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Early detection of clinical outcomes such as cancer may be predicted based on longitudinal biomarker measurements. Tracking longitudinal biomarkers as a way to identify early disease onset may help to reduce mortality from diseases like…

The transformation of the regular vasculature in normal tissue into a highly inhomogeneous tumor specific capillary network is described by a theoretical model incorporating tumor growth, vessel cooption, neo-vascularization, vessel…

Tissues and Organs · Quantitative Biology 2016-09-08 K. Bartha , H. Rieger

In this paper, we would like to quantitatively measure the tumor volume contained in the breast imaged by the Digital Breast Tomosynthesis (DBT), a reconstructed 3D image. The estimated volume will add to the prognostic value of risk…

Medical Physics · Physics 2018-04-17 Bocar Wane

This paper provides a framework for estimating the mean and variance of a high-dimensional normal density. The main setting considered is a fixed number of vector following a high-dimensional normal distribution with unknown mean and…

Methodology · Statistics 2019-05-07 Shyamalendu Sinha , Jeffrey D. Hart

Purpose - To characterise and assess the quality of published research evaluating artificial intelligence (AI) methods for ovarian cancer diagnosis or prognosis using histopathology data. Methods - A search of PubMed, Scopus, Web of…

Image and Video Processing · Electrical Eng. & Systems 2023-06-19 Jack Breen , Katie Allen , Kieran Zucker , Pratik Adusumilli , Andy Scarsbrook , Geoff Hall , Nicolas M. Orsi , Nishant Ravikumar

Living cells actively regulate their volume in response to changes in the extra-cellular environment, such as osmolarity and chemo-attractant concentration. While the basic physical mechanisms of volume regulation are understood from the…

Biological Physics · Physics 2025-04-30 Ram M. Adar

Purpose: Measuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom…

In this paper, we propose two new performance metrics, coined the Version Innovation Age (VIA) and the Age of Incorrect Version (AoIV) for real-time monitoring of a two-state Markov process over an unreliable channel. We analyze their…

Information Theory · Computer Science 2024-02-01 Mehrdad Salimnejad , Marios Kountouris , Anthony Ephremides , Nikolaos Pappas

In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour…

Tissues and Organs · Quantitative Biology 2019-05-15 Sounak Sadhukhan , S. K. Basu

The influence of sex and age on cerebral perfusion is recognized, but the specific impacts on regional cerebral blood flow (CBF) and vascular risk remain to be fully characterized. In this study, 3D pseudo-continuous arterial spin labeling…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Sneha Noble , Neelam Sinha , Vaanathi Sundareshan , Thomas Gregor Issac

We obtain the upper error bounds of robust estimators for mean vector, using the median-of-means (MOM) method. The method is designed to handle data with heavy tails and contamination, with only a finite second moment, which is weaker than…

Statistics Theory · Mathematics 2026-05-12 Yuxuan Wang , Yiming Chen , Hanchao Wang , Lixin Zhang

Background: Clinical prediction models for a health condition are commonly evaluated regarding performance for a population, although decisions are made for individuals. The classic view relates uncertainty in risk estimates for individuals…

Current vision-language models (VLMs) in medicine are primarily designed for categorical question answering (e.g., "Is this normal or abnormal?") or qualitative descriptive tasks. However, clinical decision-making often relies on…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Yongcheng Yao , Yongshuo Zong , Raman Dutt , Yongxin Yang , Sotirios A Tsaftaris , Timothy Hospedales

In this article we shall trace the historical development of tumour growth laws, which in a quantitative fashion describe the increase in tumour mass/volume over time. These models are usually formulated in terms of differential equations…

Tissues and Organs · Quantitative Biology 2013-02-11 P. Gerlee

How exponentially growing cells maintain size homeostasis is an important fundamental problem. Recent single-cell studies in prokaryotes have uncovered the adder principle, where cells on average, add a fixed size (volume) from birth to…

Subcellular Processes · Quantitative Biology 2016-07-28 Khem Raj Ghusinga , Cesar A. Vargas-Garcia , Abhyudai Singh

The researchers have drawn much attention about the birth weight of newborn babies in the last three decades. The birth weight is one of the vital roles in the babys health. So many researchers such as (2),(1) and (4) analyzed the birth…

Data Analysis, Statistics and Probability · Physics 2010-02-11 D. Nagarajan , P. Sunitha , V. Nagarajan , V. Seethalekshmi

Over the past decades, statisticians and machine-learning researchers have developed literally thousands of new tools for the reduction of high-dimensional data in order to identify the variables most responsible for a particular trait.…

Machine Learning · Statistics 2012-05-31 Chamont Wang , Jana Gevertz , Chaur-Chin Chen , Leonardo Auslender

The maximum volume ($\Omega$) of a droplet that can remain attached to a horizontal fiber defines the stability limit of droplet-fiber interactions, phenomena common in nature and critical to diverse engineering applications. Existing…

Fluid Dynamics · Physics 2025-12-29 Yi Zhang , Apurav Tambe , Zhao Pan

Purpose: Understanding how the pancreas changes is critical for detecting deviations in type 2 diabetes and other pancreatic disease. We measure pancreas size and shape using morphological measurements from ages 0 to 90. Our goals are to 1)…

Pre-main sequence (PMS) models provide invaluable tools for the study of star forming regions as they allow to assign masses and ages to young stars. Thus it is of primary importance to test the models against observations of PMS stars with…

Solar and Stellar Astrophysics · Physics 2015-05-30 Mario Gennaro , Pier Giorgio Prada Moroni , Emanuele Tognelli