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Methods for global measurement of transcript abundance such as microarrays and RNA-Seq generate datasets in which the number of measured features far exceeds the number of observations. Extracting biologically meaningful and experimentally…

Methodology · Statistics 2022-06-22 Lei Ding , Gabriel E. Zentner , Daniel J. McDonald

Large language models (LLMs) have shown strong ability in generating rich representations across domains such as natural language processing and generation, computer vision, and multimodal learning. However, their application in biomedical…

Genomics · Quantitative Biology 2025-09-30 Luxuan Zhang , Douglas Jiang , Qinglong Wang , Haoqi Sun , Feng Tian

Unsupervised sentence embedding representation has become a hot research topic in natural language processing. As a tensor, sentence embedding has two critical properties: direction and norm. Existing works have been limited to constraining…

Computation and Language · Computer Science 2025-03-18 Tianyu Zong , Bingkang Shi , Hongzhu Yi , Jungang Xu

Hyperparameter tuning is one of the the most time-consuming parts in machine learning. Despite the existence of modern optimization algorithms that minimize the number of evaluations needed, evaluations of a single setting may still be…

Machine Learning · Computer Science 2024-03-27 Philip Buczak , Andreas Groll , Markus Pauly , Jakob Rehof , Daniel Horn

Automatic cell image segmentation methods in connectomics produce merge and split errors, which require correction through proofreading. Previous research has identified the visual search for these errors as the bottleneck in interactive…

Computer Vision and Pattern Recognition · Computer Science 2017-04-05 Daniel Haehn , Verena Kaynig , James Tompkin , Jeff W. Lichtman , Hanspeter Pfister

Ensembling multiple predictions is a widely used technique for improving the accuracy of various machine learning tasks. One obvious drawback of ensembling is its higher execution cost during inference. In this paper, we first describe our…

Machine Learning · Computer Science 2019-03-11 Hiroshi Inoue

Alignment-based sequence similarity searches, while accurate for some type of sequences, can produce incorrect results when used on more divergent but functionally related sequences that have undergone the sequence rearrangements observed…

Genomics · Quantitative Biology 2015-01-21 Ivan Borozan , Stuart Watt , Vincent Ferretti

Recent advancements in data-to-text generation largely take on the form of neural end-to-end systems. Efforts have been dedicated to improving text generation systems by changing the order of training samples in a process known as…

Computation and Language · Computer Science 2021-02-09 Ernie Chang , Hui-Syuan Yeh , Vera Demberg

A critical challenge in single-cell RNA sequencing (scRNA-seq) integration is resolving the tension between eliminating batch effects and maintaining biological fidelity. While recent evidence indicates that batch effects manifest…

Machine Learning · Computer Science 2026-05-19 Xichen Yan , Zelin Zang , Changxi Chi , Jingbo Zhou , Chang Yu , Jinlin Wu , Shenghui Cheng , Fuji Yang , Jiebo Luo , Zhen Lei , Stan Z. Li

Storage systems have a strong need for substantially improving their error correction capabilities, especially for long-term storage where the accumulating errors can exceed the decoding threshold of error-correcting codes (ECCs). In this…

Information Theory · Computer Science 2018-11-12 Pulakesh Upadhyaya , Anxiao , Jiang

Historical documents frequently suffer from damage and inconsistencies, including missing or illegible text resulting from issues such as holes, ink problems, and storage damage. These missing portions or gaps are referred to as lacunae. In…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Jaydeep Borkar , David A. Smith

Machine Reading Comprehension (MRC) is an active field in natural language processing with many successful developed models in recent years. Despite their high in-distribution accuracy, these models suffer from two issues: high training…

Computation and Language · Computer Science 2021-07-16 Razieh Baradaran , Hossein Amirkhani

DNA synthesis is considered as one of the most expensive components in current DNA storage systems. In this paper, focusing on a common synthesis machine, which generates multiple DNA strands in parallel following a fixed supersequence,we…

Information Theory · Computer Science 2025-05-13 Yajuan Liu , Tolga M. Duman

de Bruijn graph-based algorithms are one of the two most widely used approaches for de novo genome assembly. A major limitation of this approach is the large computational memory space requirement to construct the de Bruijn graph, which…

Data Structures and Algorithms · Computer Science 2011-07-11 Chengxi Ye , Zhanshan Sam Ma , Charles H. Cannon , Mihai Pop , Douglas W. Yu

Motivation: High-throughput sequencing enables expression analysis at the level of individual transcripts. The analysis of transcriptome expression levels and differential expression estimation requires a probabilistic approach to properly…

Genomics · Quantitative Biology 2012-10-10 Peter Glaus , Antti Honkela , Magnus Rattray

Functional simulation is an essential step in digital hardware design. Recently, there has been a growing interest in leveraging Large Language Models (LLMs) for hardware testbench generation tasks. However, the inherent instability…

Software Engineering · Computer Science 2024-11-14 Ruidi Qiu , Grace Li Zhang , Rolf Drechsler , Ulf Schlichtmann , Bing Li

The focus of our paper is the identification and correction of non-word errors in OCR text. Such errors may be the result of incorrect insertion, deletion, or substitution of a character, or the transposition of two adjacent characters…

Computation and Language · Computer Science 2021-06-24 Junxia Lin , Johannes Ledolter

Due to the lack of parallel data in current Grammatical Error Correction (GEC) task, models based on Sequence to Sequence framework cannot be adequately trained to obtain higher performance. We propose two data synthesis methods which can…

Computation and Language · Computer Science 2021-12-28 Liner Yang , Chencheng Wang , Yun Chen , Yongping Du , Erhong Yang

Motivation: Whole-genome high-coverage sequencing has been widely used for personal and cancer genomics as well as in various research areas. However, in the lack of an unbiased whole-genome truth set, the global error rate of variant calls…

Genomics · Quantitative Biology 2018-07-27 Heng Li

Accurately finding the wrong words in the automatic speech recognition (ASR) hypothesis and recovering them well-founded is the goal of speech error correction. In this paper, we propose a non-autoregressive speech error correction method.…

Computation and Language · Computer Science 2024-07-19 Yuchun Shu , Bo Hu , Yifeng He , Hao Shi , Longbiao Wang , Jianwu Dang
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