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Background: With the fast development of next generation sequencing technologies, increasing numbers of genomes are being de novo sequenced and assembled. However, most are in fragmental and incomplete draft status, and thus it is often…

Genomics · Quantitative Biology 2020-02-28 Binghang Liu , Yujian Shi , Jianying Yuan , Xuesong Hu , Hao Zhang , Nan Li , Zhenyu Li , Yanxiang Chen , Desheng Mu , Wei Fan

Thanks to rapidly evolving sequencing techniques, the amount of genomic data at our disposal is growing increasingly large. Determining the gene structure is a fundamental requirement to effectively interpret gene function and regulation.…

Genomics · Quantitative Biology 2017-11-28 Jasper Zuallaert , Mijung Kim , Yvan Saeys , Wesley De Neve

Despite their significant advantages over competing technologies, nanopore sequencers are plagued by high error rates, due to physical characteristics of the nanopore and inherent noise in the biological processes. It is thus paramount not…

Information Theory · Computer Science 2025-10-27 Anisha Banerjee , Yonatan Yehezkeally , Antonia Wachter-Zeh , Eitan Yaakobi

Grammatical error correction can be viewed as a low-resource sequence-to-sequence task, because publicly available parallel corpora are limited. To tackle this challenge, we first generate erroneous versions of large unannotated corpora…

Computation and Language · Computer Science 2019-07-03 Yo Joong Choe , Jiyeon Ham , Kyubyong Park , Yeoil Yoon

Tensor decompositions have been successfully applied to compress neural networks. The compression algorithms using tensor decompositions commonly minimize the approximation error on the weights. Recent work assumes the approximation error…

Machine Learning · Computer Science 2023-08-07 Jetze T. Schuurmans , Kim Batselier , Julian F. P. Kooij

The accurate quantification of gene expression levels is crucial for transcriptome study. Microarray platforms are commonly used for simultaneously interrogating thousands of genes in the past decade, and recently RNA-Seq has emerged as a…

Applications · Statistics 2014-08-01 Zhaonan Sun , Thomas Kuczek , Yu Zhu

Research on long non-coding RNAs (lncRNAs) has garnered significant attention due to their critical roles in gene regulation and disease mechanisms. However, the complexity and diversity of lncRNA sequences, along with the limited knowledge…

Genomics · Quantitative Biology 2024-11-07 Wei Wang , Zhichao Hou , Xiaorui Liu , Xinxia Peng

Grammatical error correction, like other machine learning tasks, greatly benefits from large quantities of high quality training data, which is typically expensive to produce. While writing a program to automatically generate realistic…

Computation and Language · Computer Science 2018-10-02 Sudhanshu Kasewa , Pontus Stenetorp , Sebastian Riedel

Large language models make remarkable progress in reasoning capabilities. Existing works focus mainly on deductive reasoning tasks (e.g., code and math), while another type of reasoning mode that better aligns with human learning, inductive…

Computation and Language · Computer Science 2025-03-18 Kedi Chen , Zhikai Lei , Fan Zhang , Yinqi Zhang , Qin Chen , Jie Zhou , Liang He , Qipeng Guo , Kai Chen , Wei Zhang

Motivation: The mapping of RNA-seq reads to their transcripts of origin is a fundamental task in transcript expression estimation and differential expression scoring. Where ambiguities in mapping exist due to transcripts sharing sequence,…

Genomics · Quantitative Biology 2015-01-28 James Hensman , Peter Glaus , Antti Honkela , Magnus Rattray

Conversational systems rely heavily on speech recognition to interpret and respond to user commands and queries. Despite progress on speech recognition accuracy, errors may still sometimes occur and can significantly affect the end-user…

Human-Computer Interaction · Computer Science 2025-06-23 Sadia Nowrin , Keith Vertanen

We introduce an improved version of RECKONER, an error corrector for Illumina whole genome sequencing data. By modifying its workflow we reduce the computation time even 10 times. We also propose a new method of determination of $k$-mer…

Genomics · Quantitative Biology 2017-03-03 Maciej Dlugosz , Sebastian Deorowicz , Marek Kokot

Real-world data contains various kinds of errors. Before analyzing data, one usually needs to process the raw data. However, traditional data processing based on exactly match often misses lots of valid information. To get high-quality…

Databases · Computer Science 2017-12-19 Dong Deng

Accurate genome sequencing can improve our understanding of biology and the genetic basis of disease. The standard approach for generating DNA sequences from PacBio instruments relies on HMM-based models. Here, we introduce Distilled…

Error correction is an important capability when applying large language models (LLMs) to facilitate user typing on mobile devices. In this paper, we use LLMs to synthesize a high-quality dataset of error correction pairs to evaluate and…

Machine Learning · Computer Science 2025-05-27 Yanxiang Zhang , Zheng Xu , Shanshan Wu , Yuanbo Zhang , Daniel Ramage

Error correction is essential for modern computing systems, enabling information to be processed accurately even in the presence of noise. Here, we demonstrate a new approach which exploits an error correcting phase that emerges in a system…

Query Reformulation(QR) is a set of techniques used to transform a user's original search query to a text that better aligns with the user's intent and improves their search experience. Recently, zero-shot QR has been shown to be a…

Information Retrieval · Computer Science 2024-04-08 Kaustubh Dhole , Eugene Agichtein

A key initial step in several natural language processing (NLP) tasks involves embedding phrases of text to vectors of real numbers that preserve semantic meaning. To that end, several methods have been recently proposed with impressive…

Computation and Language · Computer Science 2019-04-26 Rohit Voleti , Julie M. Liss , Visar Berisha

Accurate and comprehensive clinical documentation is crucial for delivering high-quality healthcare, facilitating effective communication among providers, and ensuring compliance with regulatory requirements. However, manual transcription…

Computation and Language · Computer Science 2024-06-12 Anjanava Biswas , Wrick Talukdar

We propose a novel word embedding pre-training approach that exploits writing errors in learners' scripts. We compare our method to previous models that tune the embeddings based on script scores and the discrimination between correct and…

Computation and Language · Computer Science 2019-07-05 Youmna Farag , Marek Rei , Ted Briscoe