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Biological networks are a very convenient modelling and visualisation tool to discover knowledge from modern high-throughput genomics and postgenomics data sets. Indeed, biological entities are not isolated, but are components of complex…

Quantitative Methods · Quantitative Biology 2018-05-07 Alex White , Matthieu Vignes

Heterogeneity in medical data, e.g., from data collected at different sites and with different protocols in a clinical study, is a fundamental hurdle for accurate prediction using machine learning models, as such models often fail to…

Machine Learning · Computer Science 2021-07-13 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

Discovering causal relations among observed variables in a given data set is a major objective in studies of statistics and artificial intelligence. Recently, some techniques to discover a unique causal model have been explored based on…

Machine Learning · Statistics 2014-01-23 Takanori Inazumi , Takashi Washio , Shohei Shimizu , Joe Suzuki , Akihiro Yamamoto , Yoshinobu Kawahara

Causal processes in biomedicine may contain cycles, evolve over time or differ between populations. However, many graphical models cannot accommodate these conditions. We propose to model causation using a mixture of directed cyclic graphs…

Machine Learning · Statistics 2020-09-08 Eric V. Strobl

In this work, we deepen on the use of normalizing flows for causal reasoning. Specifically, we first leverage recent results on non-linear ICA to show that causal models are identifiable from observational data given a causal ordering, and…

Machine Learning · Computer Science 2023-12-11 Adrián Javaloy , Pablo Sánchez-Martín , Isabel Valera

Learning causality from observational data has received increasing interest across various scientific fields. However, most existing methods assume the absence of latent confounders and restrict the underlying causal graph to be acyclic,…

Methodology · Statistics 2025-11-18 Wei Jin , Lang Lang , Amanda B. Spence , Leah H. Rubin , Yanxun Xu

Causal discovery is a fundamental problem with applications spanning various areas in science and engineering. It is well understood that solely using observational data, one can only orient the causal graph up to its Markov equivalence…

Machine Learning · Computer Science 2024-10-29 Zihan Zhou , Muhammad Qasim Elahi , Murat Kocaoglu

We consider the problem of learning causal directed acyclic graphs from an observational joint distribution. One can use these graphs to predict the outcome of interventional experiments, from which data are often not available. We show…

Machine Learning · Statistics 2016-08-18 Jonas Peters , Joris Mooij , Dominik Janzing , Bernhard Schölkopf

Estimating causal effects from observational data has become increasingly critical in diverse fields including healthcare, economics, and social policy. The fundamental challenge in causal inference arises from the missing counterfactuals…

Machine Learning · Computer Science 2026-05-08 Yifei Xie , Jian Huang

Structural causal models postulate noisy functional relations among a set of interacting variables. The causal structure underlying each such model is naturally represented by a directed graph whose edges indicate for each variable which…

Statistics Theory · Mathematics 2022-03-15 David Strieder , Tobias Freidling , Stefan Haffner , Mathias Drton

This paper proposes and evaluates a new performance estimation method that leverages continual learning (CL) algorithms to carry out sequential simulation experiments for a feedback-based molecular communication protocol. As the protocol is…

Machine Learning · Computer Science 2026-05-05 Siddhant Setia , Junichi Suzuki , Tadashi Nakano

Causal structure learning from observational data remains a non-trivial task due to various factors such as finite sampling, unobserved confounding factors, and measurement errors. Constraint-based and score-based methods tend to suffer…

Machine Learning · Computer Science 2022-11-09 Rezaur Rashid , Jawad Chowdhury , Gabriel Terejanu

One of the basic aims in science is to unravel the chain of cause and effect of particular systems. Especially for large systems this can be a daunting task. Detailed interventional and randomized data sampling approaches can be used to…

Methodology · Statistics 2016-11-30 Seyed Mahdi Mahmoudi , Ernst Wit

We address the problem of causal discovery from data, making use of the recently proposed causal modeling framework of modular structural causal models (mSCM) to handle cycles, latent confounders and non-linearities. We introduce…

Machine Learning · Statistics 2022-08-31 Patrick Forré , Joris M. Mooij

We posit that autoregressive flow models are well-suited to performing a range of causal inference tasks - ranging from causal discovery to making interventional and counterfactual predictions. In particular, we exploit the fact that…

Machine Learning · Statistics 2020-07-28 Ricardo Pio Monti , Ilyes Khemakhem , Aapo Hyvarinen

Identifying variables responsible for changes to a biological system enables applications in drug target discovery and cell engineering. Given a pair of observational and interventional datasets, the goal is to isolate the subset of…

Machine Learning · Computer Science 2025-06-02 Menghua Wu , Umesh Padia , Sean H. Murphy , Regina Barzilay , Tommi Jaakkola

Discovering causal relationships in complex multivariate time series is a fundamental scientific challenge. Traditional methods often falter, either by relying on restrictive linear assumptions or on conditional independence tests that…

Machine Learning · Computer Science 2025-08-05 Gian Marco Paldino , Gianluca Bontempi

Causal discovery from observational and interventional data is challenging due to limited data and non-identifiability: factors that introduce uncertainty in estimating the underlying structural causal model (SCM). Selecting experiments…

Machine Learning · Computer Science 2022-10-24 Panagiotis Tigas , Yashas Annadani , Andrew Jesson , Bernhard Schölkopf , Yarin Gal , Stefan Bauer

Biological networks are pivotal in deciphering the complexity and functionality of biological systems. Causal inference, which focuses on determining the directionality and strength of interactions between variables rather than merely…

Molecular Networks · Quantitative Biology 2025-11-05 Hongyang Jiang , Yuezhu Wang , Ke Feng , Chaoyi Yin , Yi Chang , Huiyan Sun

We consider linear non-Gaussian structural equation models that involve latent confounding. In this setting, the causal structure is identifiable, but, in general, it is not possible to identify the specific causal effects. Instead, a…

Machine Learning · Statistics 2024-08-12 Daniela Schkoda , Elina Robeva , Mathias Drton
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