Related papers: Compartmental analysis of nuclear imaging data for…
Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the second of a…
Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the first of a…
Positron Emission Tomography using 2-[18F]-2deoxy-D-glucose as radiotracer (FDG-PET) is currently one of the most frequently applied functional imaging methods in clinical applications. The interpretation of FDG-PET data requires…
The present paper proposes a novel computational method for parametric imaging of nuclear medicine data. The mathematical procedure is general enough to work for compartmental models of diverse complexity and is effective in the…
Parametric imaging is a compartmental approach that processes nuclear imaging data to estimate the spatial distribution of the kinetic parameters governing tracer flow. The present paper proposes a novel and efficient computational method…
The radioactive glucose analogue 2-deoxy-2-[18F]fluoro-D-glucose (FDG) is widely used to reconstruct glucose metabolism and other biological functions in cells and tissues. The analysis of data on the time course of FDG tracer distribution…
This paper describes a general approach to the compartmental modeling of nuclear data based on spectral analysis and statistical optimization. We utilize the renal physiology as test case and validate the method against both synthetic data…
One common way to test for diabetes is the Oral Glucose Tolerance Test or OGTT. Most common methods for the analysis of the data on this test are wasteful of much of the information contained therein. We propose to model blood glucose…
The gut microbiome plays a crucial role in human health, yet the mechanisms underlying host-microbiome interactions remain unclear, limiting its translational potential. Recent microbiome multiomics studies, particularly paired…
Motivation: There is a growing need to integrate mechanistic models of biological processes with computational methods in healthcare in order to improve prediction. We apply data assimilation in the context of Type 2 diabetes to understand…
As the demand for more descriptive machine learning models grows within medical imaging, bottlenecks due to data paucity will exacerbate. Thus, collecting enough large-scale data will require automated tools to harvest data/label pairs from…
This study proposes an automatic technique for liver segmentation in computed tomography (CT) images. Localization of the liver volume is based on the correlation with an optimized set of liver templates developed by the authors that allows…
We develop a model-based methodology for integrating gene-set information with an experimentally-derived gene list. The methodology uses a previously reported sampling model, but takes advantage of natural constraints in the…
A common test for the diagnosis of type 2 diabetes is the Oral Glucose Tolerance Test (OGTT). Recent developments in the study of OGTT tests have framed it as a Bayesian inverse problem. These data analysis advances promise great…
The paper deals with modeling the liver perfusion intended to improve quantitative analysis of the tissue scans provided by the contrast-enhanced computed tomography (CT). For this purpose, we developed a model of dynamic transport of the…
Correlation networks are commonly used to infer associations between microbes and metabolites. The resulting p-values are then corrected for multiple comparisons using existing methods such as the Benjamini and Hochberg procedure to control…
Quantized neural networks typically require smaller memory footprints and lower computation complexity, which is crucial for efficient deployment. However, quantization inevitably leads to a distribution divergence from the original…
We build a model for the hepatic fatty acid metabolism and its metabolic and genetic regulations. The model has two functioning modes: synthesis and oxidation of fatty acids. We provide a sufficient condition (the strong lipolytic…
Transfer learning and joint learning approaches are extensively used to improve the performance of Convolutional Neural Networks (CNNs). In medical imaging applications in which the target dataset is typically very small, transfer learning…
In the Oral Glucose Tolerance Test (OGTT), a patient, after an overnight fast ingests a load of glucose. Then measurements of glucose concentration are taken every 30 minutes during two hours. The test is used to aid diagnosis of diabetes,…