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The genetic diversity of a species is shaped by its recent evolutionary history and can be used to infer demographic events or selective sweeps. Most inference methods are based on the null hypothesis that natural selection is a weak or…

Populations and Evolution · Quantitative Biology 2013-03-05 Richard A. Neher , Oskar Hallatschek

A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of…

Populations and Evolution · Quantitative Biology 2013-02-04 Lee Altenberg

Our models for detecting the effect of adaptation on population genomic diversity are often predicated on a single newly arisen mutation sweeping rapidly to fixation. However, a population can also adapt to a new situation by multiple…

Populations and Evolution · Quantitative Biology 2012-07-26 Peter Ralph , Graham Coop

Evolution is simultaneously driven by a number of processes such as mutation, competition and random sampling. Understanding which of these processes is dominating the collective evolutionary dynamics in dependence on system properties is a…

Populations and Evolution · Quantitative Biology 2012-09-13 Hinrich Arnoldt , Marc Timme , Stefan Grosskinsky

Many species are unsustainable at small population densities (Allee Effect), i.e., below a threshold named Allee threshold, the population decreases instead of growing. In a closed local population, environmental fluctuations always lead to…

Populations and Evolution · Quantitative Biology 2022-01-27 Rodrigo Crespo , Javier Jarillo , Francisco J. Cao-García

We study a family of selection-mutation models of a sexual population structured by a phenotypical trait. The main feature of these models is the asymmetric trait heredity or fecundity between the parents : we assume that each individual…

Analysis of PDEs · Mathematics 2022-04-11 Benoît Perthame , Martin Strugarek , Cécile Taing

We study simple mathematical models of gene expression to explore the possible origins of haploinsufficiency (HI). In a diploid organism, each gene exists in two copies and when one of these is mutated, the amount of proteins synthesized is…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Indrani Bose , Rajesh Karmakar

We study the evolution of the network properties of a populated network embedded in a genotype space characterised by either a low or a high number of potential links, with particular emphasis on the connectivity and clustering. Evolution…

Statistical Mechanics · Physics 2007-05-23 Paul Anderson , Henrik Jeldtoft Jensen

In the Admixture Model, the probability of an individual having a certain number of alleles at a specific marker depends on the allele frequencies in $K$ ancestral populations and the fraction of the individual's genome originating from…

Applications · Statistics 2025-07-29 Carola Sophia Heinzel

Evolutionary systems must learn to generalize, often extrapolating from a limited set of selective conditions to anticipate future environmental changes. The mechanisms enabling such generalization remain poorly understood, despite their…

Populations and Evolution · Quantitative Biology 2025-10-29 Federica Ferretti , Mehran Kardar , Arvind Murugan

A probabilistic reconstruction of genealogies in a polyploid population (from 2x to 4x) is investigated, by considering genetic data analyzed as the probability of allele presence in a given genotype. Based on the likelihood of all possible…

Populations and Evolution · Quantitative Biology 2018-11-29 Frédéric Proïa , Fabien Panloup , Chiraz Trabelsi , Jérémy Clotault

A classical view of speciation is that reproductive isolation arises as a by-product of genetic divergence. Here, individual-based simulations are used to evaluate whether the mechanisms implied by this view may result in rapid speciation…

adap-org · Physics 2007-05-23 Sergey Gavrilets , Hai Li , Michael D. Vose

We study a continuous-time dynamical system that models the evolving distribution of genotypes in an infinite population where genomes may have infinitely many or even a continuum of loci, mutations accumulate along lineages without…

Populations and Evolution · Quantitative Biology 2009-02-03 Aubrey Clayton , Steven N. Evans

Two mathematical models of macroevolution are studied. These models have population dynamics at the species level, and mutations and extinction of species are also included. The population dynamics are updated by difference equations with…

Populations and Evolution · Quantitative Biology 2014-04-16 Yohsuke Murase , Takashi Shimada , Nobuyasu Ito , Per Arne Rikvold

Interacting populations often create complicated spatiotemporal behavior, and understanding it is a basic problem in the dynamics of spatial systems. We study the two-species case by simulations of a host--parasitoid model. In the case of…

Populations and Evolution · Quantitative Biology 2009-01-16 Matti Peltomaki , Martin Rost , Mikko Alava

We consider the dynamics of two coupled three-species population patches, incorporating the Allee Effect, focussing on the onset of extreme events in the coupled system. First we show that the interplay between coupling and the Allee effect…

Populations and Evolution · Quantitative Biology 2021-10-05 Deeptajyoti Sen , Sudeshna Sinha

We present a study by linear stability analysis and large-scale Monte Carlo simulations of a simple model of biological coevolution. Selection is provided through a reproduction probability that contains quenched, random interspecies…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Per Arne Rikvold , R. K. P. Zia

Two important problems affect the ability of asexual populations to accumulate beneficial mutations, and hence to adapt. First, clonal interference causes some beneficial mutations to be outcompeted by more-fit mutations which occur in the…

Populations and Evolution · Quantitative Biology 2008-04-08 Craig A. Fogle , James L. Nagle , Michael M. Desai

Consider a genetic locus carrying a strongly beneficial allele which has recently fixed in a large population. As strongly beneficial alleles fix quickly, sequence diversity at partially linked neutral loci is reduced. This phenomenon is…

Populations and Evolution · Quantitative Biology 2007-05-23 P. Pfaffelhuber , A. Studeny

Selective sweeps are typically associated with a local reduction of genetic diversity around the adaptive site. However, selective sweeps can also quickly carry neutral mutations to observable population frequencies if they arise early in a…

Populations and Evolution · Quantitative Biology 2012-06-29 Philipp W. Messer , Richard A. Neher