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Several cellular activities, such as directed cell migration, are coordinated by an intricate network of biochemical reactions which lead to a polarised state of the cell, in which cellular symmetry is broken, causing the cell to have a…

Cell Behavior · Quantitative Biology 2018-09-13 Davide Cusseddu , Leah Edelstein-Keshet , John A. Mackenzie , Stéphanie Portet , Anotida Madzvamuse

Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such "bond-network" condensates comprised of two…

Soft Condensed Matter · Physics 2022-02-02 Pierre Ronceray , Yaojun Zhang , Xichong Liu , Ned S. Wingreen

Nucleation in systems with a metastable liquid-gas critical point is the prototypical example of a two-step nucleation process, in which the appearance of the critical nucleus is preceded by the formation of a liquid-like density…

Soft Condensed Matter · Physics 2023-04-07 Camilla Beneduce , Diogo E. P. Pinto , Petr Sulc , Francesco Sciortino , John Russo

Plasticity in amorphous solids is mediated by localized quadrupolar instabilities, but the mechanism by which an amorphous solid eventually fails or melts is debated. In this work we argue that these phenomena can be investigated in the…

Statistical Mechanics · Physics 2020-04-29 Eric De Giuli

Normal mode analysis offers an efficient way of modeling the conformational flexibility of protein structures. Simple models defined by contact topology, known as elastic network models, have been used to model a variety of systems, but the…

Biomolecules · Quantitative Biology 2007-05-23 Dmitry A. Kondrashov , Adam W. Van Wynsberghe , Ryan M. Bannen , Qiang Cui , George N. Phillips

In view of the notorious complexity of protein--protein interactions, simplified models of proteins treated as patchy particles offer a promising strategy to obtain insight into the mechanism of crystallization. Here we report…

Soft Condensed Matter · Physics 2019-10-16 Jens Glaser , Sharon C. Glotzer

The neutron and proton single-particle spectral functions in asymmetric nuclear matter fulfill energy weighted sum rules. The validity of these sum rules within the self-consistent Green's function approach is investigated. The various…

Nuclear Theory · Physics 2007-05-23 Arnau Rios , Artur Polls , Herbert Müther

Membrane bending is an extensively studied problem from both modeling and experimental perspectives because of the wide implications of curvature generation in cell biology. Many of the curvature generating aspects in membranes can be…

Soft Condensed Matter · Physics 2021-07-21 Arijit Mahapatra , David Saintillan , Padmini Rangamani

There are large number of proteins, the existence of which are known but not their crystal structure, because of difficulty in finding the exact condition for their crystallization. Heterogeneous nucleation on disordered porous substrates…

Biological Physics · Physics 2015-10-19 Anindita Sengupta Ghatak , Animangsu Ghatak

We demonstrate that tunable attractive (bonding) and repulsive (anti-bonding) forces can arise in highly asymmetric structures coupled to external radiation, a consequence of the bonding/anti-bonding level repulsion of guided-wave…

Channel proteins, that selectively conduct molecules across cell membranes, often exhibit an asymmetric structure. By means of a stochastic model, we argue that channel asymmetry in the presence of non-equilibrium fluctuations, fueled by…

Biological Physics · Physics 2007-05-23 Ioan Kosztin , Klaus Schulten

Precipitation of fine particles into the base material of a metal is a potent strengthening mechanism. This is numerically analyzed within a continuum framework based on a higher order strain gradient plasticity theory and by use of an…

Materials Science · Physics 2021-06-17 Mohammadali Asgharzadeh , Jonas Faleskog

Empty liquids represent a wide class of materials whose constituents arrange in a random network through reversible bonds. Many key insights on the physical properties of empty liquids have originated almost independently from the study of…

Soft Condensed Matter · Physics 2021-12-16 John Russo , Fabio Leoni , Fausto Martelli , Francesco Sciortino

So far the problem of interface behavior upon phase transition has not yet acquired a satisfactory mathematical formulation due to a variety of the physical phenomena involved. Analytical solutions exist only for elementary problems…

Statistical Mechanics · Physics 2011-08-12 Alex Guskov

Geophysical models of the atmosphere and ocean invariably involve parameterizations. These represent two distinct areas: Subgrid processes that the model cannot resolve, and diabatic sources in the equations, due to radiation for example.…

The role of discrete (or point-group) symmetries in alpha-cluster nuclei is discussed in the framework of the algebraic cluster model which describes the relative motion of the alpha-particles. Particular attention is paid to the discrete…

Nuclear Theory · Physics 2016-06-22 Roelof Bijker

In this paper, we investigate the asymptotic symmetry and monotonicity of positive solutions to a reaction-diffusion equation in the unit ball, utilizing techniques from elliptic geometry. Firstly, we discuss the properties of solutions in…

Analysis of PDEs · Mathematics 2024-09-10 Baiyu Liu , Wenlong Yang

The liquid-gas phase transition in hot asymmetric nuclear matter is investigated within relativistic mean-field model using the density dependence of nuclear symmetry energy constrained from the measured neutron skin thickness of finite…

Nuclear Theory · Physics 2014-11-20 Bharat K. Sharma , Subrata Pal

Motion of protein drops on crystallization media during routine handling is a major factor affecting the reproducibility of crystallization conditions. Drop stability can be enhanced by chemical patterning to more effectively pin the drop's…

Soft Condensed Matter · Physics 2007-05-23 Viatcheslav Berejnov , Robert E. Thorne

We present a novel method for the accurate numerical determination of the phase behavior of fluid mixtures having large particle size asymmetries. By incorporating the recently developed geometric cluster algorithm within a restricted Gibbs…

Soft Condensed Matter · Physics 2007-05-23 Jiwen Liu , Nigel B. Wilding , Erik Luijten