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A novel data-driven constitutive modeling approach is proposed, which combines the physics-informed nature of modeling based on continuum thermodynamics with the benefits of machine learning. This approach is demonstrated on…

Computational Engineering, Finance, and Science · Computer Science 2023-04-28 Kshitiz Upadhyay , Jan N. Fuhg , Nikolaos Bouklas , K. T. Ramesh

For Minimally Invasive Surgical (MIS) robots, accurate haptic interaction force feedback is essential for ensuring the safety of interacting with soft tissue. However, most existing MIS robotic systems cannot facilitate direct measurement…

Robotics · Computer Science 2025-01-16 Jiayin Wang , Mingfeng Yao , Yanran Wei , Xiaoyu Guo , Ayong Zheng , Weidong Zhao

Mechanical stress within biological tissue can indicate an anomaly, or can be vital of its function, such as stresses in arteries. Measuring these stresses in tissue is challenging due to the complex, and often unknown, nature of the…

Soft Condensed Matter · Physics 2024-02-27 Harold Berjamin , Artur L. Gower

First principles microphysics models are essential to the design and analysis of high energy density physics experiments. Using experimental data to investigate the underlying physics is also essential, particularly when simulations and…

Plasma Physics · Physics 2013-06-04 Jim A Gaffney , Dan Clark , Vijay Sonnad , Stephen B Libby

Accurately measuring cell stiffness is challenging due to the invasiveness of traditional methods like atomic force microscopy (AFM) and optical stretching. We introduce a non-invasive off-axis system using holographic imaging and acoustic…

The development of traction-force microscopy, in the past two decades, has created the unprecedented opportunity of performing direct mechanical measurements on living cells as they adhere or crawl on uniform or micro-patterned substrates.…

Biological Physics · Physics 2019-10-25 Luca Giomi

The constitutive relation for an initially stressed reference is often determined by using the response of a virtual stress-free reference. However, identifying the constitutive relation of the original stress-free body can be challenging…

Materials Science · Physics 2025-03-13 Soumya Mukherjee

We study the effective forces acting between colloidal particles trapped at a fluid interface which itself is exposed to a pressure field. To this end we apply what we call the ``force approach'', which relies solely on the condition of…

Soft Condensed Matter · Physics 2008-03-31 Alvaro Dominguez , Martin Oettel , Siegfried Dietrich

Bioimpedance is an extensively studied non-invasive technique with diverse applications in biomedicine. This comprehensive review delves into the foundational concepts, technical intricacies, and practical implementations of bioimpedance.…

Medical Physics · Physics 2025-04-14 Manender Yadav , Shreyansh Shukla , Varsha Kiron , U. Deva Priyakumar , Maitreya Maity

The loading of a granular material induces anisotropies of the particle arrangement (fabric) and of the material's strength, incremental stiffness, and permeability. Thirteen measures of fabric anisotropy are developed, which are arranged…

Soft Condensed Matter · Physics 2018-12-21 Matthew R. Kuhn , WaiChing Sun , Qi Wang

Network data are increasingly collected along with other variables of interest. Our motivation is drawn from neurophysiology studies measuring brain connectivity networks for a sample of individuals along with their membership to a low or…

Methodology · Statistics 2018-09-11 Daniele Durante , David B. Dunson

Estimation of a hand grip force is essential for the understanding of force pattern during the execution of assembly or disassembly operations. Human demonstration of a correct way of doing an operation is a powerful source of information…

Robotics · Computer Science 2018-03-06 Andrey Sartison , Dima Mironov , Kamal Youcef-Toumi , Dzmitry Tsetserukou

This work demonstrates the benefits of using tool-tissue interaction forces in the design of autonomous systems in robot-assisted surgery (RAS). Autonomous systems in surgery must manipulate tissues of different stiffness levels and hence…

We address in this paper a new approach for fitting spatiotemporal models with application in disease mapping using the interaction types 1,2,3, and 4. When we account for the spatiotemporal interactions in disease-mapping models, inference…

Methodology · Statistics 2022-06-22 Esmail Abdul Fattah , Haavard Rue

Tissues are characterized by layers of functional units such as cells and extracellular matrix (ECM). Nevertheless, how dynamics at interlayer interfaces help transmit cellular forces in tissues remains overlooked. Here, we investigate a…

Biological Physics · Physics 2021-11-24 Yuting Lou , Takumi Kawaue , Ivan Yow , Yusuke Toyama , Jacques Prost , Tetsuya Hiraiwa

Background: Palpation is the most widely used approach to empirically assess the mechanical properties of superficial tissues. While elastography is used for volume measurements, it remains difficult to assess skin properties with…

The vertex model is widely used to describe the dynamics of epithelial tissues, because of its simplicity and versatility and the direct inclusion of biophysical parameters. Here, it is shown that quite generally, when cells modify their…

Soft Condensed Matter · Physics 2020-11-25 Fernanda Perez-Verdugo , Jean-Francois Joanny , Rodrigo Soto

A MEMS-based sensing device is used to measure the normal and tangential stress fields at the base of a rough elastomer film in contact with a smooth glass cylinder in steady sliding. This geometry allows for a direct comparison between the…

Soft Condensed Matter · Physics 2009-11-15 Julien Scheibert , Alexis Prevost , Georges Debrégeas , Eytan Katzav , Mohktar Adda-Bedia

This study aims to leverage the relationship between fluid dynamic loading and resulting structural deformation to infer the incident flow speed from measurements of time-dependent structure kinematics. Wind tunnel studies are performed on…

Fluid Dynamics · Physics 2021-03-19 Jennifer L. Cardona , Katherine L. Bouman , John O. Dabiri

Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions. The validity and scope of this…