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A ubiquitous building block of signaling pathways is a cycle of covalent modification (e.g., phosphorylation and dephosphorylation in MAPK cascades). Our paper explores the kind of information processing and filtering that can be…

Molecular Networks · Quantitative Biology 2015-05-13 Carlos Gomez-Uribe , George C. Verghese , Leonid A. Mirny

Many dynamical systems are subjected to stochastic influences, such as random excitations, noise, and unmodeled behavior. Tracking the system's state and parameters based on a physical model is a common task for which filtering algorithms,…

Signal Processing · Electrical Eng. & Systems 2024-07-03 Jan Grashorn , Matteo Broggi , Ludovic Chamoin , Michael Beer

Gaussian boson sampling is an important protocol for testing the performance of photonic quantum simulators. As such, various noise sources have been investigated that degrade the operation of such devices. In this paper, we examine a…

We examine the problem of time delay estimation, or temporal calibration, in the context of multisensor data fusion. Differences in processing intervals and other factors typically lead to a relative delay between measurement updates from…

Systems and Control · Electrical Eng. & Systems 2021-11-18 Jonathan Kelly , Christopher Grebe , Matthew Giamou

Whereas the importance of transient dynamics to the functionality and management of complex systems has been increasingly recognized, most of the studies are based on models. Yet in realistic situations the models are often unknown and what…

Adaptation and Self-Organizing Systems · Physics 2021-10-25 Huawei Fan , Liang Wang , Yao Du , Yafeng Wang , Jinghua Xiao , Xingang Wang

Molecular simulations and biophysical experiments can be used to provide independent and complementary insights into the molecular origin of biological processes. A particularly useful strategy is to use molecular simulations as a modelling…

Chemical Physics · Physics 2019-12-10 Simone Orioli , Andreas Haahr Larsen , Sandro Bottaro , Kresten Lindorff-Larsen

Data refinement is the standard extension of a refinement relation from programs to datatypes (i.e. a behavioural subtyping relation). Forward/backward simulations provide a tractable method for establishing data refinement, and have been…

Logic in Computer Science · Computer Science 2025-11-27 Chris Chen , Annabelle McIver , Carroll Morgan

This paper addresses the challenge of a particular class of noisy state observations in Markov Decision Processes (MDPs), a common issue in various real-world applications. We focus on modeling this uncertainty through a confusion matrix…

Machine Learning · Computer Science 2023-12-15 Amirhossein Afsharrad , Sanjay Lall

We revisit the development of grid based recursive approximate filtering of general Markov processes in discrete time, partially observed in conditionally Gaussian noise. The grid based filters considered rely on two types of state…

Statistics Theory · Mathematics 2016-08-24 Dionysios S. Kalogerias , Athina P. Petropulu

Transition State Theory overestimates reaction rates in solution because conventional dividing surfaces between reagents and products are crossed many times by the same reactive trajectory. We describe a recipe for constructing a…

Statistical Mechanics · Physics 2007-05-23 Thomas Bartsch , Rigoberto Hernandez , T. Uzer

Simulation especially real-time simulation have been widely used for the design and testing of real-time systems. The advancement of simulation tools has largely attributed to the evolution of computing technologies. With the reduced cost…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-07 Xi Zheng

Accurate estimation of the dynamic states of a synchronous machine (e.g., rotor s angle and speed) is essential in monitoring and controlling transient stability of a power system. It is well known that the covariance matrixes of process…

Systems and Control · Computer Science 2017-02-06 Shahrokh Akhlaghi , Ning Zhou , Zhenyu Huang

When designing systems that are complex, dynamic and stochastic in nature, simulation is generally recognised as one of the best design support technologies, and a valuable aid in the strategic and tactical decision making process. A…

Neural and Evolutionary Computing · Computer Science 2013-05-30 Peer-Olaf Siebers , Uwe Aickelin

Filtered shot noise processes have proven to be very effective in modelling the evolution of systems exposed to stochastic shot noise sources, and have been applied to a wide variety of fields ranging from electronics through biology. In…

Neurons and Cognition · Quantitative Biology 2015-09-15 Marco Brigham , Alain Destexhe

State-space models can be used to incorporate subject knowledge on the underlying dynamics of a time series by the introduction of a latent Markov state-process. A user can specify the dynamics of this process together with how the state…

Computation · Statistics 2017-09-14 Paul Fearnhead , Hans Künsch

Differences between computer simulation of dynamical systems and laboratory experiments are common in teaching and research in engineering. Normally, numerical inaccuracy and the non-ideal behaviour of the devices involved in the experiment…

Numerical Analysis · Mathematics 2016-12-14 M. L. C. Peixoto , E. G. Nepomuceno , H. M. Rodrigues , S. A. M. Martins , G. F. V. Amaral

Benchmarking is how the performance of a computing system is determined. Surprisingly, even for classical computers this is not a straightforward process. One must choose the appropriate benchmark and metrics to extract meaningful results.…

Quantum Physics · Physics 2021-05-07 Salonik Resch , Ulya R. Karpuzcu

Stochastic transitions between discrete microscopic states play an important role in many physical and biological systems. Often, these transitions lead to fluctuations on a macroscopic scale. A classic example from neuroscience is the…

Statistical Mechanics · Physics 2024-02-20 Lukas Ramlow , Benjamin Lindner

We investigate the simulation problem in of dense-time system. A specification simulates a model if the specification can match every transition that the model can make at a time point. We also adapt the approach of Emerson and Lei and…

Logic in Computer Science · Computer Science 2010-07-06 Farn Wang

The unknown inputs in a dynamical system may represent unknown external drivers, input uncertainty, state uncertainty, or instrument faults and thus unknown-input reconstruction has several wide-spread applications. In this paper we…

Optimization and Control · Mathematics 2015-09-22 Roshan A Chavan , Harish J. Palanthandalam-Madapusi