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Dengue is a vector-borne disease and 40% of world population is at risk. Dengue transcends international borders and can be found in tropical and subtropical regions around the world, predominantly in urban and semi-urban areas. A model for…

Populations and Evolution · Quantitative Biology 2016-08-10 Helena Sofia Rodrigues , M. Teresa T. Monteiro , Delfim F. M. Torres , Ana Clara Silva , Carla Sousa , Cláudia Conceição

This paper is devoted to the study of optimal release strategies to control vector-borne diseases, such as dengue, Zika, chikungunya and malaria. Two techniques are considered: the sterile insect one (SIT), which consists in releasing…

Optimization and Control · Mathematics 2023-07-24 Luis Almeida , Jesús Bellver Arnau , Yannick Privat , Carlota Rebelo

In this study, we develop and analyze a deterministic two-strain host-vector model for dengue transmission that incorporates key immuno-epidemiological mechanisms, including temporary cross-immunity, antibody-dependent enhancement (ADE),…

Dynamical Systems · Mathematics 2026-01-13 Burcu Gürbüz , Aytül Gökçe , Joseph Páez Chávez , Thomas Götz

We apply optimal control theory to a tuberculosis model given by a system of ordinary differential equations. Optimal control strategies are proposed to minimize the cost of interventions, considering reinfection and post-exposure…

Optimization and Control · Mathematics 2013-07-15 Cristiana J. Silva , Delfim F. M. Torres

As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a first phase, the vaccination process is studied as a new compartment in the model, and different ways of…

Optimization and Control · Mathematics 2013-11-26 Helena Sofia Rodrigues , M. Teresa T. Monteiro , Delfim F. M. Torres

Dengue is a serious health problem in the Philippines. In 2016, the Department of Health of the country launched a dengue vaccination campaign using Dengvaxia. However, the campaign was mired with controversy and the use of Dengvaxia was…

Populations and Evolution · Quantitative Biology 2019-08-07 Michelle N. Raza , Randy L. Caga-anan

Managing infectious diseases is a world public health issue, plagued by uncertainties. In this paper, we analyze the problem of viable control of a dengue outbreak under uncertainty. For this purpose, we develop a controlled Ross-Macdonald…

Optimization and Control · Mathematics 2018-02-23 Lilian Sofia Salcedo Sepulveda , Michel De Lara

We delve into the interactions between a prey-predator and a vector-borne epidemic system, driven by agro-ecological motivations. This system involves an ODE, two reaction--diffusion PDEs and one reaction--diffusion--advection PDE. It has…

Analysis of PDEs · Mathematics 2024-02-13 Baptiste Maucourt

We construct an epidemic model for the transmission of dengue fever with an early-life stage in the vector dynamics and age-structure within hosts. The early-life stage of the vector is modeled via a general function that supports multiple…

Populations and Evolution · Quantitative Biology 2019-10-01 Fabio Sanchez , Juan G. Calvo

The transmission of vector infectious diseases, which produces complex spatiotemporal patterns, is analyzed by a periodically forced two-dimensional cellular automata model. The system, which comprises three population levels, is introduced…

Cellular Automata and Lattice Gases · Physics 2008-10-03 L. B. L. Santos , M. C. Costa , S. T. R. Pinho , R. F. S. Andrade , F. R. Barreto , M. G. Teixeira , M. L. Barreto

We apply optimal control theory to a tuberculosis model given by a system of ordinary differential equations. Optimal control strategies are proposed to minimize the cost of interventions. Numerical simulations are given using data from…

Optimization and Control · Mathematics 2012-07-23 Cristiana J. Silva , Delfim F. M. Torres

Dengue continues to pose a major global threat, infecting nearly 390 million people annually. Recognizing the pivotal role of vector competence (vc), recent research focuses on mosquito parameters to inform transmission modeling and vector…

Populations and Evolution · Quantitative Biology 2025-11-07 Piyumi Chathurangika , Tharushika Peiris , Lakmini S. Premadasa , S. S. N. Perera , Kushani De Silva

In this paper we propose two nonlinear models for the control of anthracnose disease. The first is an ordinary differential equation (ODE) model which represents the within-host evolution of the disease. The second includes spatial…

Optimization and Control · Mathematics 2014-06-17 David Fotsa , Elvis Houpa , David Békollé , Christopher Thron , Michel Ndoumbé

This work addresses the optimal birth control problem for invasive species in a spatial environment. We apply the method of semigroups to qualitatively analyze a size-structured population model in which individuals occupy a position in a…

Optimization and Control · Mathematics 2021-04-12 Manoj Kumar , Syed Abbas

We review the optimal control of systems modeling the dynamics of tuberculosis. Time dependent control functions are introduced in the mathematical models, representing strategies for the improvement of the treatment and cure of active…

Optimization and Control · Mathematics 2015-08-18 Cristiana J. Silva , Delfim F. M. Torres

Mathematical modelling can help to explain the nature and dynamics of infection transmissions, as well as support a policy for implementing those strategies that are most likely to bring public health and economic benefits. The paper…

Optimization and Control · Mathematics 2015-09-01 Roman Denysiuk , Cristiana J. Silva , Delfim F. M. Torres

We consider an agro-ecologically motivated coupling between a prey-predator system and a vector-borne epidemic system. The coupled system contains one ODE, two reaction-diffusion PDEs and one reaction-diffusionadvection PDE; it has no…

Analysis of PDEs · Mathematics 2022-12-23 Léo Girardin , Baptiste Maucourt

Dengue, which affects millions of people each year, is one of the most common diseases transmitted by infected \textit{Aedes aegypti} mosquitoes. In the Philippines, the annual economic cost of dengue infections is estimated at around PHP…

Optimization and Control · Mathematics 2026-01-19 Kyrho Corum , Renier Mendoza , Victoria May P. Mendoza , Arrianne Crystal Velasco

Mosquitoes are vectors of viral diseases with epidemic potential in many regions of the world, and in absence of vaccines or therapies, their control is the main alternative. Chemical control through insecticides has been one of the…

Populations and Evolution · Quantitative Biology 2021-04-07 Pastor Pérez Estigarribia , Pierre-Alexandre Bliman , Christian Schaerer

The emergence of mutant lineages within a viral species has become a public health problem, as the existing treatments and drugs are usually more effective on the original lineages than in the mutant ones. The following manuscript presents…