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We investigate a class of stochastic chemical reaction networks with $n{\ge}1$ chemical species $S_1$, \ldots, $S_n$, and whose complexes are only of the form $k_iS_i$, $i{=}1$,\ldots, $n$, where $(k_i)$ are integers. The time evolution of…

Probability · Mathematics 2024-08-29 Lucie Laurence , Philippe Robert

The ability to detect whether a species (or dimension) is zero in Chemical Reaction Networks (CRN), Vector Addition Systems, or Petri Nets is known to increase the power of these models -- making them capable of universal computation. While…

We consider leader election in anonymous radio networks modeled as simple undirected connected graphs. Nodes communicate in synchronous rounds. Nodes are anonymous and execute the same deterministic algorithm, so symmetry can be broken only…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-02-10 Avery Miller , Andrzej Pelc , Ram Narayan Yadav

Continuous time Markov chains are commonly used as models for the stochastic behavior of chemical reaction networks. More precisely, these Stochastic Chemical Reaction Networks (SCRNs) are frequently used to gain a mechanistic understanding…

Probability · Mathematics 2025-11-18 Simone Bruno , Yi Fu , Felipe A. Campos , Domitilla Del Vecchio , Ruth J. Williams

Well-mixed chemical reaction networks (CRNs) contain many distinct chemical species with copy numbers that fluctuate in correlated ways. While those correlations are typically monitored via Monte Carlo sampling of stochastic trajectories,…

Statistical Mechanics · Physics 2026-01-14 John P. Zima , Schuyler B. Nicholson , Todd R. Gingrich

The catalytic reaction system (CRS) formalism by Hordijk and Steel is a versatile method to model autocatalytic biochemical reaction networks. It is particularly suited, and has been widely used, to study self-sustainment and…

Molecular Networks · Quantitative Biology 2023-08-16 Dimitri Loutchko

While the field of first-principles explorations into chemical reaction space has been continuously growing, the development of strategies for analyzing resulting chemical reaction networks (CRNs) is lagging behind. A CRN consists of…

Chemical Physics · Physics 2022-12-19 Paul L. Türtscher , Markus Reiher

Chemical reaction networks (CRNs) model the behavior of chemical reactions in well-mixed solutions and they can be designed to perform computations. In this tutorial we give an overview of various computational models for CRNs. Moreover, we…

Emerging Technologies · Computer Science 2018-11-27 Robert Brijder

Timing is of fundamental importance in biology and our life. Borrowing ideas from mechanism, we map our clock signals onto a gear system, in pursuit of better depiction of a clock signal implemented with chemical reaction networks (CRNs).…

Molecular Networks · Quantitative Biology 2018-02-23 Chuan Zhang , Lulu Ge , Xiaohu You

The problem of completing a large low rank matrix using a subset of revealed entries has received much attention in the last ten years. The main result of this paper gives a necessary and sufficient condition, stated in the language of…

Statistics Theory · Mathematics 2021-04-19 Sourav Chatterjee

This paper presents new results about the optimization based generation of chemical reaction networks (CRNs) of higher deficiency. Firstly, it is shown that the graph structure of the realization containing the maximal number of reactions…

Molecular Networks · Quantitative Biology 2011-03-23 Gabor Szederkenyi , Katalin M. Hangos , Tamas Peni

We consider the task of computing functions $f: \mathbb{N}^k\to \mathbb{N}$, where $ \mathbb{N}$ is the set of natural numbers, by finite teams of agents modelled as deterministic finite automata. The computation is carried out in a…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-10-03 Debasish Pattanayak , Andrzej Pelc

As practitioners seek to surpass the current reliability and quality frontier of monolithic models, Compound AI Systems consisting of many language model inference calls are increasingly employed. In this work, we construct systems, which…

Artificial Intelligence · Computer Science 2024-07-25 Jared Quincy Davis , Boris Hanin , Lingjiao Chen , Peter Bailis , Ion Stoica , Matei Zaharia

Neural operators have recently become popular tools for designing solution maps between function spaces in the form of neural networks. Differently from classical scientific machine learning approaches that learn parameters of a known…

Machine Learning · Computer Science 2022-09-07 Huaiqian You , Yue Yu , Marta D'Elia , Tian Gao , Stewart Silling

The online estimation of the derivative of an input signal is widespread in control theory and engineering. In the realm of chemical reaction networks (CRN), this raises however a number of specific issues on the different ways to achieve…

Quantitative Methods · Quantitative Biology 2023-07-11 Mathieu Hemery , François Fages

An algorithm is given in this paper for the computation of dynamically equivalent weakly reversible realizations with the maximal number of reactions, for chemical reaction networks (CRNs) with mass action kinetics. The original problem…

Dynamical Systems · Mathematics 2011-07-05 Gabor Szederkenyi , Katalin M. Hangos , Zsolt Tuza

Reservoir computing - information processing based on untrained recurrent neural networks with random connections - is expected to depend on the nonlinear properties of the neurons and the resulting oscillatory, chaotic, or fixpoint…

Neural and Evolutionary Computing · Computer Science 2024-11-18 Claus Metzner , Achim Schilling , Andreas Maier , Patrick Krauss

Continuous-time Markov chains are frequently used as stochastic models for chemical reaction networks, especially in the growing field of systems biology. A fundamental problem for these Stochastic Chemical Reaction Networks (SCRNs) is to…

Probability · Mathematics 2023-04-12 Felipe A. Campos , Simone Bruno , Yi Fu , Domitilla Del Vecchio , Ruth J. Williams

Marcello, in 1997, formally proved that chemical kinetics can make a universal computer i.e they can replicate any digital circuit. Recently, Soloveichik et al. showed that chemical kinetics can perform fast and reliable Turing Universal…

Emerging Technologies · Computer Science 2018-08-15 Shalin Shah , Manish Gupta

Stochastic chemical processes are described by the chemical master equation satisfying the law of mass-action. We first ask whether the dual master equation, which has the same steady state as the chemical master equation, but with inverted…

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