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Mathematical models play an increasingly important role in the interpretation of biological experiments. Studies often present a model that generates the observations, connecting hypothesized process to an observed pattern. Such generative…

Populations and Evolution · Quantitative Biology 2014-06-18 Steven A. Frank

In a previous paper (Ref. [1]) the presence of dark energy in our universe was explained as the fingerprint of a comprehensive, much older and expanding multiverse with positive spatial curvature, whose space-time is spanned by this energy,…

General Relativity and Quantum Cosmology · Physics 2018-09-06 Rebhan Eckhard

Models of diffusion driven pattern formation that rely on the Turing mechanism are utilized in many areas of science. However, many such models suffer from the defect of requiring fine tuning of parameters or an unrealistic separation of…

Other Quantitative Biology · Quantitative Biology 2015-03-17 Thomas Butler , Nigel Goldenfeld

We study how macroscopic observational constraints restrict admissible microscopic explanatory structures when no intrinsic order or dynamics is assumed a priori. Starting from an unordered collection of measurement outcomes, we formulate…

Statistical Mechanics · Physics 2026-02-09 Akihisa Ichiki

How many parameters are required for a model to execute a given task? It has been argued that large language models, pre-trained via self-supervised learning, exhibit emergent capabilities such as multi-step reasoning as their number of…

Machine Learning · Computer Science 2024-09-23 Ingvar Ziemann , Nikolai Matni , George J. Pappas

Latent space models are powerful statistical tools for modeling and understanding network data. While the importance of accounting for uncertainty in network analysis has been well recognized, the current literature predominantly focuses on…

Statistics Theory · Mathematics 2025-08-15 Jinming Li , Shihao Wu , Chengyu Cui , Gongjun Xu , Ji Zhu

Several problems in neuroimaging and beyond require inference on the parameters of multi-task sparse hierarchical regression models. Examples include M/EEG inverse problems, neural encoding models for task-based fMRI analyses, and climate…

The possibility that the mass hierarchy is intimately associated with the compositeness level of the matters is proposed in supersymmetric gauge theory. This implies, for instance, that the preons constituting top quark consists of the…

High Energy Physics - Phenomenology · Physics 2009-10-30 M. Hayakawa

Motivated by the absence of any direct signal of new physics so far, we present a simple supersymmetric model in which the up-type Higgs mass-squared parameter crosses zero at a scale close to the weak scale. Such a theory may be motivated…

High Energy Physics - Phenomenology · Physics 2008-11-26 Yasunori Nomura , David Poland

Physical models of biological systems can become difficult to interpret when they have a large number of parameters. But the models themselves actually depend on (i.e. are sensitive to) only a subset of those parameters. Rigorously…

Biological Physics · Physics 2018-11-27 Chieh-Ting Hsu , Gary J. Brouhard , Paul François

In many areas of engineering and sciences, decision rules and control strategies are usually designed based on nominal values of relevant system parameters. To ensure that a control strategy or decision rule will work properly when the…

Probability · Mathematics 2020-06-16 Xinjia Chen

It is often claimed that the fundamental laws of physics are deterministic and time-symmetric and that therefore our experience of the passage of time is an illusion. This paper will critically discuss these claims and show that they are…

Quantum Physics · Physics 2023-04-20 Barbara Drossel

In this paper we give a brief review of semiparametric theory, using as a running example the common problem of estimating an average causal effect. Semiparametric models allow at least part of the data-generating process to be unspecified…

Methodology · Statistics 2017-09-20 Edward H. Kennedy

Cosmological parameter estimation from forthcoming experiments promise to reach much greater precision than current constraints. As statistical errors shrink, the required control over systematic errors increases. Therefore, models or…

Cosmology and Nongalactic Astrophysics · Physics 2020-10-07 José Luis Bernal , Nicola Bellomo , Alvise Raccanelli , Licia Verde

Large language models have revolutionized artificial intelligence by enabling large, generalizable models trained through self-supervision. This paradigm has inspired the development of scientific foundation models (FMs). However, applying…

The macroscopic response of short fiber reinforced composites is dependent on an extensive range of microstructural parameters. Thus, micromechanical modeling of these materials is challenging and in some cases, computationally expensive.…

Machine Learning · Computer Science 2022-10-04 J. Friemann , B. Dashtbozorg , M. Fagerström , S. M. Mirkhalaf

The relationship according to which one physical theory encompasses the domain of empirical validity of another is widely known as "reduction." Here it is argued that one popular methodology for showing that one theory reduces to another,…

History and Philosophy of Physics · Physics 2019-10-23 Joshua Rosaler

The aim of this paper is to show a connection between an extended theory of statistical experiments on the one hand and the foundation of quantum theory on the other hand. The main aspects of this extension are: One assumes a hyperparameter…

Quantum Physics · Physics 2012-07-10 Inge S. Helland

This chapter presents key concepts and theoretical results for analyzing estimation and inference in high-dimensional models. High-dimensional models are characterized by having a number of unknown parameters that is not vanishingly small…

Statistics Theory · Mathematics 2018-06-12 Alexandre Belloni , Victor Chernozhukov , Denis Chetverikov , Christian Hansen , Kengo Kato

Singularities of a statistical model are the elements of the model's parameter space which make the corresponding Fisher information matrix degenerate. These are the points for which estimation techniques such as the maximum likelihood…

Statistics Theory · Mathematics 2019-07-25 Nhat Ho , XuanLong Nguyen