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The locations of different mRNA molecules can be revealed by multiplexed in situ RNA detection. By assigning detected mRNA molecules to individual cells, it is possible to identify many different cell types in parallel. This in turn enables…

Information Theory · Computer Science 2023-12-08 Axel Andersson , Andrea Behanova , Carolina Wählby , Filip Malmberg

Spectral Clustering is a popular technique to split data points into groups, especially for complex datasets. The algorithms in the Spectral Clustering family typically consist of multiple separate stages (such as similarity matrix…

Machine Learning · Computer Science 2019-11-04 Yifei Wang , Rui Liu , Yong Chen , Hui Zhangs , Zhiwen Ye

Decision trees are widely used for classification and regression tasks in a variety of application fields due to their interpretability and good accuracy. During the past decade, growing attention has been devoted to globally optimized…

Machine Learning · Computer Science 2025-01-28 Antonio Consolo , Edoardo Amaldi , Andrea Manno

Motivated by analyzing complicated and non-stationary time series, we study a generalization of the scattering transform (ST) that includes broad neural activation functions, which is called neural activation ST (NAST). On the whole, NAST…

Machine Learning · Statistics 2020-11-24 Gi-Ren Liu , Yuan-Chung Sheu , Hau-Tieng Wu

For the first time the phenomenon of cellular structure coarsening are consistently analysed from the positions of kinetic, hydrodynamic and stochastodynamic theories of nonequilibrium statistical systems. Thereby micro-, meso- and…

Condensed Matter · Physics 2015-06-25 S. B. Goryachev

We introduce a random recursive tree model with two communities, called balanced community modulated random recursive tree, or BCMRT in short. In this setting, pairs of nodes of different type appear sequentially. Each node of the pair…

Statistics Theory · Mathematics 2024-02-12 Anna Ben-Hamou , Vasiliki Velona

Despite significant progress of generative models in the natural sciences, their controllability remains challenging. One fundamentally missing aspect of molecular or protein generative models is an inductive bias that can reflect…

Machine Learning · Computer Science 2023-08-25 Jannis Born , Matteo Manica

Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal structures to actively transport proteins to one location on…

Biological Physics · Physics 2022-06-22 Harmen Wierenga , Pieter Rein ten Wolde

We study the entanglement entropy of a random tensor network (RTN) using tools from free probability theory. Random tensor networks are simple toy models that help the understanding of the entanglement behavior of a boundary region in the…

Quantum Physics · Physics 2024-07-04 Khurshed Fitter , Faedi Loulidi , Ion Nechita

We revisit the Bayesian Context Trees (BCT) modelling framework for discrete time series, which was recently found to be very effective in numerous tasks including model selection, estimation and prediction. A novel representation of the…

Methodology · Statistics 2023-03-21 Ioannis Papageorgiou , Ioannis Kontoyiannis

Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an…

Cell Behavior · Quantitative Biology 2014-03-05 Leili Shahriyari , Natalia L. Komarova

Branching of bilayer membranes appear in the inverted hexagonal phase as well as in metastable states of the lamellar phase such as membrane fusion intermediates. A method for estimating the line tension of the branching junction is…

Soft Condensed Matter · Physics 2012-05-02 Hiroshi Noguchi

We consider a broad class of continuous-time two-type population size-dependent Markov Branching Processes. The offspring distribution can depend on the current (alive) and total (dead and alive) populations. Using stochastic approximation…

Probability · Mathematics 2023-04-04 Khushboo Agarwal , Veeraruna Kavitha

The recent development of single-cell transcriptomics has enabled gene expression to be measured in individual cells instead of being population-averaged. Despite this considerable precision improvement, inferring regulatory networks…

Molecular Networks · Quantitative Biology 2017-11-28 Ulysse Herbach , Arnaud Bonnaffoux , Thibault Espinasse , Olivier Gandrillon

We study in this paper the dynamics of quantum nanoelectronic resonant tunneling diodes (RTDs) as excitable neuromorphic spike generators. We disclose the mechanisms by which the RTD creates excitable all-or-nothing spikes and we identify a…

Pattern Formation and Solitons · Physics 2021-03-10 Ignacio Ortega , Oreste Piro , Bruno Romeira , Julien Javaloyes

The micro-randomized trial (MRT) is an experimental design that can be used to develop optimal mobile health interventions. In MRTs, interventions in the form of notifications or messages are sent through smart phones to individuals,…

Methodology · Statistics 2022-02-14 Shuangning Li , Stefan Wager

We study the graph structure of large random dissections of polygons sampled according to Boltzmann weights, which encompasses the case of uniform dissections or uniform $p$-angulations. As their number of vertices $n$ goes to infinity, we…

Probability · Mathematics 2014-02-13 Nicolas Curien , Bénédicte Haas , Igor Kortchemski

Our main goal is to study a class of processes whose increments are generated via a cellular automata rule. Given the increments of a simple biased random walk, a new sequence of (dependent) Bernoulli random variables is produced. It is…

Probability · Mathematics 2017-10-24 Andrea Collevecchio , Kais Hamza , Yunxuan Liu

Collective cell migration is a multicellular phenomenon that arises in various biological contexts, including cancer and embryo development. "Collectiveness" can be promoted by cell-cell interactions such as co-attraction and contact…

Cell Behavior · Quantitative Biology 2023-10-03 Viktoria Freingruber , Kevin J. Painter , Mariya Ptashnyk , Linus Schumacher

It has recently been suggested that the competition for a finite pool of microRNAs (miRNA) gives rise to effective interactions among their common targets (competing endogenous RNAs or ceRNAs) that could prove to be crucial for…

Molecular Networks · Quantitative Biology 2015-06-11 Matteo Figliuzzi , Enzo Marinari , Andrea De Martino