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We construct a constant size population model allowing for general selective interactions and extreme reproductive events. It generalizes the idea of (Krone and Neuhauser 1997) who represented the selection by allowing individuals to sample…

Probability · Mathematics 2020-04-17 Adrian Gonzalez Casanova , Charline Smadi

We consider the spatial Lambda-Fleming-Viot process model for frequencies of genetic types in a population living in R^d, in the special case in which there are just two types of individual, labelled 0 and 1. At time zero, everyone in the…

Probability · Mathematics 2011-11-28 N. Berestycki , A. M. Etheridge , A. Veber

Duality plays an important role in population genetics. It can relate results from forwards-in-time models of allele frequency evolution with those of backwards-in-time genealogical models; a well known example is the duality between the…

Populations and Evolution · Quantitative Biology 2019-08-09 Robert C. Griffiths , Paul A. Jenkins , Sabin Lessard

We consider a population with two types of individuals, distinguished by the resources required for reproduction: type-$0$ (small) individuals need a fractional resource unit of size $\vartheta \in (0,1)$, while type-$1$ (large) individuals…

Probability · Mathematics 2025-10-29 Gerold Alsmeyer , Fernando Cordero , Hannah Dopmeyer

We consider the spatial Lambda-Fleming-Viot process model for frequencies of genetic types in a population living in R^d, with two types of individuals (0 and 1) and natural selection favouring individuals of type 1. We first prove that the…

Probability · Mathematics 2020-10-01 Alison Etheridge , Amandine Veber , Feng Yu

In populations competing for resources, it is natural to ask whether consuming fewer resources provides any selective advantage. To answer this question, we propose a Wright- Fisher model with two types of individuals: the inefficient…

Probability · Mathematics 2020-09-11 Adrian Gonzalez Casanova , Veronica Miro Pina , Juan Carlos Pardo

The Wright-Fisher diffusion is a fundamentally important model of evolution encompassing genetic drift, mutation, and natural selection. Suppose you want to infer the parameters associated with these processes from an observed sample path.…

Statistics Theory · Mathematics 2024-10-22 Paul A. Jenkins

Meta-analysis is a statistical method to combine results from multiple clinical or genomic studies with the same or similar research problems. It has been widely use to increase statistical power in finding clinical or genomic differences…

Statistics Theory · Mathematics 2019-08-05 Yusi Fang , Shaowu Tang , Zhiguang Huo , George C. Tseng , Yongseok Park

This paper explores large sample properties of the two-parameter $(\alpha,\theta)$ Poisson--Dirichlet Process in two contexts. In a Bayesian context of estimating an unknown probability measure, viewing this process as a natural extension…

Probability · Mathematics 2008-05-21 Lancelot F. James

Diffusion theory is a central tool of modern population genetics, yielding simple expressions for fixation probabilities and other quantities that are not easily derived from the underlying Wright-Fisher model. Unfortunately, the textbook…

Populations and Evolution · Quantitative Biology 2022-12-19 Camila Bräutigam , Matteo Smerlak

Characterizing time-evolution of allele frequencies in a population is a fundamental problem in population genetics. In the Wright-Fisher diffusion, such dynamics is captured by the transition density function, which satisfies well-known…

Probability · Mathematics 2013-08-06 Matthias Steinrücken , Y. X. Rachel Wang , Yun S. Song

In a (two-type) Wright-Fisher diffusion with directional selection and two-way mutation, let $x$ denote today's frequency of the beneficial type, and given $x$, let $h(x)$ be the probability that, among all individuals of today's…

Populations and Evolution · Quantitative Biology 2015-07-10 Ute Lenz , Sandra Kluth , Ellen Baake , Anton Wakolbinger

The Wright--Fisher diffusion is important in population genetics in modelling the evolution of allele frequencies over time subject to the influence of biological phenomena such as selection, mutation, and genetic drift. Simulating paths of…

Populations and Evolution · Quantitative Biology 2023-01-16 Jaromir Sant , Paul A. Jenkins , Jere Koskela , Dario Spanò

One-dimensional Fisher-Wright diffusion process on the interval $(0,1)$ with mutations is considered. This is a widely known model in population genetics. The goal of the paper is an exponential recurrence of the process, which also implies…

Probability · Mathematics 2021-11-02 Roman Sineokiy , Alexander Veretennikov

We consider the problem of learning two families of time-evolving random measures from indirect observations. In the first model, the signal is a Fleming--Viot diffusion, which is reversible with respect to the law of a Dirichlet process,…

Statistics Theory · Mathematics 2014-11-19 Omiros Papaspiliopoulos , Matteo Ruggiero , Dario Spanò

Wright-Fisher diffusions describe the evolution of the type composition of an infinite haploid population with two types (say type $0$ and type $1$) subject to neutral reproductions, and possibly selection and mutations. In the present…

Probability · Mathematics 2022-12-21 Grégoire Véchambre

Diffusion models have shown their effectiveness in generation tasks by well-approximating the underlying probability distribution. However, diffusion models are known to suffer from an amplified inherent bias from the training data in terms…

Machine Learning · Computer Science 2024-10-04 Yujin Choi , Jinseong Park , Hoki Kim , Jaewook Lee , Saerom Park

In this paper, we study the asymptotic (large time) behavior of a selection-mutation-competition model for a population structured with respect to a phenotypic trait, when the rate of mutation is very small. We assume that the reproduction…

Analysis of PDEs · Mathematics 2015-11-17 Àngel Calsina , Sílvia Cuadrado , Laurent Desvillettes , Gaël Raoul

We present a robust method which translates information on the speed of coming down from infinity of a genealogical tree into sampling formulae for the underlying population. We apply these results to population dynamics where the genealogy…

Probability · Mathematics 2012-02-01 Julien Berestycki , Nathanael Berestycki , Vlada Limic

Seed banks are a common characteristics to many plant species, which allow storage of genetic diversity in the soil as dormant seeds for various periods of time. We investigate an above-ground population following a Fisher-Wright model with…

Populations and Evolution · Quantitative Biology 2017-01-13 Bendix Koopmann , Johannes Müller , Aurélien Tellier , Daniel Živković