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Recent work has shown that the resistive force arising from viscous effects within the pore region could explain [Ghosal, S. Phys. Rev. E. vol. 71, 051904 (2006) and Phys. Rev. Lett. vol. 98, 238104 (2007)] observed translocation times in…

Biological Physics · Physics 2012-03-12 Sandip Ghosal

We report optical trapping and transport of nanoparticles in a moving interference pattern in hollow-core photonic crystal fiber at atmospheric pressure, when competition between trapping and drag forces causes the particle velocity to…

In this work we numerically calculate the electric current through three kinds of DNA sequences (telomeric, \lambda-DNA, and p53-DNA) described by different heuristic models. A bias voltage is applied between two zig-zag edged graphene…

Mesoscale and Nanoscale Physics · Physics 2012-10-02 Carlos J. Páez , Peter A. Schulz , Neil Wilson , Rudolf A. Römer

Intracellular positive ions neutralise negative charges on the phosphates of a DNA strand conferring greater strength on the hydrogen bonds that connect complementary strands into a double helix and so confer enhanced stability. Beyond a…

Soft Condensed Matter · Physics 2016-04-25 Arghya Maity , Amar Singh , Navin Singh

Recent experiments measuring the electrical conductivity of DNA molecules highlight the need for a theoretical model of ion transport along a charged surface. Here we present a simple theory based on the idea of unbinding of ion pairs. The…

Soft Condensed Matter · Physics 2009-10-23 Brian Skinner , M. S. Loth , B. I. Shklovskii

Ionic Coulomb blockade in nanopores is a phenomenon that shares some similarities but also differences with its electronic counterpart. Here, we investigate extensively this phenomenon using all-atom molecular dynamics of ionic transport…

Mesoscale and Nanoscale Physics · Physics 2017-12-27 Hiroya Tanaka , Hideo Iizuka , Yuriy V. Pershin , Massimiliano Di Ventra

Bacterial DNA gyrase introduces negative supercoils into chromosomal DNA and relaxes positive supercoils introduced by replication and transiently by transcription. Removal of these positive supercoils is essential for replication fork…

Proteins are the active working horses in our body. These biomolecules perform all vital cellular functions from DNA replication and general biosynthesis to metabolic signaling and environmental sensing. While static 3D structures are now…

Quantitative Methods · Quantitative Biology 2020-10-16 Sonja Schmid , Cees Dekker

Nanopore sensing is a key technology for single-molecule detection and analysis. Solid-state nanopores have emerged as a versatile platform, since their fabrication allows to engineer their properties by controlling size, shape, and…

The success of graphene for nanopore DNA sequencing has shown that it is possible to explore other potential single-atom and few-atom thick layers of elemental 2D materials beyond graphene (e.g., phosphorene and silicene). Using density…

Mesoscale and Nanoscale Physics · Physics 2021-12-15 Matthew B. Henry , Mukesh Tumbapo , Benjamin O. Tayo

Strong coupling between light and matter is the foundation of promising quantum photonic devices such as deterministic single photon sources, single atom lasers and photonic quantum gates, which consist of an atom and a photonic cavity.…

A class of nucleosome remodeling motors translocate nucleosomes, to which they are attached, toward the middle of DNA chain in the presence of ATP during in vitro experiments. Such a biological activity is likely based on a physical…

Biological Physics · Physics 2016-05-23 Kuni H. Iwasa , Ana Maria Florescu

We use computer simulations to study the kinetics and mechanism of proton passage through a narrow-pore carbon-nanotube membrane separating reservoirs of liquid water. Free energy and rate constant calculations show that protons move across…

Soft Condensed Matter · Physics 2009-11-11 Christoph Dellago , Gerhard Hummer

Single molecule microscopy has proven to be an effective tool to characterize the fluorophore-plasmonic structure interaction. However, as specific information is hidden in the emission, sophisticated evaluation is required. Here we…

Optics · Physics 2024-01-11 T. Novák , P. Bíró , Gy. Ferenc , D. Ungor , E. Czvik , Á. Deák , L. Janovák , M. Erdélyi

The transport of DNA polymers through nanoscale pores is central to many biological processes, from bacterial gene exchange to viral infection. In single-molecule nanopore sensing, the detection of nucleic acid and protein analytes relies…

Periodic arrays of micro- or nano-pillars constitute solid state matrices with excellent properties for DNA size separation. Nanofabrication technologies offer many solutions to tailor the geometry of obstacle arrays, yet most studies have…

Biological Physics · Physics 2014-09-02 Yannick Viero , Qihao He , Marc Fouet , Aurélien Bancaud

We demonstrate an optical method for detecting the mechanical oscillations of an atom with single-phonon sensitivity. The measurement signal results from the interference between the light scattered by a single trapped atomic ion and that…

Atomic Physics · Physics 2021-08-11 G. Cerchiari , G. Araneda , L. Podhora , L. Slodička , Y. Colombe , R. Blatt

Single-molecule based 3rd generation DNA sequencing technologies have been explored with tremendous effort, among which nanopore sequencing is considered as one of the most promising to achieve the goal of $1,000 genome project towards…

Genetic information is stored in a linear sequence of base-pairs; however, thermal fluctuations and complex DNA conformations such as folds and loops make it challenging to order genomic material for in vitro analysis. In this work, we…

The characterization of individual nanoparticles in a liquid constitutes a critical challenge for environmental, material, and biological sciences. To detect nanoparticles, electronic approaches are especially desirable owing to their…

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