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Understanding the relationships between different properties of data, such as whether a connectome or genome has information about disease status, is becoming increasingly important in modern biological datasets. While existing approaches…

Machine Learning · Statistics 2024-06-27 Joshua T. Vogelstein , Eric Bridgeford , Qing Wang , Carey E. Priebe , Mauro Maggioni , Cencheng Shen

The goal of importance sampling is to estimate the expected value of a given function with respect to a probability measure $\nu$ using a random sample of size $n$ drawn from a different probability measure $\mu$. If the two measures $\mu$…

Probability · Mathematics 2017-06-22 Sourav Chatterjee , Persi Diaconis

Given a model $f$ that predicts a target $y$ from a vector of input features $\pmb{x} = x_1, x_2, \ldots, x_M$, we seek to measure the importance of each feature with respect to the model's ability to make a good prediction. To this end, we…

Machine Learning · Computer Science 2019-10-03 Luke Merrick

Important information on the structure of complex systems, consisting of more than one component, can be obtained by measuring to which extent the individual components exchange information among each other. Such knowledge is needed to…

Disordered Systems and Neural Networks · Physics 2009-11-13 Daniele Marinazzo , Mario Pellicoro , Sebastiano Stramaglia

Understanding causal relationships among the variables of a system is paramount to explain and control its behavior. For many real-world systems, however, the true causal graph is not readily available and one must resort to predictions…

Machine Learning · Statistics 2024-12-20 Elias Eulig , Atalanti A. Mastakouri , Patrick Blöbaum , Michaela Hardt , Dominik Janzing

Increasing accessibility of data to researchers makes it possible to conduct massive amounts of statistical testing. Rather than follow a carefully crafted set of scientific hypotheses with statistical analysis, researchers can now test…

Genomics · Quantitative Biology 2016-09-08 Olga A. Vsevolozhskaya , Chia-Ling Kuo , Gabriel Ruiz , Luda Diatchenko , Dmitri V. Zaykin

The performance of machine learning classification algorithms are evaluated by estimating metrics, often from the confusion matrix, using training data and cross-validation. However, these do not prove that the best possible performance has…

Machine Learning · Statistics 2024-03-05 L. Crow , S. J. Watts

Testing fit of data to model is fundamentally important to any science, but publications in the field of phylogenetics rarely do this. Such analyses discard fundamental aspects of science as prescribed by Karl Popper. Indeed, not without…

Populations and Evolution · Quantitative Biology 2008-12-31 Peter J. Waddell , Rissa Ota , David Penny

Many researchers have identified distribution shift as a likely contributor to the reproducibility crisis in behavioral and biomedical sciences. The idea is that if treatment effects vary across individual characteristics and experimental…

Applications · Statistics 2023-09-06 Ying Jin , Kevin Guo , Dominik Rothenhäusler

Singular statistical models arise whenever different parameter values induce the same distribution, leading to non-identifiability and a breakdown of classical asymptotic theory. While existing approaches analyze these phenomena in…

Statistics Theory · Mathematics 2026-04-03 Sean Plummer

In this paper, a robust non-parametric measure of statistical dependence, or correlation, between two random variables is presented. The proposed coefficient is a permutation-like statistic that quantifies how much the observed sample S_n :…

Methodology · Statistics 2020-07-27 Rami Mahdi

In this paper, we investigate the convergence of language models (LMs) trained under different random seeds, measuring convergence as the expected per-token Kullback--Leibler (KL) divergence across seeds. By comparing LM convergence as a…

Computation and Language · Computer Science 2025-10-01 Finlay Fehlauer , Kyle Mahowald , Tiago Pimentel

We study categorical instrumental variable (IV) models with instrument, treatment, and outcome taking finitely many values. We derive a simple closed-form characterization of the set of joint distributions of potential outcomes that are…

Statistics Theory · Mathematics 2025-11-13 Yilin Song , F. Richard Guo , K. C. Gary Chan , Thomas S. Richardson

The inference of networks of dependencies by Gaussian Graphical models on high-throughput data is an open issue in modern molecular biology. In this paper we provide a comparative study of three methods to obtain small sample and high…

Molecular Networks · Quantitative Biology 2022-03-02 P. F. Stifanelli , T. M. Creanza , R. Anglani , V. C. Liuzzi , S. Mukherjee , N. Ancona

Random models of evolution are instrumental in extracting rates of microscopic evolutionary mechanisms from empirical observations on genetic variation in genome sequences. In this context it is necessary to know the statistical properties…

Biological Physics · Physics 2009-11-07 A. Eriksson , B. Haubold , B. Mehlig

Kullback-Leibler (KL) divergence is one of the most important divergence measures between probability distributions. In this paper, we prove several properties of KL divergence between multivariate Gaussian distributions. First, for any two…

Information Theory · Computer Science 2023-01-24 Yufeng Zhang , Wanwei Liu , Zhenbang Chen , Ji Wang , Kenli Li

Correlations play a pivotal role in various fields of science, particularly in quantum mechanics, yet their proper quantification remains a subject of debate. In this work, we aim to discuss the challenge of defining a reliable measure of…

Quantum Physics · Physics 2025-04-02 Gabriel L. Moraes , Renato M. Angelo , Ana C. S. Costa

In this paper, we study the strong consistency of a bias reduced kernel density estimator and derive a strongly con- sistent Kullback-Leibler divergence (KLD) estimator. As application, we formulate a goodness-of-fit test and an…

Methodology · Statistics 2018-05-21 Papa Ngom , Freedath Djibril Moussa , Jean de Dieu Nkurunziza

In a regression setup with deterministic design, we study the pure aggregation problem and introduce a natural extension from the Gaussian distribution to distributions in the exponential family. While this extension bears strong…

Machine Learning · Statistics 2012-06-06 Philippe Rigollet

This work presents an upper-bound to value that the Kullback-Leibler (KL) divergence can reach for a class of probability distributions called quantum distributions (QD). The aim is to find a distribution $U$ which maximizes the KL…

Machine Learning · Computer Science 2020-12-11 Vincenzo Bonnici
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