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Motivated by experimental results on the interplay between molecular motors and tau proteins, we extend lattice-based models of intracellular transport to include a second species of particle which locally influences the motor-filament…

Subcellular Processes · Quantitative Biology 2010-04-27 H. Grzeschik , R. J. Harris , L. Santen

Muscles sense internally generated and externally applied forces, responding to these in a coordinated hierarchical manner at different time scales. The center of the basic unit of the muscle, the sarcomeric M-band, is perfectly placed to…

Tissues and Organs · Quantitative Biology 2021-09-22 Neil Ibata , Eugene M. Terentjev

Metal to insulator transitions (MITs) driven by strong electronic correlations are common in condensed matter systems, and are associated with some of the most remarkable collective phenomena in solids, including superconductivity and…

Strongly Correlated Electrons · Physics 2019-12-20 G. G. Guzmán-Verri , R. T. Brierley , P. B. Littlewood

Mechano-electric coupling (MEC) in atrial tissue has received sparse investigation to date, despite the well-known association between chronic atrial dilation and atrial fibrillation (AF). Of note, no fewer than six different mechanisms…

Quantitative Methods · Quantitative Biology 2020-09-30 Marta Varela , Adity Roy , Jack Lee

The rheology of biological cells is not only determined by their cytoskeletal networks, but also by the molecular motors that crosslink and contract them. Recently it has been found that the assemblies of myosin II molecular motors in…

Subcellular Processes · Quantitative Biology 2020-07-13 Justin Grewe , Ulrich S. Schwarz

Cells and tissues exert forces and can actively change shape. This strikingly autonomous behavior is powered by the cytoskeleton, which includes an active gel of actin filaments, crosslinks, and myosin molecular motors. Although individual…

Soft Condensed Matter · Physics 2017-07-26 José Alvarado , Misha Sheinman , Abhinav Sharma , Fred C. MacKintosh , Gijsje H. Koenderink

The stochastic driving force exerted by a single molecular motor (e.g., a kinesin, or myosin) moving on a periodic molecular track (microtubule, actin filament, etc.) is discussed from a general viewpoint open to experimental test. An…

Statistical Mechanics · Physics 2009-10-31 Michael E. Fisher , Anatoly B. Kolomeisky

The strong repulsive core of the nucleon-nucleon (NN) interaction at short distances prevents nucleons from becoming close to each other. This gives rise to high-momentum nucleons in the nucleus that cannot be explained in the context of…

Nuclear Experiment · Physics 2015-06-11 Nadia Fomin

The Bessel-inspired behavior of parton densities at small Bjorken x values is used along with `frozen' and analytic modifications of the strong coupling constant [1] to study the so-called EMC effect. Among other results, this approach…

High Energy Physics - Phenomenology · Physics 2019-05-01 A. Kotikov , B. Shaikhatdenov , P. Zhang

We analyze the stretching elasticity of a wormlike chain with a tension discontinuity resulting from a Hookean spring connecting its backbone to a fixed point. The elasticity of isolated semiflexible filaments has been the subject in a…

Biological Physics · Physics 2016-05-25 Mohammadhosein Razbin , Panayotis Benetatos , Annette Zippelius

The origin of biological motion can be traced back to the function of molecular motor proteins. Cytoplasmic dynein and kinesin transport organelles within our cells moving along a polymeric filament, the microtubule. The motion of the…

Statistical Mechanics · Physics 2015-06-25 Imre Derenyi , Tamas Vicsek

Crosslinked semi-flexible and flexible filaments that are actively deformed by molecular motors occur in various natural settings, such as the ordered eukaryotic flagellum, and the disordered cytoskeleton. The deformation of these composite…

Biological Physics · Physics 2018-10-02 Arvind Gopinath , Raghunath Chelakkot , L. Mahadevan

Since the discovery that the ratio of inclusive charged lepton (per-nucleon) cross sections from a nucleus A to the deuteron is not unity - even in deep inelastic scattering kinematics - a great deal of experimental and theoretical effort…

Nuclear Experiment · Physics 2014-08-19 Simona Malace , David Gaskell , Douglas W. Higinbotham , Ian Cloet

In this paper, we examine the hypothesis that the nuclear EMC effect comes merely from the N-N SRC pairs inside the nucleus and that the properties of N-N SRC pair are universal among the various nuclei, using the conventional $x$-rescaling…

Nuclear Theory · Physics 2023-02-24 Rong Wang , Na-Na Ma , Tao-Feng Wang

We calculate the cross sections for elastic scattering and Zeeman relaxation in binary collisions of molecules in the ro-vibrational ground state of a $^2\Sigma$ electronic state and the Zeeman state with the electron spin projection…

Chemical Physics · Physics 2015-06-16 Jie Cui , Roman V. Krems

Contradictory experimental reports on the relationship between efficiency and stimulation frequency have hindered mechanistic understanding in converting neural activity into mechanical work during muscle contraction. To resolve this issue,…

Biological Physics · Physics 2026-05-08 Jiaxiang Xu , Bin Chen

A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of…

Subcellular Processes · Quantitative Biology 2021-06-22 Sage A Malingen , Kaitlyn Hood , Eric Lauga , Anette Hosoi , Thomas L Daniel

The EMC effect is studied in the perturbative QCD hard pomeron approach. In the limit $x\rightarrow 0$ and for a nucleus with a constant density the effect is found to be a function of a single variable which combines its $x$-, $Q$- and…

High Energy Physics - Phenomenology · Physics 2016-09-01 N. Armesto , M. A. Braun

Objective: Hepatic encephalopathy (HE) is a potentially reversible brain dysfunction caused by liver failure. Altered synaptic plasticity is supposed to play a major role in the pathophysiology of HE. Here, we used paired associative…

This paper studies the influence of electric fields on the skyrmion lattice (SkL) in insulating skyrmion compounds with weak magnetoelectric (ME) coupling. The ME coupling mechanism is an interaction between the external electric field $E$…

Other Condensed Matter · Physics 2017-03-01 Alex J. Kruchkov , Henrik M. Rønnow