recently proposed technique for large field of view and high resolution imaging. Specifically, FP captures a set of low resolution images under angularly varying illuminations and stitches them together in…

Optics · Physics 2014-11-25 Liheng Bian , Jinli Suo , Guohai Situ , Guoan Zheng , Feng Chen , Qionghai Dai

We present a single-image numerical phase retrieval method for Zernike phase-contrast microscopy (ZPM) that addresses halo and shade-off artifacts, as well as the weak phase condition, without requiring hardware modifications. By employing…

Ptychography promises diffraction limited resolution without the need for high resolution lenses. To achieve high resolution one has to solve the phase problem for many partially overlapping frames. Here we review some of the existing…

Optics · Physics 2012-09-24 C. Yang , J. Qian , A. Schirotzek , F. Maia , S. Marchesini

Quantitative phase microscopy (QPM) is often based on recording an object-reference interference pattern and its further phase demodulation. We propose Pseudo Hilbert Phase Microscopy (PHPM) where we combine pseudo thermal light source…

We perform quantitative phase imaging using phase retrieval to implement synthetic aperture imaging. Compared to digital holography, the developed technique is simpler, less expensive, and more stable.

Optics · Physics 2016-09-07 Dennis J. Lee , Andrew M. Weiner

The structural complexity and instability of many interference phase microscopy methods are the major obstacles toward high-precision phase measurement. In this vein, improving more efficient configurations as well as proposing new methods…

Optics · Physics 2020-01-08 Samira Ebrahimi , Masoomeh Dashtdar

Fourier ptychography (FP), as a computational imaging method, is a powerful tool to improve imaging resolution. Camera-scanning Fourier ptychography extends the application of FP from micro to macro creatively. Due to the non-ideal scanning…

Image and Video Processing · Electrical Eng. & Systems 2022-06-08 Baiqi Cui , Shaohui Zhang , Yechao Wang , Yao Hu , Qun Hao

An approach reported recently by Alexandrov et al. on optical scatter imaging, termed digital Fourier microscopy (DFM), represents an adaptation of digital Fourier holography to selective imaging of biological matter. Holographic mode of…

Optics · Physics 2007-05-23 K. Y. T. Seet , P. Blazkiewicz , P. Meredith , A. V. Zvyagin

Ptychography is an imaging technique which involves a sample being illuminated by a coherent, localized probe of illumination. When the probe interacts with the sample, the light is diffracted and a diffraction pattern is detected. Then the…

Numerical Analysis · Mathematics 2023-01-31 Mark Iwen , Michael Perlmutter , Mark Philip Roach