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The characterization of network and biophysical properties from neural spiking activity is an important goal in neuroscience. A framework that provides unbiased inference on causal synaptic interaction and single neural properties has been…

Neurons and Cognition · Quantitative Biology 2024-05-27 Kevin S. Chen , Ying-Jen Yang

Simulating dynamic rupture propagation is challenging due to the uncertainties involved in the underlying physics of fault slip, stress conditions, and frictional properties of the fault. A trial and error approach is often used to…

Geophysics · Physics 2019-06-17 Sabber Ahamed , Eric G. Daub

Extreme events such as earthquakes, floods, and power blackouts often display burst phenomena where multiple extreme events occur in quick succession or in bunches. This study examines bunching of extreme events on a complex network using a…

Physics and Society · Physics 2025-09-24 Sarvesh K. Upadhyay , Vimal Kishore , Sanjay Kumar , R. E. Amritkar

Consider a multi-dimensional supercritical branching process with offspring distribution in a parametric family. Here, each vector coordinate corresponds to the number of offspring of a given type. The process is observed under family-size…

Statistics Theory · Mathematics 2025-06-13 Gonzalo Contador , Bret Hanlon

In this paper, we propose a novel Branching Reinforcement Learning (Branching RL) model, and investigate both Regret Minimization (RM) and Reward-Free Exploration (RFE) metrics for this model. Unlike standard RL where the trajectory of each…

Machine Learning · Computer Science 2022-06-16 Yihan Du , Wei Chen

We study time continuous branching processes with exponentially distributed lifetimes, with two types of cells that proliferate according to binary fission. A range of possible system dynamics are considered, each of which is characterized…

Probability · Mathematics 2022-04-27 Nam H Nguyen , Marek Kimmel

The use of machine learning algorithms is an attractive way to produce very fast detector simulations for scattering reactions that can otherwise be computationally expensive. Here we develop a factorised approach where we deal with each…

Data Analysis, Statistics and Probability · Physics 2022-07-26 D. Darulis , R. Tyson , D. G. Ireland , D. I. Glazier , B. McKinnon , P. Pauli

Multiple dynamic pathways always exist in biological networks, but their robustness against internal fluctuations and relative stability have not been well recognized and carefully analyzed yet. Here we try to address these issues through…

Molecular Networks · Quantitative Biology 2015-11-27 Yongyi Guo , Zhiyi You , Min Qian , Hao Ge

We present exact results for the degree distribution in a directed network model that grows by node duplication (ND). Such models are useful in the study of the structure and growth dynamics of gene regulatory networks and scientific…

Physics and Society · Physics 2019-08-21 Chanania Steinbock , Ofer Biham , Eytan Katzav

We extend in two directions our previous results about the sampling and the empirical measures of immortal branching Markov processes. Direct applications to molecular biology are rigorous estimates of the mutation rates of polymerase chain…

Probability · Mathematics 2007-05-23 Didier Piau

The recent development of single-cell transcriptomics has enabled gene expression to be measured in individual cells instead of being population-averaged. Despite this considerable precision improvement, inferring regulatory networks…

Molecular Networks · Quantitative Biology 2017-11-28 Ulysse Herbach , Arnaud Bonnaffoux , Thibault Espinasse , Olivier Gandrillon

Optimal designs minimize the number of experimental runs (samples) needed to accurately estimate model parameters, resulting in algorithms that, for instance, efficiently minimize parameter estimate variance. Governed by knowledge of past…

Methodology · Statistics 2023-02-03 Nicholas W. Barendregt , Emily G. Webb , Zachary P. Kilpatrick

We study model-based reinforcement learning (RL) for episodic Markov decision processes (MDP) whose transition probability is parametrized by an unknown transition core with features of state and action. Despite much recent progress in…

Machine Learning · Statistics 2024-11-19 Taehyun Hwang , Min-hwan Oh

The controlled branching process is a generalization of the classical Bienaym\'e-Galton-Watson branching process. It is a useful model for describing the evolution of populations in which the population size at each generation needs to be…

Statistics Theory · Mathematics 2015-02-09 M. Gonzalez , C. Minuesa , I. del Puerto

Continuous-time branching processes (CTBPs) are powerful tools in random graph theory, but are not appropriate to describe real-world networks, since they produce trees rather than (multi)graphs. In this paper we analyze collapsed branching…

Probability · Mathematics 2017-11-10 Alessandro Garavaglia , Remco van der Hofstad

In this work, we consider the problem of estimating summary statistics to characterise biochemical reaction networks of interest. Such networks are often described using the framework of the Chemical Master Equation (CME). For…

Quantitative Methods · Quantitative Biology 2018-11-27 Christopher Lester , Christian A. Yates , Ruth E. Baker

We consider catalytic branching populations. They consist of a catalyst population evolving according to a critical binary branching process in continuous time with a constant branching rate and a reactant population with a branching rate…

Probability · Mathematics 2009-09-29 Andreas Greven , Lea Popovic , Anita Winter

We present a new approach to assessing the robustness of neural networks based on estimating the proportion of inputs for which a property is violated. Specifically, we estimate the probability of the event that the property is violated…

Machine Learning · Statistics 2019-02-25 Stefan Webb , Tom Rainforth , Yee Whye Teh , M. Pawan Kumar

We propose a novel approach for inferring the individualized causal effects of a treatment (intervention) from observational data. Our approach conceptualizes causal inference as a multitask learning problem; we model a subject's potential…

Machine Learning · Computer Science 2017-06-20 Ahmed M. Alaa , Michael Weisz , Mihaela van der Schaar

Survival analysis studies and predicts the time of death, or other singular unrepeated events, based on historical data, while the true time of death for some instances is unknown. Survival trees enable the discovery of complex nonlinear…

Machine Learning · Computer Science 2024-01-10 Tim Huisman , Jacobus G. M. van der Linden , Emir Demirović