English

Looking down in the ancestral selection graph: A probabilistic approach to the common ancestor type distribution

Populations and Evolution 2015-07-10 v2 Probability

Abstract

In a (two-type) Wright-Fisher diffusion with directional selection and two-way mutation, let xx denote today's frequency of the beneficial type, and given xx, let h(x)h(x) be the probability that, among all individuals of today's population, the individual whose progeny will eventually take over in the population is of the beneficial type. Fearnhead [Fearnhead, P., 2002. The common ancestor at a nonneutral locus. J. Appl. Probab. 39, 38-54] and Taylor [Taylor, J. E., 2007. The common ancestor process for a Wright-Fisher diffusion. Electron. J. Probab. 12, 808-847] obtained a series representation for h(x)h(x). We develop a construction that contains elements of both the ancestral selection graph and the lookdown construction and includes pruning of certain lines upon mutation. Besides being interesting in its own right, this construction allows a transparent derivation of the series coefficients of h(x)h(x) and gives them a probabilistic meaning.

Keywords

Cite

@article{arxiv.1409.0642,
  title  = {Looking down in the ancestral selection graph: A probabilistic approach to the common ancestor type distribution},
  author = {Ute Lenz and Sandra Kluth and Ellen Baake and Anton Wakolbinger},
  journal= {arXiv preprint arXiv:1409.0642},
  year   = {2015}
}

Comments

Theoretical Population Biology, in press