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Dose-finding trials are a key component of the drug development process and rely on a statistical design to help inform dosing decisions. Triallists wishing to choose a design require knowledge of operating characteristics of competing…

Computation · Statistics 2025-03-11 Michael Sweeting , Daniel Slade , Dan Jackson , Kristian Brock

Open-ended assignments - such as lab reports and semester-long projects - provide data science and statistics students with opportunities for developing communication, critical thinking, and creativity skills. However, providing grades and…

Other Statistics · Statistics 2025-01-15 Federica Zoe Ricci , Catalina Mari Medina , Mine Dogucu

Simulation models often have parameters as input and return outputs to understand the behavior of complex systems. Calibration is the process of estimating the values of the parameters in a simulation model in light of observed data from…

Methodology · Statistics 2024-11-15 Özge Sürer

This paper introduces the R package BayesVarSel which implements objective Bayesian methodology for hypothesis testing and variable selection in linear models. The package computes posterior probabilities of the competing hypotheses/models…

Other Statistics · Statistics 2016-11-28 Gonzalo Garcia-Donato , Anabel Forte

Parallel computing is a standard approach to achieving high-performance computing (HPC). Three commonly used methods to implement parallel computing include: 1) applying multithreading technology on single-core or multi-core CPUs; 2)…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-09-18 Xinyao Yi

The past decade has witnessed a dramatic increase in the size and scope of biological and behavioral experiments. These experiments are providing an unprecedented level of detail and depth of data. However, this increase in data presents…

Quantitative Methods · Quantitative Biology 2014-04-03 Samuel V. Scarpino , Ross Gillette , David Crews

Monitoring the quality of statistical processes has been of great importance, mostly in industrial applications. Control charts are widely used for this purpose, but often lack the possibility to monitor survival outcomes. Recently,…

Applications · Statistics 2024-06-19 Daniel Gomon , Marta Fiocco , Hein Putter , Mirko Signorelli

The use of Bayesian adaptive designs for randomised controlled trials has been hindered by the lack of software readily available to statisticians. We have developed a new software package (Bayesian Adaptive Trials Simulator Software -…

We present RKappa, a framework for the development and analysis of rule-based models within a mature, statistically empowered R environment. The infrastructure allows model editing, modification, parameter sampling, simulation, statistical…

Molecular Networks · Quantitative Biology 2014-12-16 Anatoly Sorokin , Oksana Sorokina , J. Douglas Armstrong

We consider parallel computation for Gaussian process calculations to overcome computational and memory constraints on the size of datasets that can be analyzed. Using a hybrid parallelization approach that uses both threading (shared…

The numerical availability of statistical inference methods for a modern and robust analysis of longitudinal- and multivariate data in factorial experiments is an essential element in research and education. While existing approaches that…

Computation · Statistics 2018-01-25 Sarah Friedrich , Frank Konietschke , Markus Pauly

We present a bayesassurance R package that computes the Bayesian assurance under various settings characterized by different assumptions and objectives. The package offers a constructive set of simulation-based functions suitable for…

Methodology · Statistics 2022-03-30 Jane Pan , Sudipto Banerjee

Simulated high-dimensional data is useful for testing, validating, and improving algorithms used in dimension reduction, supervised and unsupervised learning. High-dimensional data is characterized by multiple variables that are dependent…

Simulations are valuable tools for empirically evaluating the properties of statistical methods and are primarily employed in methodological research to draw general conclusions about methods. In addition, they can often be useful to…

Other Statistics · Statistics 2025-10-08 Anne-Laure Boulesteix , Patrick Callahan , Luzia Hanssum , Vincent Gaertner , Eva Hoster

We describe a system that simplifies the process of debugging programs produced by computer-aided parallelization tools. The system uses relative debugging techniques to compare serial and parallel executions in order to show where the…

Software Engineering · Computer Science 2007-05-23 Robert Hood , Gabriele Jost

The aim of the plsRglm package is to deal with complete and incomplete datasets through several new techniques or, at least, some which were not yet implemented in R. Indeed, not only does it make available the extension of the PLS…

Computation · Statistics 2018-10-03 F. Bertrand , M. Maumy-Bertrand

Due to the increasing availability of high-dimensional empirical applications in many research disciplines, valid simultaneous inference becomes more and more important. For instance, high-dimensional settings might arise in economic…

Econometrics · Economics 2018-09-14 Philipp Bach , Victor Chernozhukov , Martin Spindler

Generating artificial data is a crucial step when performing Monte-Carlo simulation studies. Depending on the planned study, complex data generation processes (DGP) containing multiple, possibly time-varying, variables with various forms of…

Methodology · Statistics 2025-06-03 Robin Denz , Nina Timmesfeld

An increasing volume of studies utilize geocomputation methods in large spatial data. There is a bottleneck in scalable computation for general scientific use as the existing solutions require high-performance computing domain knowledge and…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-06 Insang Song , Kyle P. Messier

The interAdapt R package is designed to be used by statisticians and clinical investigators to plan randomized trials. It can be used to determine if certain adaptive designs offer tangible benefits compared to standard designs, in the…

Applications · Statistics 2014-06-19 Aaron Fisher , Harris Jaffee , Michael Rosenblum