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Graphical models are useful tools for describing structured high-dimensional probability distributions. Development of efficient algorithms for learning graphical models with least amount of data remains an active research topic.…

Machine Learning · Computer Science 2021-11-18 Marc Vuffray , Sidhant Misra , Andrey Y. Lokhov

The quality of numerical reconstructions for unknown parameters in inverse problems depends fundamentally on the selection of experimental data. To ensure a robust reconstruction, it is crucial to select data that are sensitive to the…

Numerical Analysis · Mathematics 2026-04-14 Kathrin Hellmuth , Christian Klingenberg , Qin Li

Pattern formation in biological tissues plays an important role in the development of living organisms. Since the classical work of Alan Turing, a pre-eminent way of modelling has been through reaction-diffusion mechanisms. More recently,…

Analysis of PDEs · Mathematics 2023-01-27 Alexey Kazarnikov , Robert Scheichl , Heikki Haario , Anna Marciniak-Czochra

Ordinary differential equation models are nowadays widely used for the mechanistic description of biological processes and their temporal evolution. These models typically have many unknown and non-measurable parameters, which have to be…

Quantitative Methods · Quantitative Biology 2021-05-27 Alejandro F. Villaverde , Dilan Pathirana , Fabian Fröhlich , Jan Hasenauer , Julio R. Banga

If model identifiability is not confirmed, inferences from infectious disease transmission models may not be reliable, so they might lead to misleading recommendations. Structural identifiability analysis characterizes whether it is…

Quantitative Methods · Quantitative Biology 2022-06-09 Emmanuelle A. Dankwa , Andrew F. Brouwer , Christl A. Donnelly

Many models in mathematical epidemiology are developed with the aim to provide a framework for parameter estimation and then prediction. It is well-known that parameters are not always uniquely identifiable. In this paper we consider…

Dynamical Systems · Mathematics 2022-08-17 István Zoltán Kiss , Péter L. Simon

The use of Hodgkin-Huxley (HH) equations abounds in the literature, but the identifiability of the HH model parameters has not been broadly considered. Identifiability analysis addresses the question of whether it is possible to estimate…

Neurons and Cognition · Quantitative Biology 2015-11-18 Olivia J. Walch , Marisa C. Eisenberg

Dynamical systems, for instance in model predictive control, often contain unknown parameters, which must be determined during system operation. Online or on-the-fly parameter identification methods are therefore necessary. The challenge of…

Optimization and Control · Mathematics 2021-04-05 Barbara Kaltenbacher , Tram Thi Ngoc Nguyen

Mixtures of regression are a powerful class of models for regression learning with respect to a highly uncertain and heterogeneous response variable of interest. In addition to being a rich predictive model for the response given some…

Statistics Theory · Mathematics 2024-01-30 Dat Do , Linh Do , XuanLong Nguyen

The efforts associated with parametrization of continuum-based models for crystal plasticity are a significant obstacle for the routine use of these models in materials science and engineering. While phenomenological constitutive…

Materials Science · Physics 2025-02-18 Nikhil Prabhu , Martin Diehl

This paper develops a smooth model identification and self-learning strategy for dynamic systems taking into account possible parameter variations and uncertainties. We have tried to solve the problem such that the model follows the changes…

Systems and Control · Electrical Eng. & Systems 2025-01-07 Ebrahim Navid Sadjadi , Jesus Garcia , Jose M. Molina , Akbar Hashemi Borzabadi , Monireh Asadi Abchouyeh

This paper proposes a probabilistic Bayesian formulation for system identification (ID) and estimation of nonseparable Hamiltonian systems using stochastic dynamic models. Nonseparable Hamiltonian systems arise in models from diverse…

Dynamical Systems · Mathematics 2022-09-19 Harsh Sharma , Nicholas Galioto , Alex A. Gorodetsky , Boris Kramer

This paper studies the identification of nonlinearly parameterized control systems in given experiments. Several identifiability criteria are established and an implementable algorithm is proposed for practicality with the convergence rate…

Optimization and Control · Mathematics 2019-08-21 Chanying Li

Model identification is a crucial problem in chemical industries. In recent years, there has been increasing interest in learning data-driven models utilizing partial knowledge about the system of interest. Most techniques for model…

Machine Learning · Computer Science 2020-07-09 Deepak Maurya , Sivadurgaprasad Chinta , Abhishek Sivaram , Raghunathan Rengaswamy

A data analysis pipeline is a structured sequence of steps that transforms raw data into meaningful insights by integrating various analysis algorithms. In this paper, we propose a novel statistical test to assess the significance of data…

Machine Learning · Statistics 2024-10-15 Tomohiro Shiraishi , Tatsuya Matsukawa , Shuichi Nishino , Ichiro Takeuchi

We study the robustness of system estimation to parametric perturbations in system dynamics and initial conditions. We define the problem of sensitivity-based parametric uncertainty quantification in dynamical system estimation. The main…

Systems and Control · Electrical Eng. & Systems 2025-09-09 Ayush Pandey

The mitotic cell cycle governs DNA replication and cell division. The effectiveness of radiotherapy and chemotherapy depends on cell-cycle position, with increased resistance during DNA replication and mitosis. Thus, accurate mathematical…

Cell Behavior · Quantitative Biology 2026-03-10 Ruby E. Nixson , Helen M. Byrne , Joe M. Pitt-Francis , Philip K. Maini

When a mathematical or computational model is used to analyse some system, it is usual that some parameters resp.\ functions or fields in the model are not known, and hence uncertain. These parametric quantities are then identified by…

Probability · Mathematics 2016-07-01 Hermann G. Matthies , Elmar Zander , Bojana Rosic , Alexander Litvinenko

Many recent works have reconstructed distinctive 3D face shapes by aggregating shape parameters of the same identity and separating those of different people based on parametric models (e.g., 3D morphable models (3DMMs)). However, despite…

Computer Vision and Pattern Recognition · Computer Science 2021-12-28 Diqiong Jiang , Yiwei Jin , Fanglue Zhang , Yukun Yai , Risheng Deng , Ruofeng Tong , Min Tang

Mathematical modelling has become an established tool for studying the dynamics of biological systems. Current applications range from building models that reproduce quantitative data to identifying systems with predefined qualitative…

Molecular Networks · Quantitative Biology 2018-02-07 Carsten Conradi , Elisenda Feliu , Maya Mincheva , Carsten Wiuf
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