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We investigate the consequences of periodic, on-off glucose infusion on the glucose-insulin regulatory system on the basis of a system-level mathematical model with two explicit time delays. Studying the effects of such infusion protocols…
Cardiovascular disease is a large worldwide healthcare issue; symptoms often present suddenly with minimal warning. The electrocardiogram (ECG) is a fast, simple and reliable method of evaluating the health of the heart, by measuring…
Being able to predict clinical parameters in order to diagnose gait disorders in a patient is of great value in planning treatments. It is known that \textit{decision parameters} such as cadence, step length, and walking speed are critical…
Continuous, ubiquitous monitoring through wearable sensors has the potential to collect useful information about users' context. Heart rate is an important physiologic measure used in a wide variety of applications, such as fitness tracking…
In this paper, several advanced data-driven nonlinear identification techniques are compared on a specific problem: a simplified glucoregulatory system modeling example. This problem represents a challenge in the development of an…
Photoplethysmogram (PPG) signal-based blood pressure (BP) estimation is a promising candidate for modern BP measurements, as PPG signals can be easily obtained from wearable devices in a non-invasive manner, allowing quick BP measurement.…
Trace clustering has increasingly been applied to find homogenous process executions. However, current techniques have difficulties in finding a meaningful and insightful clustering of patients on the basis of healthcare data. The resulting…
Electrocardiogram~(ECG), a key bioelectrical time-series signal, is crucial for assessing cardiac health and diagnosing various diseases. Given its time-series format, ECG data is often incorporated into pre-training datasets for…
Data collected in clinical trials are often composed of multiple types of variables. For example, laboratory measurements and vital signs are longitudinal data of continuous or categorical variables, adverse events may be recurrent events,…
Chronic kidney disease (CKD) is a gradual loss of renal function over time, and it increases the risk of mortality, decreased quality of life, as well as serious complications. The prevalence of CKD has been increasing in the last couple of…
We consider the problem of sequentially testing for changes in the mean parameter of a time series, compared to a benchmark period. Most tests in the literature focus on the null hypothesis of a constant mean versus the alternative of a…
While the Artificial Pancreas is effective in regulating the blood glucose in the safe range of 70-180 mg/dl in type 1 diabetic patients, the high intra-patient variability, as well as exogenous meal disturbances, poses a serious challenge.…
The increase in the collection of biological data allows for the individual and longitudinal monitoring of hematological or urine biomarkers. However, identifying abnormal behavior in these biological sequences is not trivial. Moreover, the…
Cardiovascular disorders account for nearly 1 in 3 deaths in the United States. Care for these disorders are often determined during visits to acute care facilities, such as hospitals. While the length of stay in these settings represents…
In the case of diabetes, fingertip pricking for a blood sample is inconvenient for glucose measurement. Invasive approaches like laboratory test and one-touch glucometer enhance the risk of blood-related infections. To mitigate this…
In this work, we present the Senbiosys blood pressure monitoring algorithm (SB-BPM) that solely requires a photoplethysmography (PPG) signal. The technology is based on pulse wave analysis (PWA) of PPG signals retrieved from different body…
People with diabetes are at risk of developing an eye disease called diabetic retinopathy (DR). This disease occurs when high blood glucose levels cause damage to blood vessels in the retina. Computer-aided DR diagnosis is a promising tool…
As the senior population rapidly increases, it is challenging yet crucial to provide effective long-term care for seniors who live at home or in senior care facilities. Smart senior homes, which have gained widespread interest in the…
Medical diagnoses can shape and change the life of a person drastically. Therefore, it is always best advised to collect as much evidence as possible to be certain about the diagnosis. Unfortunately, in the case of the Brugada Syndrome…
Cross-grating phase microscopy (CGM) is a quantitative phase microscopy technique based on the association of a 2-dimensional diffraction grating (cross-grating) and a regular camera sensor, separated by a millimetric distance. This simple…