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This Thesis presents research at the boundary between Statistical Physics and Biology. First, we have devised a class of Boolean constraint satisfaction problems (CSP) whose solutions describe the feasible operational states of a chemical…

Molecular Networks · Quantitative Biology 2019-08-15 Alessandro Seganti

We analyze the solutions, on single network instances, of a recently introduced class of constraint-satisfaction problems (CSPs), describing feasible steady states of chemical reaction networks. First, we show that the CSPs generalize the…

Molecular Networks · Quantitative Biology 2014-03-05 Alessandro Seganti , Federico Ricci-Tersenghi , Andrea De Martino

Boolean networks model finite discrete dynamical systems with complex behaviours. The state of each component is determined by a Boolean function of the state of (a subset of) the components of the network. This paper addresses the…

Artificial Intelligence · Computer Science 2020-02-28 Stéphanie Chevalier , Christine Froidevaux , Loïc Paulevé , Andrei Zinovyev

A new field of research is rapidly expanding at the crossroad between statistical physics, information theory and combinatorial optimization. In particular, the use of cutting edge statistical physics concepts and methods allow one to solve…

Neurons and Cognition · Quantitative Biology 2008-03-28 Marc Mezard , Thierry Mora

LECTURE GIVEN AT TH2002. Given a set of Boolean variables, and some constraints between them, is it possible to find a configuration of the variables which satisfies all constraints? This problem, which is at the heart of combinatorial…

Disordered Systems and Neural Networks · Physics 2009-11-07 Marc Mezard

Random instances of constraint satisfaction problems such as k-SAT provide challenging benchmarks. If there are m constraints over n variables there is typically a large range of densities r=m/n where solutions are known to exist with…

Discrete Mathematics · Computer Science 2009-11-13 Amin Coja-Oghlan

Random constraint satisfaction problems play an important role in computer science and combinatorics. For example, they provide challenging benchmark instances for algorithms and they have been harnessed in probabilistic constructions of…

Combinatorics · Mathematics 2020-05-27 Amin Coja-Oghlan , Tobias Kapetanopoulos , Noela Müller

Two contrasting algorithmic paradigms for constraint satisfaction problems are successive local explorations of neighboring configurations versus producing new configurations using global information about the problem (e.g. approximating…

Quantum Physics · Physics 2022-12-09 S. Andrew Lanham

We develop the theory and practice of an approach to modelling and probabilistic inference in causal networks that is suitable when application-specific or analysis-specific constraints should inform such inference or when little or no data…

Artificial Intelligence · Computer Science 2017-05-16 Paul Beaumont , Michael Huth

We propose to leverage epistemic uncertainty about constraint satisfaction of a reinforcement learner in safety critical domains. We introduce a framework for specification of requirements for reinforcement learners in constrained settings,…

Artificial Intelligence · Computer Science 2021-02-09 Lenz Belzner , Martin Wirsing

Characterization of the differences between biological and random networks can reveal the design principles that enable the robust realization of crucial biological functions including the establishment of different cell types. Previous…

Molecular Networks · Quantitative Biology 2020-08-26 Shubham Tripathi , David A. Kessler , Herbert Levine

Compared with constraint satisfaction problems, counting problems have received less attention. In this paper, we survey research works on the problems of counting the number of solutions to constraints. The constraints may take various…

Artificial Intelligence · Computer Science 2020-12-29 Jian Zhang , Cunjing Ge , Feifei Ma

This paper explores algorithms for processing probabilistic and deterministic information when the former is represented as a belief network and the latter as a set of boolean clauses. The motivating tasks are 1. evaluating beliefs networks…

Artificial Intelligence · Computer Science 2013-01-14 Rina Dechter , David Ephraim Larkin

Many AI synthesis problems such as planning or scheduling may be modelized as constraint satisfaction problems (CSP). A CSP is typically defined as the problem of finding any consistent labeling for a fixed set of variables satisfying all…

Artificial Intelligence · Computer Science 2013-03-25 Thomas Schiex

Autocatalytic chemical networks play a predominant role in a large number of natural systems such as in metabolic pathways and in ecological networks. Despite recent efforts, the precise impact of thermodynamic constraints on these networks…

Chemical Physics · Physics 2024-06-14 Armand Despons , Yannick de Decker , David Lacoste

We study constraint satisfaction problems on the so-called 'planted' random ensemble. We show that for a certain class of problems, e.g. graph coloring, many of the properties of the usual random ensemble are quantitatively identical in the…

Statistical Mechanics · Physics 2009-06-13 Florent Krzakala , Lenka Zdeborová

Biological processes, including cell differentiation, organism development, and disease progression, can be interpreted as attractors (fixed points or limit cycles) of an underlying networked dynamical system. In this paper, we study the…

Systems and Control · Computer Science 2017-01-20 Andrew Clark , Phillip Lee , Basel Alomair , Linda Bushnell , Radha Poovendran

The determination and classification of fixed points of large Boolean networks is addressed in terms of constraint satisfaction problem. We develop a general simplification scheme that, removing all those variables and functions belonging…

Disordered Systems and Neural Networks · Physics 2009-11-10 L. Correale , M. Leone , A. Pagnani , M. Weigt , R. Zecchina

An active topic in the study of random constraint satisfaction problems (CSPs) is the geometry of the space of satisfying or almost satisfying assignments as the function of the density, for which a precise landscape of predictions has been…

Data Structures and Algorithms · Computer Science 2021-06-25 Jun-Ting Hsieh , Sidhanth Mohanty , Jeff Xu

In this work we introduce a novel approach, based on sampling, for finding assignments that are likely to be solutions to stochastic constraint satisfaction problems and constraint optimisation problems. Our approach reduces the size of the…

Optimization and Control · Mathematics 2015-09-22 Roberto Rossi , Brahim Hnich , S. Armagan Tarim , Steven Prestwich
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