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Our genomes influence nearly every aspect of human biology from molecular and cellular functions to phenotypes in health and disease. Human genetics studies have now associated hundreds of thousands of differences in our DNA sequence…

Other Quantitative Biology · Quantitative Biology 2023-07-27 IGVF Consortium

DNA technologies have evolved significantly in the past years enabling the sequencing of a large number of genomes in a short time. Nevertheless, the underlying computational problem is hard, and many technical factors and limitations…

Data Structures and Algorithms · Computer Science 2024-11-15 Lucas P. Ramos , Felipe A. Louza , Guilherme P. Telles

Secondary contact between divergent populations or incipient species may result in the exchange and introgression of genomic material. We develop a simple DNA sequence measure, called Gmin, which is designed to identify genomic regions…

Populations and Evolution · Quantitative Biology 2017-02-08 Anthony J. Geneva , Sarah B. Kingan , Daniel Garrigan

Due to the recent evolution of sequencing techniques, the number of available genomes is rising steadily, leading to the possibility to make large scale genomic comparison between sets of close species. An interesting question to answer is:…

Computational Engineering, Finance, and Science · Computer Science 2014-09-24 Bassam AlKindy , Jean-François Couchot , Christophe Guyeux , Arnaud Mouly , Michel Salomon , Jacques M. Bahi

As protein therapeutics play an important role in almost all medical fields, numerous studies have been conducted on proteins using artificial intelligence. Artificial intelligence has enabled data driven predictions without the need for…

Quantitative Methods · Quantitative Biology 2023-03-30 Myeonghun Lee , Kyoungmin Min

Automatic extraction of chemical structures from scientific literature plays a crucial role in accelerating research across fields ranging from drug discovery to materials science. Patent documents, in particular, contain molecular…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Lucas Morin , Gerhard Ingmar Meijer , Valéry Weber , Luc Van Gool , Peter W. J. Staar

In recent years, there has been significant growth in the commercial applications of generative models, licensed and distributed by model developers to users, who in turn use them to offer services. In this scenario, there is a need to…

Computer Vision and Pattern Recognition · Computer Science 2023-11-10 Jianwei Fei , Zhihua Xia , Benedetta Tondi , Mauro Barni

The typical process for classifying and submitting a newly sequenced virus to the NCBI database involves two steps. First, a BLAST search is performed to determine likely family candidates. That is followed by checking the candidate…

Genomics · Quantitative Biology 2016-03-22 Troy Hernandez , Jie Yang

With small-scale quantum processors transitioning from experimental physics labs to industrial products, these processors allow us to efficiently compute important algorithms in various fields. In this paper, we propose a quantum algorithm…

Quantum Physics · Physics 2020-05-22 Aritra Sarkar , Zaid Al-Ars , Carmen G. Almudever , Koen Bertels

In medical sciences, a biomarker is "a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention". Molecular…

Quantitative Methods · Quantitative Biology 2015-08-03 Frederico G. C. Arnoldi , Rodrigo F. Rodrigues , Celio L. Silva

Principal component analysis (PCA) is routinely used in population genetics to assess genetic structure. With chromosomal reference genomes and population-scale whole genome-sequencing becoming increasingly accessible, contemporary studies…

Populations and Evolution · Quantitative Biology 2025-01-22 L. Moritz Blumer , Jeffrey M. Good , Richard Durbin

Advancements in genomic research such as high-throughput sequencing techniques have driven modern genomic studies into "big data" disciplines. This data explosion is constantly challenging conventional methods used in genomics. In parallel…

Genomics · Quantitative Biology 2023-10-06 Tianwei Yue , Yuanxin Wang , Longxiang Zhang , Chunming Gu , Haoru Xue , Wenping Wang , Qi Lyu , Yujie Dun

Microbes are essentially yet convolutedly linked with human lives on the earth. They critically interfere in different physiological processes and thus influence overall health status. Studying microbial species is used to be constrained to…

Genomics · Quantitative Biology 2021-09-03 Chao Yang , Debajyoti Chowdhury , Zhenmiao Zhang , William K. Cheung , Aiping Lu , Zhao Xiang Bian , Lu Zhang

Deep neural networks (DNNs) are extensively employed in a wide range of application scenarios. Generally, training a commercially viable neural network requires significant amounts of data and computing resources, and it is easy for…

Cryptography and Security · Computer Science 2023-12-27 Huali Ren , Anli Yan , Xiaojun Ren , Pei-Gen Ye , Chong-zhi Gao , Zhili Zhou , Jin Li

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

Quantitative Methods · Quantitative Biology 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi

Understanding functional organization of genetic information is a major challenge in modern biology. Following the initial publication of the human genome sequence in 2001, advances in high-throughput measurement technologies and efficient…

Machine Learning · Statistics 2011-03-01 Leo Lahti

High-throughput sequencing (HTS) is revolutionizing biological research by enabling scientists to quickly and cheaply query variation at a genomic scale. Despite the increasing ease of obtaining such data, using these data effectively still…

Genomics · Quantitative Biology 2012-11-09 Sonal Singhal

Wireless fingerprinting refers to a device identification method leveraging hardware imperfections and wireless channel variations as signatures. Beyond physical layer characteristics, recent studies demonstrated that user behaviors could…

Information Theory · Computer Science 2023-08-30 Teng-Hui Huang , Thilini Dahanayaka , Kanchana Thilakarathna , Philip H. W. Leong , Hesham El Gamal

The de novo assembly of large, complex genomes is a significant challenge with currently available DNA sequencing technology. While many de novo assembly software packages are available, comparatively little attention has been paid to…

Genomics · Quantitative Biology 2013-07-31 Jared T. Simpson

Deep neural networks (DNNs) have shown incredible promise in learning fixed-length representations from fingerprints. Since the representation learning is often focused on capturing specific prior knowledge (e.g., minutiae), there is no…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Akash Godbole , Karthik Nandakumar , Anil K. Jain
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