Related papers: Biological Tissue Imaging with a Position and Time…
Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging (MSI) is a powerful technique for spatially resolved molecular profiling and cancer biomarker discovery. Recent advances, including a novel multiomics workflow, enable…
A prototype particle tracking telescope has been constructed using Timepix and Medipix ASIC hybrid pixel assemblies as the six sensing planes. Each telescope plane consisted of one 1.4 cm2 assembly, providing a 256x256 array of 55 micron…
We present a new technique for obtaining simultaneous multimodal quantitative phase and fluorescence microscopy of biological cells, providing both quantitative phase imaging and molecular specificity using a single camera. Our system is…
The upgrade of the China Spallation Neutron Source (CSNS-II) will raise the proton beam power to 500 kW. Consequently, the existing Timepix3-based detector systems, limited to a count rate of 80 Mhits/s, will encounter severe saturation…
The development of CMOS pixel sensors with column parallel read-out and integrated zero-suppression has resulted in a full size, nearly 1 Megapixel, prototype with ~100 \mu s read-out time. Its performances are quite close to the ILD vertex…
Mass spectrometry imaging (MSI) as an analytical tool for bio-molecular and bio-medical research targets, accurate compound localization and identification. In terms of dedicated instrumentation, this translates into the demand for more…
In this work we explore readout architectures for the simultaneous high-resolution timing and bidimensional tracking of charged particles with Resistive Plate Chambers (TOF-tracker) and for the accurate detection of gamma rays for PET…
Time-resolved fluorescence imaging is a key tool in biomedical applications, as it allows to non-invasively obtain functional and structural information. However, the big amount of collected data introduces challenges in both acquisition…
A plug-and-play PhotonPix single-photon detector with a logical signal output is developed for applications requiring ultimate timing precision down to 10 ps over a wide dynamic photon flux range. The heart of the detector is an Exosens…
We demonstrate the application of event-driven Timepix3-based detectors in combination with a double-sided velocity-map-imaging spectrometer to record the full 3D momentum of charged particles at the free-electron-laser facility FLASH. We…
As the Chinese Spallation Neutron Source enters Phase II, the increase in proton beam power will lead to a further boost in the intensity of pulsed neutron beams. To address the demand for higher event-rate readout electronics for…
A new type of gaseous micropattern particle detector based on a closed-cell microcavity plasma panel sensor is reported. The first device was fabricated with 1 x 1 x 2 mm cells. It has shown very clean signals of 0.6 to 2.5 volt amplitude,…
The work shows the ability to visualize radiotracers used in SPECT with a system based on a coded aperture mask and a hybrid pixel Timepix detector with the CdTe sensor. Characterization of the system using X-rays and radioactive sources…
The proposed Circular Electron Positron Collider (CEPC) imposes new challenges for the vertex detector in terms of pixel size and material budget. A Monolithic Active Pixel Sensor (MAPS) prototype called TaichuPix, based on a column drain…
For the advancement of the understanding of timing systematics in pixelized readout chips and for the benefit of future fast timing detectors to aid 4D tracking technology in the HL-LHC, we have performed detailed studies of the timing…
Temporal focusing two-photon microscopy enables high resolution imaging of fine structures in vivo over a large volume. A limitation of temporal focusing is that signal-to-background ratio and resolution degrade rapidly with increasing…
Advances in solid-state technology have enabled the development of silicon photomultiplier sensor arrays capable of sensing individual photons. Combined with high-frequency time-to-digital converters (TDCs), this technology opens up the…
To achieve high precision and accuracy for mass measurements of exotic nuclei by Time-of-flight (TOF) methods: high-resolution beam-line magnetic-rigidity time-of-flight (B$\rho$-TOF) and in-ring isochronous mass spectrometry (IMS), a…
A system based on commercially available items, such as a laser diode, emitting in the visible range $\sim 400$ nm,and multimode fiber patches, fused fiber splitters and optical switches may be assembled,for time calibration of…
Space-based gamma-ray telescopes such as the Fermi Large Area Telescope have used single sided silicon strip detectors to measure the position of charged particles produced by incident gamma rays with high resolution. At energies in the…