Related papers: Microtubule catastrophe from protofilament dynamic…
We use optical trapping to continuously bend an isolated microtubule while simultaneously measuring the applied force and the resulting filament strain, thus allowing us to determine its elastic properties over a wide range of applied…
A streamwise-constant model is presented to investigate the basic mechanisms responsible for the change in mean flow occuring during pipe flow transition. Using a single forced momentum balance equation, we show that the shape of the…
A theoretical model of stabilization of a microtubule assembly due to microtubule-associated-proteins(MAP) is presented. MAPs are assumed to bind to the microtubule filaments, thus preventing their disintegration following hydrolysis and…
Tipping points (TP) are abrupt transitions between metastable states in complex systems, most often described by a bifurcation or crisis of a multistable system induced by a slowly changing control parameter. An avenue for predicting TPs in…
Multi-phase materials are key for modern engineering applications. They are generally characterized by a high strength and ductility. Many of these materials fail by ductile fracture of the, generally softer, matrix phase. In this work we…
The subcritical transition to turbulence, as occurs in pipe flow, is believed to generically be a phase transition in the directed percolation universality class. At its heart is a balance between the decay rate and proliferation rate of…
Topological insulators (TIs) are newly discovered states of matter with robust metallic surface states protected by the topological properties of the bulk wavefunctions. A quantum phase transition (QPT) from a TI to a conventional insulator…
The tertiary instability is believed to be important for governing magnetised plasma turbulence under conditions of strong zonal flow generation, near marginal stability. In this work, we investigate its role for a collisionless strongly…
A re-investigation of the gravothermal catastrophe is presented. By means of a linear perturbation analysis, we study the dynamical stability of a spherical self-gravitating isothermal fluid of finite volume and find that the conditions for…
Fracture in aluminum alloys with precipitates involves at least two mechanisms, namely, ductile fracture of the aluminum-rich matrix and brittle fracture of the precipitates. In this work, a coupled crystal plasticity-phase field model for…
Model uncertainty and limited data are fundamental challenges to robust management of human intervention in a natural system. These challenges are acutely highlighted by concerns that many ecological systems may contain tipping points, such…
Starting from the hypothesis that the tubulin dimer is a conformationally bistable molecule - fluctuating between a curved and a straight configuration at room temperature - we develop a model for polymorphic dynamics of the microtubule…
Recent models of molecular cloud formation and evolution suggest that such clouds are dynamic and generally exhibit gravitational collapse. We present a simple analytic model of global collapse onto a filament and compare this with our…
The crucial initial step in planet formation is the agglomeration of micron-sized dust into macroscopic aggregates. This phase is likely to happen very early during the protostellar disc formation, which is characterised by active gas…
We present a coarse-grained two dimensional mechanical model for the microtubule-tau bundles in neuronal axons in which we remove taus, as can happen in various neurodegenerative conditions such as Alzheimer's disease, tauopathies, and…
Microtubules are filamentous tubular protein polymers which are essential for a range of cellular behaviour, and are generally straight over micron length scales. However, in some gliding assays, where microtubules move over a carpet of…
Our goal is to unravel the mechanisms that lead to failure of a ductile two-phase material - that consists of a ductile soft phase and a relatively brittle hard phase. An idealized microstructural model is used to study damage propagation…
The kinetics of droplet and bridge formation within striped nano-capillaries is studied when the wetting film grows via interface-limited growth. The phenomenological time-dependent Ginzburg-Landau (TDGL)-type model with thermal noise is…
Collective dynamics and force generation by cytoskeletal filaments are crucial in many cellular processes. Investigating growth dynamics of a bundle of N independent cytoskeletal filaments pushing against a wall, we show that chemical…
Many biological processes can be thought of as the result of an underlying dynamics in which the system repeatedly undergoes distinct and abortive trajectories with the dynamical process only ending when some specific process, purpose,…