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We model and study the genetic evolution and conservation of a population of diploid hermaphroditic organisms, evolving continuously in time and subject to resource competition. In the absence of mutations, the population follows a 3-type…

Probability · Mathematics 2012-07-23 Camille Coron

Species growing in environments that change in time and space will vary in their abundance across locations, even in the absence of persistent location preferences. Here we quantify this non-equilibrium effect by studying a minimal model of…

Populations and Evolution · Quantitative Biology 2026-03-04 James F. D. Henderson , Andreas Tiffeau-Mayer

The sample frequency spectrum of a segregating site is the probability distribution of a sample of alleles from a genetic locus, conditional on observing the sample to have more than one clearly different phenotypes. We present a model for…

Probability · Mathematics 2014-05-13 Arka Bhattacharya

Both genetic drift and natural selection cause the frequencies of alleles in a population to vary over time. Discriminating between these two evolutionary forces, based on a time series of samples from a population, remains an outstanding…

Populations and Evolution · Quantitative Biology 2013-12-09 Alison Feder , Sergey Kryazhimskiy , Joshua B. Plotkin

We have simulated the evolution of age structured populations whose individuals represented by their diploid genomes were distributed on a square lattice. The environmental conditions on the whole territory changed simultaneously in the…

Populations and Evolution · Quantitative Biology 2009-11-05 Wojciech Waga , Marta Zawierta , Stanislaw Cebrat

Many experimental and field studies have shown that adaptation can occur very rapidly. Two qualitatively different modes of fast adaptation have been proposed: selective sweeps wherein large shifts in the allele frequencies occur at a few…

Populations and Evolution · Quantitative Biology 2018-10-19 Kavita Jain , Wolfgang Stephan

In sexual populations, selection operates neither on the whole genome, which is repeatedly taken apart and reassembled by recombination, nor on individual alleles that are tightly linked to the chromosomal neighborhood. The resulting…

Populations and Evolution · Quantitative Biology 2014-03-25 Richard A. Neher , Taylor A. Kessinger , Boris I. Shraiman

The shape of allele-frequency clines maintained by migration-selection balance depends not only on the properties of migration and selection, but also on the dominance relations among alleles and on linkage to other loci under selection. We…

Populations and Evolution · Quantitative Biology 2018-12-18 Reinhard Bürger

In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can…

Populations and Evolution · Quantitative Biology 2013-12-19 D. B. Weissman , O. Hallatschek

Gene duplication is believed to play a major role in the evolution of genomic complexity. The presence of a duplicate removes the constraint of natural selection upon the gene, leading to its likely loss of function or, occasionally, the…

Molecular Networks · Quantitative Biology 2015-05-06 Srinandan Dasmahapatra

Natural populations often show enhanced genetic drift consistent with a strong skew in their offspring number distribution. The skew arises because the variability of family sizes is either inherently strong or amplified by population…

Populations and Evolution · Quantitative Biology 2022-01-13 Takashi Okada , Oskar Hallatschek

Between-species coevolution, and in particular antagonistic host-parasite coevolution, is a major process shaping within-species diversity. In this paper we investigate the role of various stochastic processes affecting the outcome of the…

Populations and Evolution · Quantitative Biology 2020-12-08 Wolfgang Stephan , Aurélien Tellier

In considering evolution of transcribed regions, regulatory modules, and other genomic loci of interest, we are often faced with a situation in which the number of allelic states greatly exceeds the population size. In this limit, the…

Populations and Evolution · Quantitative Biology 2016-07-27 Pavel Khromov , Constantin D. Malliaris , Alexandre V. Morozov

Positive selection distorts the structure of genealogies and hence alters patterns of genetic variation within a population. Most analyses of these distortions focus on the signatures of hitchhiking due to hard or soft selective sweeps at a…

Populations and Evolution · Quantitative Biology 2012-08-17 Michael M. Desai , Aleksandra M. Walczak , Daniel S. Fisher

We review models of biological evolution in which the population frequency changes deterministically with time. If the population is self-replicating, although the equations for simple prototypes can be linearised, nonlinear equations arise…

Populations and Evolution · Quantitative Biology 2015-05-27 Kavita Jain , Sarada Seetharaman

Large populations may contain numerous simultaneously segregating polymorphisms subject to natural selection. Since selection acts on individuals whose fitness depends on many loci, different loci affect each other's dynamics. This leads to…

Populations and Evolution · Quantitative Biology 2011-08-09 Richard A. Neher , Boris I. Shraiman

This article deals with the emergence of a specific mating preference pattern called homogamy in a population. Individuals are characterized by their genotype at two haploid loci, and the population dynamics is modelled by a non-linear…

Probability · Mathematics 2019-09-25 Coron Camille , Costa Manon , Laroche Fabien , Leman Hélène , Smadi Charline

We study the population genetics of two neutral alleles under reversible mutation in the \Lambda-processes, a population model that features a skewed offspring distribution. We describe the shape of the equilibrium allele frequency…

Populations and Evolution · Quantitative Biology 2013-06-21 Ricky Der , Joshua B. Plotkin

In this paper we find and classify all patterns for a single locus three- and four-allele population genetics models in continuous time. A pattern for a $k$-allele model means all coexisting locally stable equilibria with respect to the…

Populations and Evolution · Quantitative Biology 2011-08-26 Linlin Su , Colbert Sesanker , Roger Lui

We model sex-structured population dynamics to analyze pairwise competition between groups differing both genetically and culturally. A sex-ratio allele is expressed in the heterogametic sex only, so that assumptions of Fisher's analysis do…

Populations and Evolution · Quantitative Biology 2012-09-10 F. Molnar , T. Caraco , G. Korniss