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Antimicrobial resistance (AMR) poses a significant public health and economic challenge, increasing treatment costs and reducing antibiotic effectiveness. This study employs machine learning to analyze genomic and epidemiological data from…

Quantitative Methods · Quantitative Biology 2025-09-05 Shubham Mishra , The Anh Han , Bruno Silvester Lopes , Shatha Ghareeb , Zia Ush Shamszaman

Background and Objectives: Multidrug Resistance (MDR) is a critical global health issue, causing increased hospital stays, healthcare costs, and mortality. This study proposes an interpretable Machine Learning (ML) framework for MDR…

Antimicrobial resistance is becoming a major threat to public health throughout the world. Researchers are attempting to contrast it by developing both new antibiotics and patient-specific treatments. In the second case, whole-genome…

Applications · Statistics 2023-07-25 Clara Grazian

Multi-strain pathogens such as Group A Streptococcus, Streptococcus pneumoniae, and Staphylococcus aureus cause millions of infections each year with a substantial health burden. Control of multi-strain pathogens can be complicated by the…

Populations and Evolution · Quantitative Biology 2025-02-03 Nefel Tellioglu , Nicholas Geard , Rebecca H. Chisholm

The acquisition of Antimicrobial Multidrug Resistance (AMR) in patients admitted to the Intensive Care Units (ICU) is a major global concern. This study analyses data in the form of multivariate time series (MTS) from 3476 patients recorded…

Staphylococcus aureus is a coccal bacterium, which divides by binary fission. After division the cells remain attached giving rise to small clusters, with a characteristic 'bunch of grapes' morphology. S. aureus is an important human…

Subcellular Processes · Quantitative Biology 2016-03-03 Adam J. M. Wollman , Helen Miller , Simon Foster , Mark C. Leake

Antimicrobial resistance (AMR) poses a global health threat, reducing the effectiveness of antibiotics and complicating clinical decision-making. To address this challenge, we introduce abx_amr_simulator, a Python-based simulation package…

Machine Learning · Computer Science 2026-03-13 Joyce Lee , Seth Blumberg

It has long been known that antibiotic treatment will not completely kill off a bacteria population. For many species a small fraction of bacteria is not sensitive to antibiotics. These bacteria are said to persist. Recently it has been…

Probability · Mathematics 2012-03-29 Olivier Garet , Regine Marchand , Rinaldo B. Schinazi

Background: Microbiota have evolved to acclimate themselves to many environments. Humanity is become ever increasingly medicated and many of those medications are antibiotics. Sadly, Microbiota are adapting to medication and with each…

Genomics · Quantitative Biology 2012-09-27 Casey Richardson

Antimicrobial Resistance (RAM) poses a significant threat to global public health, making important medicines less useful. While the medical and biological reasons behind RAM are well studied, we still don't know enough about how false…

Physics and Society · Physics 2025-05-29 Laurance Fakih , Andrei Halanay

Studies of social and group behavior in interacting organisms require high-throughput analysis of the motion of a large number of individual subjects. Computer vision techniques offer solutions to specific tracking problems, and allow…

Quantitative Methods · Quantitative Biology 2015-06-12 Yi Deng , Philip Coen , Mingzhai Sun , Joshua W. Shaevitz

Malaria remains a serious health challenge in the Comoros Islands, despite ongoing control efforts. Past studies have shown reductions in cases due to prevention and treatment measures, but little work has been done to forecast future…

Antimicrobial resistance to drugs (AMR), a global threat to human and animal health, is often regarded as resulting from cooperative behaviour. Moreover, microbes generally evolve in volatile environments that, together with demographic…

Populations and Evolution · Quantitative Biology 2024-06-18 Lluís Hernández-Navarro , Matthew Asker , Mauro Mobilia

Whole genome sequencing of pathogens from multiple hosts in an epidemic offers the potential to investigate who infected whom with unparalleled resolution, potentially yielding important insights into disease dynamics and the impact of…

The intestinal microbiota plays important roles in digestion and resistance against entero-pathogens. As with other ecosystems, its species composition is resilient against small disturbances but strong perturbations such as antibiotics can…

Quantitative Methods · Quantitative Biology 2015-06-04 Vanni Bucci , Serena Bradde , Giulio Biroli , Joao B. Xavier

Malaria is the leading cause of death globally, especially in sub-Saharan African countries claiming over 400,000 deaths globally each year, underscoring the critical need for continued efforts to combat this preventable and treatable…

Malaria can be prevented, diagnosed, and treated; however, every year, there are more than 200 million cases and 200.000 preventable deaths. Malaria remains a pressing public health concern in low- and middle-income countries, especially in…

Machine Learning · Statistics 2023-03-20 África Periáñez , Andrew Trister , Madhav Nekkar , Ana Fernández del Río , Pedro L. Alonso

Tuberculosis (TB) is one of the deadliest diseases worldwide, with 1,5 million fatalities every year along with potential devastating effects on society, families and individuals. To address this alarming burden, vaccines can play a…

A bacterial colony may develop a small number of cells genetically identical to, but phenotypically different from other normally growing bacteria. These so-called persister cells keep themselves in a dormant state and thus are insensitive…

Molecular Networks · Quantitative Biology 2010-02-11 Yan Fu , Meng Zhu , Jianhua Xing

Humans, domestic animals, orchard crops, and ornamental plants are commonly treated with antibiotics in response to bacterial infection. By curing infectious individuals, antibiotic therapy might limit the spread of contagious disease among…

Populations and Evolution · Quantitative Biology 2020-01-22 Thomas Caraco