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Application of computation in many fields are growing fast in last two decades. Increasing on computation performance helps researchers to understand natural phenomena in many fields of science and technology including in life sciences.…

Biological Physics · Physics 2014-02-27 Suprijadi , Mohamad Rendi , Petrus Subekti , Sparisoma Viridi

Human blood flow is a multi-scale problem: in first approximation, blood is a dense suspension of plasma and deformable red cells. Physiological vessel diameters range from about one to thousands of cell radii. Current computational models…

Soft Condensed Matter · Physics 2015-03-17 Florian Janoschek , Federico Toschi , Jens Harting

The multi-cellular hydrodynamic interactions play a critical role in the phenomenology of blood flow in the microcirculation. A fast algorithm has been developed to simulate large numbers of cells modeled as elastic thin membranes. For red…

Fluid Dynamics · Physics 2008-10-14 Amir H. G. Isfahani , Hong Zhao , Jonathan B. Freund

Understanding the physics of blood is challenging due to its nature as a suspension of soft particles and the fact that typical problems involve different scales. This is valid also for numerical investigations. In fact, many computational…

Soft Condensed Matter · Physics 2011-09-16 Florian Janoschek , Federico Toschi , Jens Harting

The blood vascular system consists of blood vessels such as arteries, arterioles, capillaries and veins that convey blood throughout the body. The pressure difference which exists between the ends of the vessels provides the living force…

Tissues and Organs · Quantitative Biology 2020-04-21 Tahmineh Azizi , Robert Mugabi

Molecular dynamics has been widely used to numerically solve equation of motion of classical many-particle system. It can be used to simulate many systems including biophysics, whose complexity level is determined by the involved elements.…

Biological Physics · Physics 2014-02-27 Luman Haris , Siti Nurul Khotimah , Freddy Haryanto , Sparisoma Viridi

Red blood cells (RBCs) are an essential component of blood. A method to include the particulate nature of blood is introduced here with the goal of studying circulation in large-scale realistic vessels. The method uses a combination of the…

Medical Physics · Physics 2011-07-26 Simone Melchionna

Mathematical models and numerical simulations are widely used in the field of hemodynamics, representing a valuable resource to better understand physiological and pathological processes. The theory behind the phenomenon is closely related…

Fluid Dynamics · Physics 2021-06-15 Giulia Bertaglia , Valerio Caleffi , Alessandro Valiani

We present a two dimensional model describing the elastic behaviour of the wall of a curved blood vessel. The wall has a laminate structure consisting of several anisotropic layers of varying thickness and is assumed to be much smaller in…

Tissues and Organs · Quantitative Biology 2017-08-18 Arpan Ghosh , Vladimir Kozlov , Sergey Nazarov , David Rule

We performed numerical simulations of blood flow in arteries with a variable stiffness and cross-section at rest using a finite volume method coupled with a hydrostatic reconstruction of the variables at the interface of each mesh cell. The…

Numerical Analysis · Mathematics 2015-09-15 Olivier Delestre , Arthur Ghigo , Jose-Maria Fullana , Pierre-Yves Lagrée

Non-particulate continuum descriptions allow for computationally efficient modeling of suspension flows at scales that are inaccessible to more detailed particulate approaches. It is well known that the presence of particles influences the…

Soft Condensed Matter · Physics 2013-11-13 Florian Janoschek , Jens Harting , Federico Toschi

Computational modelling is helpful for elucidating the cellular mechanisms driving biological morphogenesis. Previous simulation studies of blood vessel growth based on the Cellular Potts model (CPM) proposed that elongated, adhesive or…

Cell Behavior · Quantitative Biology 2015-09-07 Dimitrios Palachanis , András Szabó , Roeland M. H. Merks

The aim of this paper is to propose a new numerical model to simulate 2D vesicles interacting with a newtonian fluid. The inextensible membrane is modeled by a chain of circular rigid particles which are maintained in cohesion by using two…

Mathematical Physics · Physics 2012-02-15 Mourad Ismail , Aline Lefebvre-Lepot

We consider a multiscale approach based on immersed methods for the efficient computational modeling of tissues composed of an elastic matrix (in two or three-dimensions) and a thin vascular structure (treated as a co-dimension two…

Numerical Analysis · Mathematics 2021-11-18 Luca Heltai , Alfonso Caiazzo

Fast and realistic coupling of blood flow and vessel wall is of great importance to virtual surgery. In this paper, we propose a novel data-driven coupling method that formulates physics-based blood flow simulation as a regression problem,…

Graphics · Computer Science 2019-01-25 Xuejie Mai , Zhiyong Yuan , Qianqian Tong , Tianchen Yuan , Jianhui Zhao

When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering…

Tissues and Organs · Quantitative Biology 2015-06-18 Ziheng Wu , Zhiliang Xu , Oleg Kim , Mark Alber

Microvessels -blood vessels with diameter less than 200 microns- form large, intricate networks organized into arterioles, capillaries and venules. In these networks, the distribution of flow and pressure drop is a highly interlaced…

Tissues and Organs · Quantitative Biology 2017-08-02 Paola Causin , Francesca Malgaroli

Fluid flow simulation is a highly active area with applications in a wide range of engineering problems and interactive systems. Meshless methods like the Moving Particle Semi-implicit (MPS) are a great alternative to deal efficiently with…

In vascular targeted therapies, blood-borne carriers should realize sustained drug release from the luminal side towards the diseased tissue. In this context, such carriers are required to firmly adhere to the vessel walls for a sufficient…

Fluid Dynamics · Physics 2022-10-13 A. Coclite , G. Pascazio , M. D. de Tullio , P. Decuzzi

This paper worked towards modeling blood platelets. Blood platelets, also known as thrombocytes, play a key role in blood clotting which is a vital human function. Furthermore, the role of these entities in strokes, myocardial infarctions,…

Cell Behavior · Quantitative Biology 2012-06-05 Vijay Viswanathan , Seetha Pothapragada
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