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We investigate the ability of algorithms developed for reverse engineering of transcriptional regulatory networks to reconstruct metabolic networks from high-throughput metabolite profiling data. For this, we generate synthetic metabolic…

Molecular Networks · Quantitative Biology 2007-11-19 Ilya Nemenman , G. Sean Escola , William S. Hlavacek , Pat J. Unkefer , Clifford J. Unkefer , Michael E. Wall

Event cameras are novel vision sensors that sample, in an asynchronous fashion, brightness increments with low latency and high temporal resolution. The resulting streams of events are of high value by themselves, especially for high speed…

Computer Vision and Pattern Recognition · Computer Science 2021-04-13 F. Paredes-Vallés , G. C. H. E. de Croon

Inferring the exact parameters of a neural network with only query access is an NP-Hard problem, with few practical existing algorithms. Solutions would have major implications for security, verification, interpretability, and understanding…

Machine Learning · Computer Science 2024-10-01 Judah Goldfeder , Quinten Roets , Gabe Guo , John Wright , Hod Lipson

Network reconstruction is the task of inferring the unseen interactions between elements of a system, based only on their behavior or dynamics. This inverse problem is in general ill-posed, and admits many solutions for the same…

Machine Learning · Statistics 2025-03-12 Tiago P. Peixoto

Deep learning-based computational methods have achieved promising results in predicting protein-protein interactions (PPIs). However, existing benchmarks predominantly focus on isolated pairwise evaluations, overlooking a model's capability…

Machine Learning · Computer Science 2025-10-23 Xinzhe Zheng , Hao Du , Fanding Xu , Jinzhe Li , Zhiyuan Liu , Wenkang Wang , Tao Chen , Wanli Ouyang , Stan Z. Li , Yan Lu , Nanqing Dong , Yang Zhang

Reconstructing complex networks from measurable data is a fundamental problem for understanding and controlling collective dynamics of complex networked systems. However, a significant challenge arises when we attempt to decode structural…

Physics and Society · Physics 2015-11-20 Xiao Han , Zhesi Shen , Wen-Xu Wang , Zengru Di

Graphical models are useful tools for describing structured high-dimensional probability distributions. Development of efficient algorithms for learning graphical models with least amount of data remains an active research topic.…

Machine Learning · Computer Science 2021-11-18 Marc Vuffray , Sidhant Misra , Andrey Y. Lokhov

Recent crises have shown that the knowledge of the structure of input-output networks at the firm level is crucial when studying economic resilience from the microscopic point of view of firms that rewire their connections under supply and…

Despite the remarkable success of deep learning systems over the last decade, a key difference still remains between neural network and human decision-making: As humans, we cannot only form a decision on the spot, but also ponder,…

Computer Vision and Pattern Recognition · Computer Science 2023-09-15 Gregor Koehler , Tassilo Wald , Constantin Ulrich , David Zimmerer , Paul F. Jaeger , Jörg K. H. Franke , Simon Kohl , Fabian Isensee , Klaus H. Maier-Hein

In this work we present a system based on a Deep Learning approach, by using a Convolutional Neural Network, capable of classifying protein chains of amino acids based on the protein description contained in the Protein Data Bank. Each…

Machine Learning · Computer Science 2021-11-04 Damiano Perri , Marco Simonetti , Andrea Lombardi , Noelia Faginas-Lago , Osvaldo Gervasi

It is a significant challenge to predict the network topology from a small amount of dynamical observations. Different from the usual framework of the node-based reconstruction, two optimization approaches (i.e., the global and partitioned…

Physics and Society · Physics 2016-03-03 Ming Xu , Chuan-Yun Xu , Huan Wang , Yong-Kui Li , Jing-Bo Hu , Ke-Fei Cao

It is common for people to access multiple social networks, for example, using phone, email, and social media. Together, the multi-layer social interactions form a "integrated social network." How can we extend well developed knowledge…

Social and Information Networks · Computer Science 2016-09-07 Kristina Lerman , Shang-Hua Teng , Xiaoran Yan

Multi-condition information retrieval (IR) presents a significant, yet underexplored challenge for existing systems. This paper introduces MultiConIR, a benchmark specifically designed to evaluate retrieval and reranking models under…

Information Retrieval · Computer Science 2025-09-05 Xuan Lu , Sifan Liu , Bochao Yin , Yongqi Li , Xinghao Chen , Hui Su , Yaohui Jin , Wenjun Zeng , Xiaoyu Shen

Recent advancements in machine learning techniques for protein folding motivate better results in its inverse problem -- protein design. In this work we introduce a new graph mimetic neural network, MimNet, and show that it is possible to…

Biomolecules · Quantitative Biology 2021-02-09 Moshe Eliasof , Tue Boesen , Eldad Haber , Chen Keasar , Eran Treister

Training data reconstruction from KKT conditions has shown striking empirical success, yet it remains unclear when the resulting KKT equations have unique solutions and, even in identifiable regimes, how to reliably recover solutions by…

Machine Learning · Computer Science 2026-02-10 Yujie Shen , Zihan Wang , Jian Qian , Qi Lei

Identifying key influencers from time series data without a known prior network structure is a challenging problem in various applications, from crime analysis to social media. While much work has focused on event-based time series…

Dynamical Systems · Mathematics 2025-04-30 Naratip Santitissadeekorn , Martin Short , David J. B. Lloyd

Graphical models are widely used to study complex multivariate biological systems. Network inference algorithms aim to reverse-engineer such models from noisy experimental data. It is common to assess such algorithms using techniques from…

Methodology · Statistics 2014-03-03 Chris J. Oates , Richard Amos , Simon E. F. Spencer

When studying social, economic and biological systems, one has often access to only limited information about the structure of the underlying networks. An example of paramount importance is provided by financial systems: information on the…

Physics and Society · Physics 2018-10-31 Tiziano Squartini , Guido Caldarelli , Giulio Cimini , Andrea Gabrielli , Diego Garlaschelli

The well-known issue of reconstructing regulatory networks from gene expression measurements has been somewhat disrupted by the emergence and rapid development of single-cell data. Indeed, the traditional way of seeing a gene regulatory…

Molecular Networks · Quantitative Biology 2021-10-01 Ulysse Herbach

When studying multi-body protein complexes, biochemists use computational tools that can suggest hundreds or thousands of their possible spatial configurations. However, it is not feasible to experimentally verify more than only a very…

Human-Computer Interaction · Computer Science 2019-09-25 Katarína Furmanová , Adam Jurčík , Barbora Kozlíková , Helwig Hauser , Jan Byška
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