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In this paper we consider large state space continuous time Markov chains (MCs) arising in the field of systems biology. For density dependent families of MCs that represent the interaction of large groups of identical objects, Kurtz has…

Performance · Computer Science 2015-03-04 Alessio Angius , Gianfranco Balbo , Marco Beccuti , Enrico Bibbona , Andras Horvath , Roberta Sirovich

We introduce a class of continuous-time bivariate phase-type distributions for modeling dependencies from common shocks. The construction uses continuous-time Markov processes that evolve identically until an internal common-shock event,…

Statistics Theory · Mathematics 2025-12-01 Martin Bladt , Oscar Peralta , Jorge Yslas

We study the Markov chain on $\mathbf{F}_p$ obtained by applying a function $f$ and adding $\pm\gamma$ with equal probability. When $f$ is a linear function, this is the well-studied Chung--Diaconis--Graham process. We consider two cases:…

Probability · Mathematics 2022-03-08 Jimmy He

Markov chains have been widely employed as a fundamental model in the studies of probabilistic and stochastic communicating and concurrent systems. It is well-understood that decomposition techniques play a key role in reachability analysis…

Quantum Physics · Physics 2018-02-15 Ji Guan , Yuan Feng , Mingsheng Ying

We consider a Markov chain obtained by random iterations of Lipschitz maps $T_i$ chosen with a probability $p_i(x)$ depending on the current position $x$. We assume this system has a property of "contraction on average", that is $\sum_i…

Probability · Mathematics 2012-06-22 Olivier Durieu

Markov chains on the non-negative quadrant of dimension $d$ are often used to model the stochastic dynamics of the number of $d$ entities, such as $d$ chemical species in stochastic reaction networks. The infinite state space poses…

Probability · Mathematics 2024-10-17 Wai-Tong Louis Fan , Jinsu Kim , Chaojie Yuan

The convergence rate of a Markov chain to its stationary distribution is typically assessed using the concept of total variation mixing time. However, this worst-case measure often yields pessimistic estimates and is challenging to infer…

Statistics Theory · Mathematics 2026-02-06 Geoffrey Wolfer , Pierre Alquier

In this paper, we address technical difficulties that arise when applying Markov chain Monte Carlo (MCMC) to hierarchical models designed to perform clustering in the space of latent parameters of subject-wise generative models.…

Quantitative Methods · Quantitative Biology 2020-12-15 Yu Yao , Klaas E. Stephan

The continuous-time quantum walks (CTQWs) are a fundamental tool in the development of quantum algorithms. Recently, it was shown that discretizations of p-adic Schr\"odinger equations give rise to continuous-time quantum Markov chains…

Quantum Physics · Physics 2026-02-26 W. A. Zúñiga-Galindo , L. F. Chacón-Cortés

Case-Bsed Reasoning (CBR) is a recent theory for problem-solving and learning in computers and people.Broadly construed it is the process of solving new problems based on the solution of similar past problems. In the present paper we…

Artificial Intelligence · Computer Science 2014-01-07 Michael Gr. Voskoglou

Inference for continuous-time Markov chains (CTMCs) becomes challenging when the process is only observed at discrete time points. The exact likelihood is intractable, and existing methods often struggle even in medium-dimensional…

Methodology · Statistics 2025-07-23 Tao Tang , Lachlan Astfalck , David Dunson

Markov Chain Monte Carlo (MCMC) algorithms are routinely used to draw samples from distributions with intractable normalization constants. However, standard MCMC algorithms do not apply to doubly-intractable distributions in which there are…

Computation · Statistics 2012-07-02 Iain Murray , Zoubin Ghahramani , David MacKay

Stochastic processes on complex networks, where each node is in one of several compartments, and neighboring nodes interact with each other, can be used to describe a variety of real-world spreading phenomena. However, computational…

Social and Information Networks · Computer Science 2019-06-28 Gerrit Großmann , Luca Bortolussi

A block Markov chain is a Markov chain whose state space can be partitioned into a finite number of clusters such that the transition probabilities only depend on the clusters. Block Markov chains thus serve as a model for Markov chains…

Probability · Mathematics 2023-04-03 Jaron Sanders , Alexander Van Werde

One of the most widely used samplers in practice is the component-wise Metropolis-Hastings (CMH) sampler that updates in turn the components of a vector valued Markov chain using accept-reject moves generated from a proposal distribution.…

Computation · Statistics 2017-03-22 Jinyoung Yang , Evgeny Levi , Radu V. Craiu , Jeffrey S. Rosenthal

The problem of sampling from the stationary distribution of a Markov chain finds widespread applications in a variety of fields. The time required for a Markov chain to converge to its stationary distribution is known as the classical…

Quantum Physics · Physics 2022-09-14 Shantanav Chakraborty , Kyle Luh , Jérémie Roland

Single type and multitype branching process have been used to study the dynamics of a variety of stochastic birth-death type phenomena in biology and physics. Their use in epidemiology goes back to Whittle's study of a…

Dynamical Systems · Mathematics 2017-10-03 Evan Milliken

We consider chemical reaction networks modeled by a discrete state and continuous in time Markov process for the vector copy number of the species and provide a novel particle filter method for state and parameter estimation based on exact…

Molecular Networks · Quantitative Biology 2021-02-24 Muruhan Rathinam , Mingkai Yu

We connect the problem of semi-supervised clustering to constrained Markov aggregation, i.e., the task of partitioning the state space of a Markov chain. We achieve this connection by considering every data point in the dataset as an…

Machine Learning · Computer Science 2022-05-11 Sophie Steger , Bernhard C. Geiger , Marek Smieja

Under suitable assumptions, the dynamic behaviour of a chemical reaction network is governed by an autonomous set of polynomial ordinary differential equations over continuous variables representing the concentrations of the reactant…

Dynamical Systems · Mathematics 2014-07-15 Matthew D. Johnston , David Siegel