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The coupled Wright-Fisher diffusion is a multi-dimensional Wright-Fisher diffusion for multi-locus and multi-allelic genetic frequencies, expressed as the strong solution to a system of stochastic differential equations that are coupled in…

Probability · Mathematics 2025-03-17 Martina Favero , Henrik Hult , Timo Koski

We study a universal object for the genealogy of a sample in populations with mutations: the critical birth-death process with Poissonian mutations, conditioned on its population size at a fixed time horizon. We show how this process arises…

Probability · Mathematics 2014-07-30 G. Achaz , C. Delaporte , A. Lambert

Given an evolutionary model, such as Wright--Fisher (WF) or Moran, the n-coalescent problem consists of going backward in time to find for example the time to the most recent common ancestor (MRCA) and the topology of the tree. In the…

Populations and Evolution · Quantitative Biology 2025-11-14 Bahram Houchmandzadeh

Recruitment dynamics, or the distribution of the number of offspring among individuals, is central for understanding ecology and evolution. Sweepstakes reproduction (heavy right-tailed offspring number distribution) is central for…

Populations and Evolution · Quantitative Biology 2026-01-16 Bjarki Eldon

The goal of this paper is to prove rigorous results for the behavior of genealogies in a one-dimensional long range biased voter model introduced by Hallatschek and Nelson [25]. The first step, which is easily accomplished using results of…

Probability · Mathematics 2021-01-12 Rick Durrett , Wai-Tong Louis Fan

Compared to a neutral model, purifying selection distorts the structure of genealogies and hence alters the patterns of sampled genetic variation. Although these distortions may be common in nature, our understanding of how we expect…

Populations and Evolution · Quantitative Biology 2011-05-30 Aleksandra M. Walczak , Lauren E. Nicolaisen , Joshua B. Plotkin , Michael M. Desai

The rapid development of sequencing technologies represents new opportunities for population genetics research. It is expected that genomic data will increase our ability to reconstruct the history of populations. While this increase in…

Populations and Evolution · Quantitative Biology 2014-12-04 Olivier Mazet , Willy Rodríguez , Lounès Chikhi

Coalescence processes have received a lot of attention in the context of conditional branching processes with fixed population size and non-overlapping generations. Here we focus on similar problems in the context of the standard…

Probability · Mathematics 2017-09-25 Nicolas Grosjean , Thierry Huillet

Mathematical models of genetic evolution often come in pairs, connected by a so-called duality relation. The most seminal example are the Wright-Fisher diffusion and the Kingman coalescent, where the former describes the stochastic…

Probability · Mathematics 2024-02-02 Jere Koskela , Krzysztof Łatuszyński , Dario Spanò

We investigate the genealogy of a sample of $k\geq1$ particles chosen uniformly without replacement from a population alive at large times in a critical discrete-time Galton-Watson process in a varying environment (GWVE). We will show that…

Probability · Mathematics 2024-03-04 Simon C. Harris , Sandra Palau , Juan Carlos Pardo

Collaborative Filtering (CF) is widely used in recommender systems to model user-item interactions. With the great success of Deep Neural Networks (DNNs) in various fields, advanced works recently have proposed several DNN-based models for…

Neural and Evolutionary Computing · Computer Science 2021-11-16 Yuhan Fang , Yuqiao Liu , Yanan Sun

The observed sequence variation at a locus informs about the evolutionary history of the sample and past population size dynamics. The Kingman coalescent is used in a generative model of molecular sequence variation to infer evolutionary…

Methodology · Statistics 2021-06-22 Lorenzo Cappello , Amandine Veber , Julia A. Palacios

Demographic models built from genetic data play important roles in illuminating prehistorical events and serving as null models in genome scans for selection. We introduce an inference method based on the joint frequency spectrum of genetic…

Populations and Evolution · Quantitative Biology 2010-05-10 Ryan N. Gutenkunst , Ryan D. Hernandez , Scott H. Williamson , Carlos D. Bustamante

The increasing availability of population-level allele frequency data across one or more related populations necessitates the development of methods that can efficiently estimate population genetics parameters, such as the strength of…

Computation · Statistics 2017-11-09 Jeffrey J. Gory , Radu Herbei , Laura S. Kubatko

A number of discrete time, finite population size models in genetics describing the dynamics of allele frequencies are known to converge (subject to suitable scaling) to a diffusion process in the infinite population limit, termed the…

Probability · Mathematics 2021-09-14 Jaromir Sant , Paul A. Jenkins , Jere Koskela , Dario Spano

The sample frequency spectrum of a segregating site is the probability distribution of a sample of alleles from a genetic locus, conditional on observing the sample to have more than one clearly different phenotypes. We present a model for…

Probability · Mathematics 2014-05-13 Arka Bhattacharya

Characterizing time-evolution of allele frequencies in a population is a fundamental problem in population genetics. In the Wright-Fisher diffusion, such dynamics is captured by the transition density function, which satisfies well-known…

Probability · Mathematics 2013-08-06 Matthias Steinrücken , Y. X. Rachel Wang , Yun S. Song

We study a population model of fixed size undergoing strong selection where individuals accumulate beneficial mutations, namely the Moran model with selection. In a specific setting with strong selection, Schweinsberg showed that the…

Probability · Mathematics 2021-03-31 François Gaston Ged

It is becoming routine to obtain datasets on DNA sequence variation across several thousands of chromosomes, providing unprecedented opportunity to infer the underlying biological and demographic forces. Such data make it vital to study…

Populations and Evolution · Quantitative Biology 2015-06-24 Paul A. Jenkins , Jonas W. Mueller , Yun S. Song

Take a continuous-time Galton-Watson tree. If the system survives until a large time $T$, then choose $k$ particles uniformly from those alive. What does the ancestral tree drawn out by these $k$ particles look like? Some special cases are…

Probability · Mathematics 2019-02-14 Simon C. Harris , Samuel G. G. Johnston , Matthew I. Roberts